Effect of aging on vagus somatosensory evoked potentials and ultrasonographic parameters of the vagus nerve

Laucius, Ovidijus; Gabrinovičienė, Radvilė; Jucevičiūtė, Neringa; Vaitkus, Antanas; Balnytė, Renata; Petrikonis, Kęstutis; Rastenytė, Daiva

doi:10.1016/j.jocn.2021.03.048

Cited by 5 publications

(5 citation statements)

References 26 publications

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“…Right, left, and average vagus nerve cross-sectional areas were not significantly different between the two age groups. The older group demonstrated slower vagus somatosensory evoked potential (VSEP) latencies (Laucius et al, 2021). These VSEP results partially replicated previous research, which also demonstrated slower VSEP latencies in older adults (51-73 years) versus younger participants (20-40 years) (Fallgatter et al, 2005).…”

Section: Vagus Nerve and Agingsupporting

confidence: 83%

Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging

et al. 2023

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Evidence for clinically meaningful benefits of transcutaneous vagus nerve stimulation (VNS) has been rapidly accumulating over the past 15 years. This relatively novel non-invasive brain stimulation technique has been applied to a wide range of neuropsychiatric disorders including schizophrenia, obsessive compulsive disorder, panic disorder, post-traumatic stress disorder, bipolar disorder, and Alzheimer’s disease. More recently, non-invasive forms of VNS have allowed for investigations within healthy aging populations. These results offer insight into protocol considerations specific to older adults and how to translate those results into effective clinical trials and, ultimately, effective clinical care. In this review, we characterize the possible mechanisms by which non-invasive VNS may promote healthy aging (e.g., neurotransmitter effects, inflammation regulation, functional connectivity changes), special considerations for applying non-invasive VNS in an older adult population (e.g., vagus nerve changes with age), and how non-invasive VNS may be used in conjunction with existing behavioral interventions (e.g., cognitive behavioral therapy, cognitive training) to promote healthy emotional and cognitive aging.

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Section: Vagus Nerve and Agingsupporting

confidence: 83%

Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging

et al. 2023

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“…Moreover, the participants in our study were older than previously studied cohorts, as only participants aged 65 years or older were included. Pelz et al reported that the CSA of the VN was inversely correlated with age [20], although another study, conducted by Laucius et al, failed to find any differences in VN CSA between younger and older age cohorts [26]; however, the maximum age of the subjects in the latter study was 55 years. Thus, the relatively small CSA of the VN observed in the present study may have been related to the advanced age of the participants.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound evaluation of vagus nerve cross-sectional area in a community-dwelling elderly Japanese cohort

Oura

Akasaka

Ishizuka

et al. 2023

Preprint

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Objectives Although the vagus nerve (VN) is easily observed by ultrasonography, few studies have evaluated the cross-sectional area (CSA) of the VN in healthy older individuals from East Asia. In this study, we aimed to report reference values for the CSA of the VN in community-dwelling elderly Japanese individuals and to identify any associated medical history and/or lifestyle factors. Methods The present study included 336 participants aged >= 65 years from a prospective cohort study conducted in Yahaba, Japan from October 2021 to February 2022. The CSA of the VN was measured bilaterally at the level of the thyroid gland by ultrasonography. Univariate and multivariable linear regression analyses were conducted to identify the associations between clinical and background factors and the CSA of the VN on each side. Results In our cohort, the median CSA of the VN was 1.3 mm2 (interquartile range [IQR] 1.1–1.6) on the right side and 1.2 mm2 (IQR 1.0–1.4) on the left side. Multivariable linear regression analysis showed that history of head injury (β = -0.15, p < .01), history of convulsion (β = 0.19, p < .01), and BMI (β = 0.30, p < .01) were independently associated with the CSA of the VN on the left side. In contrast, there were no independent associations between any of the assessed variables and the CSA on the right side. Conclusion We have reported reference VN CSA values for community-dwelling elderly Japanese individuals. In addition, we showed that the CSA of the VN on the left side was positively associated with a history of convulsive seizure and BMI and inversely associated with a history of head injury.

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“…Moreover, the participants in our study were older than previously studied cohorts, as only participants aged 70 years or older were included. Pelz et al reported that the CSA of the VN was inversely correlated with age [ 21 ], although another study, conducted by Laucius et al, failed to find any differences in VN CSA between younger and older age cohorts [ 26 ]; however, the maximum age of the subjects in the latter study was 55 years. Thus, the relatively small CSA of the VN observed in the present study may have been related to the advanced age of the participants.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound evaluation of vagus nerve cross-sectional area in a community-dwelling elderly Japanese cohort

et al. 2023

View full text Add to dashboard Cite

Objectives Although the vagus nerve (VN) is easily observed by ultrasonography, few studies have evaluated the cross-sectional area (CSA) of the VN in healthy older individuals from East Asia. In this study, we aimed to report reference values for the CSA of the VN in community-dwelling elderly Japanese individuals and to identify any associated medical history and/or lifestyle factors. Methods The present study included 336 participants aged ≥ 70 years from a prospective cohort study conducted in Yahaba, Japan from October 2021 to February 2022. The CSA of the VN was measured bilaterally at the level of the thyroid gland by ultrasonography. Simple linear regression analysis and generalized estimating equation were conducted to identify the associations between clinical and background factors and the CSA of the VN. Results In our cohort, the median CSA of the VN was 1.3 mm2 (interquartile range [IQR] 1.1–1.6) on the right side and 1.2 mm2 (IQR 1.0–1.4) on the left side. Generalized estimating equation showed that history of head injury (β = 0.19, p < .01), current smoking habit (β = -0.09, p = .03), and BMI (β = 0.02, p < .01) were independently associated with the CSA of the VN. Conclusion We have reported reference VN CSA values for community-dwelling elderly Japanese individuals. In addition, we showed that the CSA of the VN was positively associated with a history of head injury and BMI and inversely associated with current smoking habit.

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Effect of aging on vagus somatosensory evoked potentials and ultrasonographic parameters of the vagus nerve

Cited by 5 publications

References 26 publications

Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging

Impact of transcutaneous vagus nerve stimulation on healthy cognitive and brain aging

Ultrasound evaluation of vagus nerve cross-sectional area in a community-dwelling elderly Japanese cohort

Ultrasound evaluation of vagus nerve cross-sectional area in a community-dwelling elderly Japanese cohort

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