Effect of Agmatine on a mouse model of allergic airway inflammation: A comparative study

ElMahdy, Mohammed Kh.; Abdеlaziz, Rania R.; Elmahdi, Hoda S.; Suddеk, Ghada M.

doi:10.1080/08916934.2022.2093864

Autoimmunity

2022

DOI: 10.1080/08916934.2022.2093864

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Effect of Agmatine on a mouse model of allergic airway inflammation: A comparative study

Mohammed Kh. ElMahdy

Rania R. Abdеlaziz

Hoda S. Elmahdi

et al.

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2024

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The role of inflammasomes in human diseases and their potential as therapeutic targets

Yao,

Sterling,

Wang

et al. 2024

Sig Transduct Target Ther

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Inflammasomes are large protein complexes that play a major role in sensing inflammatory signals and triggering the innate immune response. Each inflammasome complex has three major components: an upstream sensor molecule that is connected to a downstream effector protein such as caspase-1 through the adapter protein ASC. Inflammasome formation typically occurs in response to infectious agents or cellular damage. The active inflammasome then triggers caspase-1 activation, followed by the secretion of pro-inflammatory cytokines and pyroptotic cell death. Aberrant inflammasome activation and activity contribute to the development of diabetes, cancer, and several cardiovascular and neurodegenerative disorders. As a result, recent research has increasingly focused on investigating the mechanisms that regulate inflammasome assembly and activation, as well as the potential of targeting inflammasomes to treat various diseases. Multiple clinical trials are currently underway to evaluate the therapeutic potential of several distinct inflammasome-targeting therapies. Therefore, understanding how different inflammasomes contribute to disease pathology may have significant implications for developing novel therapeutic strategies. In this article, we provide a summary of the biological and pathological roles of inflammasomes in health and disease. We also highlight key evidence that suggests targeting inflammasomes could be a novel strategy for developing new disease-modifying therapies that may be effective in several conditions.

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The role of inflammasomes in human diseases and their potential as therapeutic targets

Yao,

Sterling,

Wang

et al. 2024

Sig Transduct Target Ther

View full text Add to dashboard Cite

show abstract

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Effect of Agmatine on a mouse model of allergic airway inflammation: A comparative study

Cited by 1 publication

References 57 publications

The role of inflammasomes in human diseases and their potential as therapeutic targets

The role of inflammasomes in human diseases and their potential as therapeutic targets

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