Effect of aging on plasma 1,5-anhydroglucitol levels in humans and rats

Funasako, Masato; Taniji, Masahiro; Fujimoto, Kazumi; Ohata, Masahiro; Higashimoto, Yuji; Uetani, Kosaku; Suruda, Tadatoshi; Nakai, S.; Fujimoto, Hisashi; Y, Sakagami

doi:10.1016/0168-8227(94)90159-7

Cited by 4 publications

(5 citation statements)

References 24 publications

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“…The results of study 1 suggest that the eff ects of aging on 1,5-AG levels in persons with near-normoglycemia are similar to those in persons with NGT. Most studies, including the present study, have found that serum 1,5-AG levels tend to be higher in males than in females ( Yamanouchi et al, 1988 ;Funasako et al, 1994 ). The mechanism of the eff ects of sex and age on serum 1,5-AG levels in the present study remains unclear.…”

contrasting

confidence: 44%

“…Although decreased serum 1,5-AG levels are observed in patients with renal failure ( Servo et al, 1977 ;Emoto et al, 1992 ), 1,5-AG excretion is not aff ected by mild renal dysfunction ( Yamanouchi et al, 1988 ). Therefore, the lower 1,5-AG levels observed in elderly subjects cannot be explained simply by decreased renal function ( Funasako et al, 1994 ).…”

mentioning

confidence: 93%

“…The relationship between age and 1,5-AG levels was also shown in a subanalysis focusing on the comparison of 2 groups classifi ed by 1,5-AG level. ( Funasako et al, 1994 ). Our present study has obtained similar results.…”

mentioning

confidence: 99%

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Effects of Sex and Age on Serum 1,5-anhydroglucitol in Nondiabetic Subjects

Ouchi

Oba

Yamashita

et al. 2012

Exp Clin Endocrinol Diabetes

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The aim of this study was to demonstrate the effects of sex and age on serum levels of 1,5-AG in nondiabetic subjects.A total of 1 134 nondiabetic subjects aged 16-96 years with HbA1c less than 6.8% were recruited and divided into 4 HbA1c groups (Q1: HbA1c≤5.3; Q2: 5.4-5.8; Q3: 5.9-6.3; and Q4: 6.4-6.8 [%]). 38 elderly subjects (65 years or older) in the Q3 and Q4 groups (13 men and 25 women) underwent a 75-g oral glucose tolerance test (OGTT).The Q4 group had significantly lower 1,5-AG levels than did the Q1 group among nonelderly males, nonelderly females, and elderly men. In elderly women, 1,5-AG levels did not differ among the 4 HbA1c groups. In both nonelderly and elderly subjects, the 1,5-AG level of the Q1 group was significantly higher in males than in females. Stepwise multivariate regression analysis showed that age was significantly associated with 1,5-AG level in both sexes. HbA1c was significantly associated with the 1,5-AG level in males, while there was no significant association between HbA1c and the 1,5-AG level in females. In the elderly OGTT group, although the glucose levels of both sexes during OGTT were identical, the mean urinary glucose levels and the percentages of subjects with glucosuria were significantly higher in elderly men than in elderly women.Serum 1,5-AG levels were significantly associated with age and sex. The sensitivity of the 1,5-AG level for identifying postprandial hyperglycemia in elderly women with near-normoglycemia is less reliable because they have a higher renal threshold for glucose.

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contrasting

confidence: 44%

mentioning

confidence: 93%

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Effects of Sex and Age on Serum 1,5-anhydroglucitol in Nondiabetic Subjects

Ouchi

Oba

Yamashita

et al. 2012

Exp Clin Endocrinol Diabetes

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“…A single in vitro report demonstrated that 1,5-AG induced insulin release in insulinoma cell lines [31]. On the other hand, previous studies, including ours, have demonstrated that serum 1,5-AG tends to decrease with age in rats [7] and humans [22]. More recently, research using high-resolution liquid chromatography-mass spectrometry demonstrated that 1,5-AG showed strikingly lower levels in healthy elderly subjects compared with healthy youths [2].…”

Section: Introductionmentioning

confidence: 52%

Development of an organ bath technique for isolated rat pancreas preparations to assess the effect of 1,5-AG on insulin secretion

et al. 2020

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To investigate substances related to insulin secretion, we reported a convenient experimental method to reproduce insulin secretion from isolated rat pancreas preparations using an organ bath. While the method has experimental utility for investigating insulin secretion, optimization of the experimental design is still needed. The level of insulin outflow in the control decreased over time in our previous study. Decreasing serum 1,5-anhydroglucitol (1,5-AG) levels is also known to be shown in patients with worsening glycemic control. There is one in vitro report demonstrated that 1,5-AG induced insulin release. It appears that discussion needs to be deepened further on it. In this study, we investigated the effect of 1,5-AG on insulin secretion through to optimize the condition of endocrine function using the ex vivo organ bath technique. The level of insulin outflow in the control and 1,5-AG groups decreased over time in the organ bath experiment. To analyze the effect of trypsin on reduced insulin secretion, pancreas preparation was treated with soybean trypsin inhibitor (TI). Insulin outflow levels of the TI group were significantly higher than the control group. An enzyme indicator of tissue damage tended to be lower in the TI group. There was no significant enhancement of insulin secretion by 1,5-AG. The present study demonstrated the utility of TI application for the organ bath technique. This finding supported the development of an organ bath technique for the assessment of the effects of novel therapeutics on insulin secretion.

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“…1,5‐Anhydroglucitol is a glycemic marker which is competitive to glucose for reabsorption, and its level of older human is lower than younger individuals (Dungan, 2008). We assumed that the over‐activation of LCT increased the expression of 1,5‐anhydroglucitol by glucose metabolic disorders, leading to bad glucometabolic control and finally promoting aging (Chaleckis et al., 2016; Funasako et al., 1994; Garvey et al., 2014).…”

Section: Discussionmentioning

confidence: 99%

Identification of prospective aging drug targets via Mendelian randomization analysis

Mao,

Li,

Xiao

2024

Aging Cell

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Aging represents a multifaceted process culminating in the deterioration of biological functions. Despite the introduction of numerous anti‐aging strategies, their therapeutic outcomes have often been less than optimal. Consequently, discovering new targets to mitigate aging effects is of critical importance. We applied Mendelian randomization (MR) to identify potential pharmacological targets against aging, drawing upon summary statistics from both the Decode and FinnGen cohorts, with further validation in an additional cohort. To address potential reverse causality, bidirectional MR analysis with Steiger filtering was utilized. Additionally, Bayesian co‐localization and phenotype scanning were implemented to investigate previous associations between genetic variants and traits. Summary‐data‐based Mendelian randomization (SMR) analysis was conducted to assess the impact of genetic variants on aging via their effects on protein expression. Additionally, mediation analysis was orchestrated to uncover potential intermediaries in these associations. Finally, we probed the systemic implications of drug‐target protein expression across diverse indications by MR‐PheWas analysis. Utilizing a Bonferroni‐corrected threshold, our MR examination identified 10 protein‐aging associations. Within this cohort of proteins, MST1, LCT, GMPR2, PSMB4, ECM1, EFEMP1, and ISLR2 appear to exacerbate aging risks, while MAX, B3GNT8, and USP8 may exert protective influences. None of these proteins displayed reverse causality except EFEMP1. Bayesian co‐localization inferred shared variants between aging and proteins such as B3GNT8 (rs11670143), ECM1 (rs61819393), and others listed. Mediator analysis pinpointed 1,5‐anhydroglucitol as a partial intermediary in the influence LCT exhibits on telomere length. Circulating proteins play a pivotal role in influencing the aging process, making them promising candidates for therapeutic intervention. The implications of these proteins in aging warrant further investigation in future clinical research.

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Effect of aging on plasma 1,5-anhydroglucitol levels in humans and rats

Cited by 4 publications

References 24 publications

Effects of Sex and Age on Serum 1,5-anhydroglucitol in Nondiabetic Subjects

Effects of Sex and Age on Serum 1,5-anhydroglucitol in Nondiabetic Subjects

Development of an organ bath technique for isolated rat pancreas preparations to assess the effect of 1,5-AG on insulin secretion

Identification of prospective aging drug targets via Mendelian randomization analysis

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