Effect of age on the fractional anisotropy (FA) value of peripheral nerves and clinical significance of the age-corrected FA value for evaluating polyneuropathies

Tanitame, Keizo; Iwakado, Yoshiko; Akiyama, Yuji; Ueno, Hiroki; Ochi, Kazuhide; Otani, Keiko; Takasu, Miyuki; Date, Shuji; Awai, Kazuo

doi:10.1007/s00234-011-0981-9

Cited by 20 publications

(23 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As in previous reports, 16,20,33 we found that FA decreases moderately with age (Pearson correlation coefficient, −0.38; P = 0.01). T2-weighted normalized signal, ADC, and AD did not correlate with age (P > 0.05).…”

Section: Effect Of Agesupporting

confidence: 72%

Diffusion Tensor Imaging Adds Diagnostic Accuracy in Magnetic Resonance Neurography

Breckwoldt

Stock

Xia

et al. 2015

Investigative Radiology

View full text Add to dashboard Cite

show abstract

Section: Effect Of Agesupporting

confidence: 72%

Diffusion Tensor Imaging Adds Diagnostic Accuracy in Magnetic Resonance Neurography

Breckwoldt

Stock

Xia

et al. 2015

Investigative Radiology

View full text Add to dashboard Cite

show abstract

“…Interestingly, a similar relationship has been observed for diffusion metrics in nerve. 33 For MTR values of proximal nerve, additional data are needed to demonstrate whether such a relationship exists. Nevertheless, the effect of age (and BMI) on MTR was small in the current study; therefore, the observed differences are likely driven by pathologic rather than demographic factors.…”

Section: Resultsmentioning

confidence: 99%

Proximal nerve magnetization transfer MRI relates to disability in Charcot-Marie-Tooth diseases

et al. 2014

View full text Add to dashboard Cite

Objective: The objectives of this study were (1) to develop a novel magnetization transfer ratio (MTR) MRI assay of the proximal sciatic nerve (SN), which is inaccessible via current tools for assessing peripheral nerves, and (2) to evaluate the resulting MTR values as a potential biomarker of myelin content changes in patients with Charcot-Marie-Tooth (CMT) diseases.Methods: MTR was measured in the SN of patients with CMT type 1A (CMT1A, n 5 10), CMT type 2A (CMT2A, n 5 3), hereditary neuropathy with liability to pressure palsies (n 5 3), and healthy controls (n 5 21). Additional patients without a genetically confirmed subtype (n 5 4), but whose family histories and electrophysiologic tests were consistent with CMT, were also included. The relationship between MTR and clinical neuropathy scores was assessed, and the interscan and inter-rater reliability of MTR was estimated.Results: Mean volumetric MTR values were significantly decreased in the SN of patients with CMT1A (33.8 6 3.3 percent units) and CMT2A (31.5 6 1.9 percent units) relative to controls (37.2 6 2.3 percent units). A significant relationship between MTR and disability scores was also detected (p 5 0.01 for genetically confirmed patients only, p 5 0.04 for all patients). From interscan and inter-rater reliability analyses, proximal nerve MTR values were repeatable at the slicewise and mean volumetric levels. Charcot-Marie-Tooth (CMT) diseases are a group of inherited neuropathies that affect motor and sensory nerves. A majority of CMT phenotypes can be classified as primary demyelination/dysmyelinating (CMT1) or primary axonal (CMT2) neuropathies.1,2 CMT type 1A (CMT1A z 80% of CMT1 cases 3,4 ) arises from duplication of the peripheral myelin protein 22 (PMP22) gene 5,6 and results in dysmyelination and secondary axonal loss. 7 CMT type 2A (CMT2A z 35% of CMT2 cases 8 ) is caused by missense mutations in the gene that encodes for mitofusin 2 9 and leads to primary axonal degeneration. 8 Although the pathologic features of CMT1A/CMT2A are different, length-dependent axonal loss occurs in both and is predictive of outcomes.

show abstract

“…First, our case series involved only healthy volunteers, and their age group was relatively young. Although changes in the FA of the peripheral nerves caused by ageing have been reported, 21 these changes may not be very important because of the bilateral symmetry of the FA for the IAN. However, further studies are needed to confirm such changes in the IAN.…”

Section: Discussionmentioning

confidence: 99%

“…According to several previous studies Dentomaxillofac Radiol, 45, 20160200 birpublications.org/dmfr DTI of the IAN using 3T MRI that evaluated DTI of the peripheral nerves, the FA of an injured nerve became significantly lower than that of the normal nerve. [19][20][21] Furthermore, the use of DTI parameters on the contralateral side as an internal control was recommended for the evaluation of unilateral peripheral neuropathy. 22 These studies strongly indicate that differences in the condition of the IAN, such as normal and damaged regions, can be evaluated by comparisons of the values between the right and left IANs at the same positions.…”

Section: Discussionmentioning

confidence: 99%

Diffusion tensor imaging of the inferior alveolar nerve using 3T MRI: a study for quantitative evaluation and fibre tracking

Kotaki¹,

Sakamoto²,

Kretapirom³

et al. 2016

Dentomaxillofacial Radiology

View full text Add to dashboard Cite

Objectives: Diffusion tensor imaging (DTI) can provide structural information and objective values for nerves. The aims of this study were to perform quantitative evaluation and fibre tracking of the normal inferior alveolar nerve (IAN) using DTI on 3.0-T MRI. Methods: DTI was applied to 92 IANs of 46 healthy volunteers. Circular regions of interest (ROIs) were placed on three different positions at the mandibular foramen, second molar and mental foramen of each nerve on apparent diffusion coefficient (ADC) and fractional anisotropy (FA) maps, and the ADC and FA of each ROI were measured. Differences in the values arising from the nerve positions were evaluated. Furthermore, fibre tracking of the IANs was performed by tractography, and the quality of visualization was evaluated. Results: There were no significant differences in the ADC and FA between the right and left sides regardless of the anteroposterior positions. Regarding differences arising from the anteroposterior measurement positions, the ADC and FA showed no significant differences (p . 0.017), except for the ADCs between the positions at the mandibular foramen and mental foramen in the left side (p 5 0.0068). Overall, 70 (76%) of the 92 IANs could be visualized fully or partially by tractography. Conclusions: The ADC and FA of the IAN were successfully obtained from healthy volunteers using DTI and were confirmed to be symmetrical regardless of the measurement positions. DTI is a feasible technique for the quantitative evaluation and visualization of the IAN.

show abstract

Effect of age on the fractional anisotropy (FA) value of peripheral nerves and clinical significance of the age-corrected FA value for evaluating polyneuropathies

Abstract: The age-corrected FA value of the peripheral nerves helps to differentiate between age-related peripheral nerve degeneration and polyneuropathies.

Cited by 20 publications

References 39 publications

Diffusion Tensor Imaging Adds Diagnostic Accuracy in Magnetic Resonance Neurography

Diffusion Tensor Imaging Adds Diagnostic Accuracy in Magnetic Resonance Neurography

Proximal nerve magnetization transfer MRI relates to disability in Charcot-Marie-Tooth diseases

Diffusion tensor imaging of the inferior alveolar nerve using 3T MRI: a study for quantitative evaluation and fibre tracking

Contact Info

Product

Resources

About