Effect of Aging on Experimental Autoimmune Prostatitis: Differential Kinetics of Development

Morón, Gabriel; Maletto, Belkys A.; Rópolo, Andrea S.; Pistoresi-Palencia, María C.

doi:10.1006/clin.1998.4534

“…87 Thus, this model is consistent with a self-limiting mild to moderate prostate inflammation induced by both humoral and cell-mediated mechanisms. 88 It has been speculated that inflammatory damage induced in this model might be the result of generation of autoreactive cytotoxic cells, increased levels of radical oxidative species from prostatic infiltrating macrophages, and upregulated mast cell degranulation. [89][90][91] These studies do not identify the specific prostatic proteins that are the targets on an immune response.…”

Section: Immune-induced Prostatitis Modelsmentioning

confidence: 94%

Experimental rodent models of prostatitis: limitations and potential

Vykhovanets

¹

,

Resnick

²

,

MacLennan

³

et al. 2007

Prostate Cancer Prostatic Dis

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Prostatitis is a polyetiological inflammation of the prostate gland in men characterized by pelvic pain, irritative voiding symptoms, and sexual dysfunction. Histologically prostatitis is characterized by poly-and mononuclear cell infiltrates (neutrophils, lymphocytes, macrophages and plasma cells) in the stromal connective tissue around the acini or ducts. Prostatitis is an important worldwide health problem in men. The pathogenesis and diagnostic criteria for the condition are obscure, with the result that the development of management programs for this condition has been hindered. Animal model(s) might be useful in elucidating mechanisms involved in the molecular pathogenesis of chronic nonbacterial prostatitis and chronic pelvic pain syndrome. Given that prostatitis might have a multifactorial etiology, several animal models with unique features may prove helpful. This review examines a number of experimental rodent models of prostatitis and evaluates their advantages and limitations.

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“…Despite the observed unaltered MBP‐specific T‐cell activation, the anti‐MBP IgG antibody levels were significantly decreased in middle‐aged compared with young animals. We have previously observed that the levels of total IgG and IgM against specific antigens in Wistar rats with autoimmune prostatitis were diminished in 12‐month‐old animals compared with 3‐month‐old animals, but normal 12‐month‐old rats showed higher levels of some natural antibodies compared to young rats 26 . The diminished disease‐specific humoral response observed in aged rats could probably reflect impaired communication between T and B cells, an intrinsic inability of B cells to respond to Th cells, or an alteration in the antibodies’ affinity 26 .…”

Section: Discussionmentioning

confidence: 94%

Age‐related changes in the development of experimental autoimmune encephalomyelitis

Ditamo¹,

Degano²,

Macció³

et al. 2004

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A prominent feature of multiple sclerosis is its high incidence of onset in the third decade of life and its relatively rare onset in persons older than 50 years. In order to study age-related restriction of clinical expression, a comparative biochemical, immunological and histological study was undertaken during development of experimental autoimmune encephalomyelitis (EAE) in young (7 weeks) and middle-aged (15 months) Wistar rats. Young rats showed characteristic clinical signs 12-16 days postinduction, and then they spontaneously recuperated. In middle-aged rats, the incidence of clinical signs was significantly reduced, with a later onset of the disease. Similar biochemical and histological alterations were detected in both age groups, but they were present in a later stage in middle-aged animals. However, cellular and humoral immune responses to myelin basic protein (MBP) were observed 15 days postinduction in all EAE animals. The study of anti-MBP IgG isotype pattern in 7-week-old animals indicated a predominant Th1-type immune response during the acute stage of EAE, with antibodies predominantly recognizing the MBP 96-128 peptide. In contrast, 15-month-old animals showed a less prominent Th1 response, without any epitope dominance. The changes in immune function found in middle-aged animals may account for the different susceptibility and expression of EAE, and may also be relevant to the different clinical expression observed in multiple sclerosis with maturation.

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“…We have previously observed that the levels of total IgG and IgM against specific antigens in Wistar rats with autoimmune prostatitis were diminished in 12-month-old animals compared with 3-month-old animals, but normal 12-month-old rats showed higher levels of some natural antibodies compared to young rats. 26 The diminished disease-specific humoral response observed in aged rats could probably reflect impaired communication between T and B cells, an intrinsic inability of B cells to respond to Th cells, or an alteration in the antibodies' affinity. 26 It is well known that a Th1-like immune response, characterized by secretion of proinflammatory cytokines, is responsible for cell-mediated immune reactions.…”

Section: Discussionmentioning

confidence: 99%

“…26 The diminished disease-specific humoral response observed in aged rats could probably reflect impaired communication between T and B cells, an intrinsic inability of B cells to respond to Th cells, or an alteration in the antibodies' affinity. 26 It is well known that a Th1-like immune response, characterized by secretion of proinflammatory cytokines, is responsible for cell-mediated immune reactions. 27,28 Several authors have demonstrated that Th1 cytokines are augmented during EAE development, 8 and a shift to a Th2 response has been associated with EAE spontaneous remission and recovery from other T-cell mediated autoimmune disorders.…”

Section: Discussionmentioning

confidence: 99%

“…29,30 The IgG1 isotype is associated with a Th2-like response, [31][32][33] and a Th1-like immune response is associated predominantly with the switching of secretion of immunoglobulins towards IgG2b in rats, while IgG2a is the Th1-dependent isotype in mice. 20,26,31,34 In EAE, an increase in serum IgG2b antibodies against myelin protein was also closely linked to the severity of clinical symptoms. 35 In our work, anti-MBP IgG isotype analysis showed significant lower IgG2b anti-MBP antibody titres during the acute period of the disease in middle-aged animals compared with young animals, indicating a possible diminished Th1-type response.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Age-related changes in the development of experimental autoimmune encephalomyelitis

Ditamo¹,

Degano²,

Macció³

et al. 2005

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A prominent feature of multiple sclerosis is its high incidence of onset in the third decade of life and its relatively rare onset in persons older than 50 years. In order to study age-related restriction of clinical expression, a comparative biochemical, immunological and histological study was undertaken during development of experimental autoimmune encephalomyelitis (EAE) in young (7 weeks) and middle-aged (15 months) Wistar rats. Young rats showed characteristic clinical signs 12-16 days postinduction, and then they spontaneously recuperated. In middle-aged rats, the incidence of clinical signs was significantly reduced, with a later onset of the disease. Similar biochemical and histological alterations were detected in both age groups, but they were present in a later stage in middle-aged animals. However, cellular and humoral immune responses to myelin basic protein (MBP) were observed 15 days postinduction in all EAE animals. The study of anti-MBP IgG isotype pattern in 7-week-old animals indicated a predominant Th1-type immune response during the acute stage of EAE, with antibodies predominantly recognizing the MBP 96-128 peptide. In contrast, 15-month-old animals showed a less prominent Th1 response, without any epitope dominance. The changes in immune function found in middle-aged animals may account for the different susceptibility and expression of EAE, and may also be relevant to the different clinical expression observed in multiple sclerosis with maturation.

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Effect of Aging on Experimental Autoimmune Prostatitis: Differential Kinetics of Development

Cited by 9 publications

References 17 publications

Experimental rodent models of prostatitis: limitations and potential

Experimental rodent models of prostatitis: limitations and potential

Age‐related changes in the development of experimental autoimmune encephalomyelitis

Age-related changes in the development of experimental autoimmune encephalomyelitis

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