Effect of Agitation and Aeration on Keratinase Production in Bioreactors Using Bioprocess Engineering Aspects

Deniz, İrem; Demir, Tuğçe; Öncel, Suphi Ş.; Hameş, Elif Esin; Vardar‐Sukan, Fazilet

doi:10.1007/s10930-021-09978-5

Cited by 3 publications

(2 citation statements)

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“…Fermentation parameters such as carbon source, nitrogen source, temperature, and others need to be optimized as these parameters have an impact on the production of the keratinase. Wastes from industries such as feathers can be added into the cultural medium ( Deniz et al, 2021 ). In addition, other wastes such as wheat and soy beans can be used as a substrate for producing keratinases ( Syed et al, 2009 ; Prakash et al, 2010a ).…”

Section: Mechanism Of Action For Keratinasementioning

confidence: 99%

“…Interestingly, a study showed that glucose and ammonium nitrate are not good sources for growing Stenotrophomonas maltophilia to degrade feathers ( Qu et al, 2018 ). Accumulated studies suggest that different microorganisms require various fermentation conditions for large-scale production, indicating that careful exploratory studies are necessary prior to the large-scale production of the enzymes ( Jagadeesan et al, 2020 ; de Menezes et al, 2021 ; Deniz et al, 2021 ; Sharma and Kango, 2021 ). It was demonstrated that the solid-state fermentation increased keratinase production compared with the commonly used submerged fermentation ( Inácio et al, 2018 ).…”

Section: Mechanism Of Action For Keratinasementioning

confidence: 99%

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Structure, Application, and Biochemistry of Microbial Keratinases

2021

Front. Microbiol.

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Keratinases belong to a class of proteases that are able to degrade keratins into amino acids. Microbial keratinases play important roles in turning keratin-containing wastes into value-added products by participating in the degradation of keratin. Keratin is found in human and animal hard tissues, and its complicated structures make it resistant to degradation by common proteases. Although breaking disulfide bonds are involved in keratin degradation, keratinase is responsible for the cleavage of peptides, making it attractive in pharmaceutical and feather industries. Keratinase can serve as an important tool to convert keratin-rich wastes such as feathers from poultry industry into diverse products applicable to many fields. Despite of some progress made in isolating keratinase-producing microorganisms, structural studies of keratinases, and biochemical characterization of these enzymes, effort is still required to expand the biotechnological application of keratinase in diverse fields by identifying more keratinases, understanding the mechanism of action and constructing more active enzymes through molecular biology and protein engineering. Herein, this review covers structures, applications, biochemistry of microbial keratinases, and strategies to improve its efficiency in keratin degradation.

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Section: Mechanism Of Action For Keratinasementioning

confidence: 99%