“…For bone remodeling cycle activity ALP, OC, OPN, OPG and PTH were investigated in systemic bone changes Aging is associated with a decrease in mental and physical health and an increase in the risk of chronic diseases, such as atherosclerosis, cancer, diabetes and periodontitis. 3,4 It also affect the human immune response, particulary the T-lymphocyte system regarding to diminished count of T-cells in blood cells. 3,4 It has been suggested that abnormal higher interleukin-6 levels may be related to the pathogenesis of periodontal diseases in the elderly.…”