Effect of Aging on the Quantitative Number of Brunner’s Glands

Nandagopalan, Pottayan Ayyappakutty; Magdalene, Kanapilly Francis; Areekal, Binu

doi:10.7860/jcdr/2014/7652.4087

Cited by 4 publications

(4 citation statements)

References 6 publications

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“…decreases(30%)withage [22].Thisage-relateddecrease in acid secretion is primarily related to a higher prevalence of chronic atrophic gastritis [23] and prolonged use of proton pump inhibitors in the elderly [24]. In humans,adeclineinacidsecretionmaypredisposethe small intestine to bacterial overgrowth [25].…”

Section: Stomachmentioning

confidence: 99%

“…Defects in intestinal barrier function can lead to persistent immune activation [4 ]. Ageing is associated with a decrease in the number of Brunner's glands in the duodenum; these produce an alkaline secretion that neutralizes the acid originating from the stomach and provides favourable pH conditions for the action of pancreatic juice enzymes [24]. Changes in luminal pH may influence drug solubility, particularly for ionisable compounds, and may affect different polymers used for drug delivery.…”

Section: Small Intestinal Digestion and Absorption Of Nutrientsmentioning

confidence: 99%

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The ageing gastrointestinal tract

Soenen

Rayner

Jones

et al. 2016

Current Opinion in Clinical Nutrition and Metabolic Care

185

113

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Alterations in gut function with ageing have particular implications for oesophageal, gastric, and colonic motility. Older individuals are particularly susceptible to malnutrition, postprandial hypotension, dysphagia, constipation, and faecal incontinence. Decrease in the number of nerve cells of the myenteric plexus that impact digestive absorption and the surface area of the small intestine because of degeneration of villi may lead to blunted absorption of nutrients. Impairment of the intestinal immune system as a result of ageing, including the mucosal layer of the gastrointestinal tract, appears to be a significant contributor to the age-related increase in the incidence and severity of infections.

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Section: Stomachmentioning

confidence: 99%

Section: Small Intestinal Digestion and Absorption Of Nutrientsmentioning

confidence: 99%

The ageing gastrointestinal tract

Soenen

Rayner

Jones

et al. 2016

Current Opinion in Clinical Nutrition and Metabolic Care

185

113

View full text Add to dashboard Cite

show abstract

“…The main changes observed are at the level of the stomach and distal gastrointestinal tract. At the level of the stomach, a decrease in acid secretion is described as a result of the increased prevalence of atrophic gastritis, which is enhanced by the chronic use of proton pump inhibitors in the older adult population [ 12 , 13 ]. All this generates an increase in pH, altering the solubilization of drugs that behave as weak acids or bases.…”

Section: Geriatric Pharmacologymentioning

confidence: 99%

Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy

Rojas-Solé,

Pinilla-González,

Lillo-Moya

et al. 2023

Redox Report

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Increased life expectancy, attributed to improved access to healthcare and drug development, has led to an increase in multimorbidity, a key contributor to polypharmacy. Polypharmacy is characterised by its association with a variety of adverse events in the older persons. The mechanisms involved in the development of age-related chronic diseases are largely unknown; however, altered redox homeostasis due to ageing is one of the main theories. In this context, the present review explores the development and interaction between different age-related diseases, mainly linked by oxidative stress. In addition, drug interactions in the treatment of various diseases are described, emphasising that the holistic management of older people and their pathologies should prevail over the individual treatment of each condition.

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“…Many studies reported no age-related structural changes in the small intestine, such as surface area, crypt depth, villous height, enterocytes, and brush border. The Brunner's gland in the duodenum, which produces an alkaline secretion providing the pH conditions for the activity of pancreatic enzyme, is decreased with aging, which affects the drug solubility by altering the luminal pH[59]. The regeneration ofsmall intestinal epithelium characterized by rapid turnover is compromised with aging, but the mucosal barrier function and permeability are not changed in the elderly compared with young individuals.…”

mentioning

confidence: 99%

Geriatric Physiology for Surgical Intensivists: Part I

2020

J Acute Care Surg

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According to a Korean National Statistics Office report, South Korea has become an aged society with 14% of the population aged 65 years and over, and it is expected to become a superaged society by 2026 which would be at the fastest pace in the world [1]. Population aging and extended life expectancy have raised concerns about distinguishing disease states from normal aging when encountering this population in a clinical situation. Aging is usually defined as an age-dependent or an age-progressive decline in intrinsic physiological function necessary for survival and fertility. Aging leads to inevitable deterioration in cellular and physiological function, which results in impaired homeostasis, decreased ability to adapt to stress, increased vulnerability to disease, and increased age-related mortality [2]. The characteristics of aging as distinguished from diseases of aging, do not generally cause symptoms and occur at different rates among individuals, and within individuals. A large variation in physiological

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Effect of Aging on the Quantitative Number of Brunner’s Glands

Cited by 4 publications

References 6 publications

The ageing gastrointestinal tract

The ageing gastrointestinal tract

Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy

Geriatric Physiology for Surgical Intensivists: Part I

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