Effect of aging on audiovisual integration: Comparison of high- and low-intensity conditions in a speech discrimination task

Yang, Weiping; Yao, Huan; Yang, Xiangfu; Li, Zimo; Li, Shengnan; Chen, Jianxin; Ren, Yanna; Yang, Jiajia; Wu, Jinglong; Zhang, Zhilin

doi:10.3389/fnagi.2022.1010060

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…1 Aging is the leading risk factor for the development of neurodegenerative diseases, including Alzheimer's disease (AD), 2 and age-related cognitive decline affects more than 50% of people over the age of 60. 3 Neural loss and decreased synaptic function are the main causes of cognitive impairment. 4 Generally, the decline in cognitive ability and the onset of neuroinflammation begins in midadulthood and accelerates in old age.…”

Section: Introductionmentioning

confidence: 99%

“…Brain aging is accompanied by gradual changes in the brain, such as decreased neurophysiological functions, impaired neuroplasticity, dysregulated neuronal Ca 2+ homeostasis, neuroinflammation, and oxidative stress . Aging is the leading risk factor for the development of neurodegenerative diseases, including Alzheimer’s disease (AD), and age-related cognitive decline affects more than 50% of people over the age of 60 . Neural loss and decreased synaptic function are the main causes of cognitive impairment .…”

Section: Introductionmentioning

confidence: 99%

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Hydrolyzed Chicken Meat Extract and Its Bioactive Cyclopeptides Protect Neural Function by Attenuating Inflammation and Apoptosis via PI3K/AKT and AMPK Pathways

Ni,

Wang,

Zhuge

et al. 2024

J. Agric. Food Chem.

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Cognitive decline is inevitable with age, and due to the lack of well-established pharmacotherapies for neurodegenerative disorders, dietary supplements have become important alternatives to ameliorate brain deterioration. Hydrolyzed chicken meat extract (HCE) and its bioactive components were previously found to improve neuroinflammation and cognitive decline by regulating microglia polarization. However, the effects and mechanisms of these bioactives on neurons remain unclear.Here, the most potent bioactive component on neural function in HCE was screened out, and the detailed mechanism was clarified through in vivo and in vitro experiments. We found that HCE, cyclo(Val-Pro), cyclo(Phe-Phe), cyclo(His-Pro), cyclo(Leu-Lys), and arginine exerted stronger anti-inflammatory and antioxidant effects among the 12 bioactives in amyloid β (Aβ)-treated HT-22 cells. Further transcriptome sequencing and polymerase chain reaction (PCR) array analysis showed that these bioactives participated in different signaling pathways, and cyclo(Val-Pro) was identified as the most potent cyclic dipeptide. In addition, the antiapoptotic and neuroprotective effect of cyclo(Val-Pro) was partly regulated by the activation of PI3K/AKT and AMPK pathways, and the inhibition of these pathways abolished the effect of cyclo(Val-Pro). Moreover, cyclo(Val-Pro) enhanced cognitive function and neurogenesis and alleviated neuroinflammation and oxidative stress in middle-aged mice, with an effect similar to HCE. Hippocampal transcriptome analysis further revealed that HCE and cyclo(Val-Pro) significantly enriched the neuroactive ligand− receptor interaction pathway, verified by enhanced neurotransmitter levels and upregulated neurotransmitter receptor-related gene expression. Therefore, the mechanism of cyclo(Val-Pro) on neural function might be associated with PI3K/AKT and AMPK pathway-mediated antiapoptotic effect and neurogenesis and the activation of the neurotransmitter-receptor pathway.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hydrolyzed Chicken Meat Extract and Its Bioactive Cyclopeptides Protect Neural Function by Attenuating Inflammation and Apoptosis via PI3K/AKT and AMPK Pathways

Ni,

Wang,

Zhuge

et al. 2024

J. Agric. Food Chem.

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Development of a BCI system for Enhancing Human-Robot Interaction in Cognitive Stimulation Therapy

Minhaj,

Hung,

Man

2023

2023 8th International Conference on Instrumentation, Control, and Automation (ICA)

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Age-related Electrophysical Correlates of Cross-modal Attention Switching

Huang,

Schils,

Koch

et al. 2025

Journal of Cognitive Neuroscience

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The human experience demands seamless attentional switches between sensory modalities. Aging raises questions about how declines in auditory and visual processing affect cross-modal attention switching. This study used a cued cross-modal attention-switching paradigm where visual and auditory stimuli were simultaneously presented on either spatially congruent or incongruent sides. A modality cue indicated the target modality, requiring a spatially left versus right key-press response. EEG recordings were collected during task performance. We investigated whether the mixing costs (decreased performance for repetition trials in a mixed task compared with a single task) and switch costs (decreased performance for a switch of target modality compared with a repetition) in cross-modal attention-switching paradigms would exhibit similarities in terms of behavioral performance and the ERP components to those observed in the traditional unimodal attention-switching paradigms. Specifically, we focused on the ERP components: cue-locked P3 (mixing/switch-related increased positivity), target-locked P3 (mixing/switch-related decreased positivity), and target-locked lateralized readiness potential (mixing/switch-related longer latency). In addition, we assessed how aging impacts cross-modal attention-switching performance. Results revealed that older adults exhibited more pronounced mixing and switch costs than younger adults, especially when visual and auditory stimuli were presented on incongruent sides. ERP findings showed increased cue-locked P3 amplitude, prolonged cue-locked P3 latency, decreased target-locked P3 amplitude, prolonged target-locked P3 latency in association with switch costs, and prolonged onset latency of the target-locked lateralized readiness potential in association with the mixing costs. Age-related effects were significant only for cue-locked P3 amplitude, cue-locked P3 latency (switch-related), and target-locked P3 latency (switch-related). These findings suggest that the larger mixing costs and switch costs in older adults were because of the inefficient use of modality cues to update a representation of the relevant task sets and required more processing time for evaluating and categorizing the target.

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Effect of aging on audiovisual integration: Comparison of high- and low-intensity conditions in a speech discrimination task

Cited by 3 publications

References 52 publications

Hydrolyzed Chicken Meat Extract and Its Bioactive Cyclopeptides Protect Neural Function by Attenuating Inflammation and Apoptosis via PI3K/AKT and AMPK Pathways

Hydrolyzed Chicken Meat Extract and Its Bioactive Cyclopeptides Protect Neural Function by Attenuating Inflammation and Apoptosis via PI3K/AKT and AMPK Pathways

Development of a BCI system for Enhancing Human-Robot Interaction in Cognitive Stimulation Therapy

Age-related Electrophysical Correlates of Cross-modal Attention Switching

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