Effect of ageing on beta-cell mass and function in rats malnourished during the perinatal period

Garofano, A.; Czernichow, P; Bréant, Bernadette

doi:10.1007/s001250051219

Cited by 165 publications

(108 citation statements)

References 28 publications

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“…The tendency for decreased total islet volume and the decreased numbers of large islets in the SFA group is consistent with earlier studies with low protein diets [8,28,29,30]. They showed that impaired islet development at weaning is not fully compensated by islet growth and neogenesis later in life.…”

Section: Discussionsupporting

confidence: 91%

Dietary fatty acid composition during pregnancy and lactation in the rat programs growth and glucose metabolism in the offspring

et al. 2002

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Aims/hypothesis. We investigated of the effects of fatty acid composition of the maternal diet on fetal and postnatal growth, morphology of the pancreas and glucose metabolism and muscle hexosamine concentrations in the adult offspring of rats. Methods. High-fat diets enriched with either saturated or unsaturated fatty acids were fed to female adult rats 2 weeks before mating until the end of the weaning period. After weaning, the offspring was maintained on a diet with a balanced fatty acid content. At 3 months of age, pancreatic Langerhans islet size and number were assessed by morphometric analysis and oral glucose tolerance tests (OGTT) were carried out. Results. The unsaturated fatty acid diet showed lower birth weight and reduced postnatal weight gain. Furthermore, this group showed increased pancreatic islet numbers without affected glucose tolerance at the age of 12 weeks. The offspring of the saturated fatty acid diet group showed a reduced number of large pancreatic islets. Moreover, a faster and higher insulin response was observed after an oral glucose load in these animals. Muscle hexosamine concentrations were not different between groups. Conclusion/interpretation. Maternal diets enriched with either saturated fatty acids or unsaturated fatty acids had opposite effects on pancreatic islet development in rat offspring, with consequences for the insulin response at 12 weeks of age. Therefore, maternal dietary fatty acid composition plays a role in programming growth, pancreatic development and glucose metabolism in the offspring. [Diabetologia (2002[Diabetologia ( ) 45:1397[Diabetologia ( -1403

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Section: Discussionsupporting

confidence: 91%

Dietary fatty acid composition during pregnancy and lactation in the rat programs growth and glucose metabolism in the offspring

et al. 2002

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“…La restriction alimentaire globale : un rôle important pour les glucocorticoïdes et le stress La restriction de 50 % des apports nutritionnels maternels chez le rat, durant le dernier tiers de la gestation, provoque chez les foetus un retard de croissance irré-versible et une diminution de la masse de cellules bêta pancréatiques, qui persiste à l'âge adulte et conduit finalement à une intolérance au glucose [27]. Les états de dénutrition entraînent une activation de l'axe corticotrope et une sécrétion accrue de glucocorticoïdes (hypercorticisme) [28].…”

Section: La Preuve Expérimentale Par Les Modèles Animauxunclassified

Le concept des origines développementales de la santé

Munier¹,

Delpierre²,

Bréant³

2016

Med Sci (Paris)

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“…By 6 months of age it shows a marked reduction in beta cell mass and significantly raised glucose levels (31). Maternal calorie restriction in the rat to 50% ad libitum during pregnancy leads to low birth weight, beta cell dysfunction and to an age dependent loss of glucose tolerance (32). Severe calorie restriction in the pregnant rat to 30% ad libitum has been shown to lead to severe growth retardation of the fetus, along with Excessive dexamethasone exposure in rodents in utero also leads to low birth weight and permanent hypertension and hyperglycaemia in adult offspring (reviewed by Nyirenda and Seckl) (54), as well as having a negative effect on fetal beta cell development (55).…”

Section: Evidence From Animal Modelsmentioning

confidence: 99%

Fetal programming of glucose–insulin metabolism

Jones

Ozanne

2009

Molecular and Cellular Endocrinology

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Epidemiological studies have shown a link between poor fetal growth and increased risk of developing type 2 diabetes. These observations are highly reproducible in many populations worldwide although the mechanisms behind them remain elusive.The 'Thrifty Phenotype Hypothesis' was proposed to explain the underlying causes of these relationships. Animal models of poor intrauterine nutrition have been utilised to help to define the causal factors and identify the molecular mechanisms. Programmed changes in beta cell function and insulin action have been a common feature of animal models of poor intrauterine nutrition. Fundamental underlying mechanisms are starting to emerge, including changes in the epigenotype and mitochondrial function.

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Effect of ageing on beta-cell mass and function in rats malnourished during the perinatal period

Abstract: In conclusion, perinatal malnutrition profoundly impairs the programming of beta-cell development. In animals with decreased beta-cell mass the additional demand placed by ageing on the beta cells entails glucose intolerance since beta-cell mass does not expand and apoptosis is increased.

Cited by 165 publications

References 28 publications

Dietary fatty acid composition during pregnancy and lactation in the rat programs growth and glucose metabolism in the offspring

Dietary fatty acid composition during pregnancy and lactation in the rat programs growth and glucose metabolism in the offspring

Le concept des origines développementales de la santé

Fetal programming of glucose–insulin metabolism

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