Effect of aging on 24-hour pattern of stress hormones and leptin in rats

Cano, Pilar; Cardinali, Daniel P.; Spinedi, Eduardo; Esquifino, Ana I.

doi:10.1016/j.lfs.2008.06.001

Cited by 9 publications

(6 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This observation is consistent with previous studies (e.g., Cano et al 2008;Cizza et al 1994), although inconsistent with others (e.g., Bizon et al 2001;Montaron et al 2006;Workel et al 2001). Among factors that could account for the discrepant findings, the time of the light-dark cycle at which the samples were collected may be of major relevance (Cano et al 2008). Confirming previous reports in adult rats (e.g., Bakos et al 2009;Leal-Galicia et al 2007;Schrijver et al 2002; but see Moncek et al 2004), we observed that enrichment did not influence the basal corticosterone level, whatever the age.…”

Section: Basal Corticosterone Levelssupporting

confidence: 94%

Section: Basal Corticosterone Levelssupporting

confidence: 84%

See 1 more Smart Citation

Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan

Harati

Barbelivien

Herbeaux

et al. 2012

AGE

View full text Add to dashboard Cite

We assessed lifelong environmental enrichment effects on possible age-related modifications in emotional behaviors, spatial memory acquisition, retrieval of recent and remote spatial memory, and cholinergic forebrain systems. At the age of 1 month, Long-Evans female rats were placed in standard or enriched rearing conditions and tested after 3 (young), 12 (middle-aged), or 24 (aged)months. Environmental enrichment decreased the reactivity to stressful situations regardless of age. In the water maze test, it delayed the onset of learning deficits and prevented age-dependent spatial learning and recent memory retrieval alterations. Remote memory retrieval, which was altered independently of age under standard rearing conditions, was rescued by enrichment in young and middle-aged, but unfortunately not aged rats. A protected basal forebrain cholinergic system, which could well be one out of several neuronal manifestations of lifelong environmental enrichment, might have contributed to the behavioral benefits of this enrichment.

show abstract

Section: Basal Corticosterone Levelssupporting

confidence: 94%

Section: Basal Corticosterone Levelssupporting

confidence: 84%

Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan

Harati

Barbelivien

Herbeaux

et al. 2012

AGE

View full text Add to dashboard Cite

show abstract

“…This effect can be in part attributed to an age-related decline in glucocorticoid function. 48,49 In a previous study investigating food-induced peripheral clock entrainment, phase changes were accelerated in adrenalectomized and glucocorticoid receptor knockout mice. 55 Age-related alterations in glucocorticoid signaling were also observed in the present study.…”

Section: Discussionmentioning

confidence: 98%

“…Previous studies have identified lower concentrations of baseline and stress-evoked serum corticosterone in aged mice. 48,49 Alternatively, oxidative stress has been purported to have a role in the stress-induced entrainment of peripheral clocks in vitro and in vivo . 50,51 Aging is associated with the accumulation of reactive oxygen species and the impairment of anti-oxidant systems.…”

Section: Discussionmentioning

confidence: 99%

Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation

et al. 2017

View full text Add to dashboard Cite

The ability of the circadian clock to adapt to environmental changes is critical for maintaining homeostasis, preventing disease, and limiting the detrimental effects of aging. To date, little is known about age-related changes in the entrainment of peripheral clocks to external cues. We therefore evaluated the ability of the peripheral clocks of the kidney, liver, and submandibular gland to be entrained by external stimuli including light, food, stress, and exercise in young versus aged mice using in vivo bioluminescence monitoring. Despite a decline in locomotor activity, peripheral clocks in aged mice exhibited normal oscillation amplitudes under light–dark, constant darkness, and simulated jet lag conditions, with some abnormal phase alterations. However, age-related impairments were observed in peripheral clock entrainment to stress and exercise stimuli. Conversely, age-related enhancements were observed in peripheral clock entrainment to food stimuli and in the display of food anticipatory behaviors. Finally, we evaluated the hypothesis that deficits in sympathetic input from the central clock located in the suprachiasmatic nucleus of the hypothalamus were in part responsible for age-related differences in the entrainment. Aged animals showed an attenuated entrainment response to noradrenergic stimulation as well as decreased adrenergic receptor mRNA expression in target peripheral organs. Taken together, the present findings indicate that age-related circadian disorganization in entrainment to light, stress, and exercise is due to sympathetic dysfunctions in peripheral organs, while meal timing produces effective entrainment of aged peripheral circadian clocks.

show abstract

“…In addition to noradrenaline, in the rat, glucocorticoids affect microglial morphology and reduce microglial activation [78] and phagocytosis [79]. Moreover, continuous low levels with no time-of-day variations in adrenal corticosterone were observed in aged rat [80]. As mentioned above, the rhythmicity of microglial cells depends on the patterns of noradrenaline, as well as corticosterone, and these patterns are compromised in the aged brain.…”

Section: Diurnal Rhythmicity Of Senescent Microgliamentioning

confidence: 90%

Microglia and the Aging Brain: Are Geriatric Microglia Linked to Poor Sleep Quality?

Choudhury

Miyanishi

Tamano

et al. 2021

IJMS

View full text Add to dashboard Cite

Poor sleep quality and disrupted circadian behavior are a normal part of aging and include excessive daytime sleepiness, increased sleep fragmentation, and decreased total sleep time and sleep quality. Although the neuronal decline underlying the cellular mechanism of poor sleep has been extensively investigated, brain function is not fully dependent on neurons. A recent antemortem autographic study and postmortem RNA sequencing and immunohistochemical studies on aged human brain have investigated the relationship between sleep fragmentation and activation of the innate immune cells of the brain, microglia. In the process of aging, there are marked reductions in the number of brain microglial cells, and the depletion of microglial cells disrupts circadian rhythmicity of brain tissue. We also showed, in a previous study, that pharmacological suppression of microglial function induced sleep abnormalities. However, the mechanism underlying the contribution of microglial cells to sleep homeostasis is only beginning to be understood. This review revisits the impact of aging on the microglial population and activation, as well as microglial contribution to sleep maintenance and response to sleep loss. Most importantly, this review will answer questions such as whether there is any link between senescent microglia and age-related poor quality sleep and how this exacerbates neurodegenerative disease.

show abstract

Effect of aging on 24-hour pattern of stress hormones and leptin in rats

Cited by 9 publications

References 57 publications

Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan

Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan

Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation

Microglia and the Aging Brain: Are Geriatric Microglia Linked to Poor Sleep Quality?

Contact Info

Product

Resources

About