Effect of air bubbles localization and migration after embryo transfer on assisted reproductive technology outcome

Fıçıcıoğlu, Cem; Özcan, Pınar; Koçer, Melis G.; Yeşiladalı, Mert; Alagöz, Oya; Özkara, Gülçin; Tayyar, Ahter Tanay; Altunok, Çiğdem

doi:10.1016/j.fertnstert.2017.10.032

Cited by 15 publications

(12 citation statements)

References 16 publications

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“…The embryo flash movement from the fundus toward the cervix was also related to significantly lower PR and implantation rate. Fıçıcıoğlu et al 23 evaluated the effect of embryo flash position and movement of the air bubbles at 1 and 60 minutes after ET on PR. They reported that PR was associated with embryo flash movement and migration, and the PR was dramatically reduced when the embryo migrated from its original position toward the cervix at 60 minutes.…”

Section: Discussionmentioning

confidence: 99%

“…The self‐evaluation rating was categorized into three levels (A: excellent, B: moderate, and C: poor), based on the impression of the physician who performed FET; this comprised the smoothness of the procedure, the absence of pain or bleeding, avoiding the use of hard uterine forceps, and whether the position of the air bubble was as planned. Based on the previous reports, the targeted air bubble position was set between 5 and 15 mm from the fundus 21‐23 …”

Section: Methodsmentioning

confidence: 99%

“…Based on the previous reports, the targeted air bubble position was set between 5 and 15 mm from the fundus. 21,22,23 The primary outcome of this study was clinical pregnancy. Serum human chorionic gonadotropin was evaluated 10 days after FET.…”

Section: Materials S and Me Thodsmentioning

confidence: 99%

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Predictive factors influencing pregnancy rate in frozen embryo transfer

Hayashi

Enatsu

Iwasaki

et al. 2020

Reprod Medicine & Biology

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Purpose To evaluate the outcomes of embryo transfer (ET) and to identify the parameters influencing pregnancy outcomes. Methods This study included 938 ET cycles involving single frozen and thawed good‐quality blastocyst (Gardner grade ≥3BB) between August 2017 and January 2018. The significance of several parameters including endometrial thickness, position of the transferred air bubble, self‐evaluation score by physicians, and uterus direction at ET as predictors of clinical pregnancy was evaluated using univariate and multivariate analyses. Results Among 938 ET cycles, 462 (49.3%) resulted in a clinical pregnancy. Endometrial thickness was positively associated with clinical pregnancy in a linear trend. Between the variable position of the transferred air bubble and clinical pregnancy rate showed a curvilinear relationship. Clinical pregnancy rate was higher in cases with good self‐evaluation score, whereas there was no difference between groups with different uterus directions. Univariate analysis of predictive parameters identified endometrial thickness, self‐evaluation score by physicians, and position of air bubbles as significant predictors of clinical pregnancy, of which endometrial thickness and position of air bubbles appeared to be independently related to clinical pregnancy. Conclusion Endometrial thickness and the position of transferred air bubbles influenced clinical pregnancy in ET cycles.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Predictive factors influencing pregnancy rate in frozen embryo transfer

Hayashi

Enatsu

Iwasaki

et al. 2020

Reprod Medicine & Biology

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“…Thus, a major outcome of this study, and of previous studies [11,21], is that dynamic transport of the transferred matter is dependent on the position of the sagittal cross-section of the uterine cavity with respect to the horizontal. Fıçıcıoğlu et al [22] reported that the clinical pregnancy rate was remarkably reduced when the embryo migrated from its original position toward the cervix 60 minutes after ET. Thus, a patient-specific position is recommended during the ET procedure to ensure that the fundus is at the highest point above the horizontal.…”

Section: Transferred Mattermentioning

confidence: 99%

“…To date, the majority of studies on the air bubble seem to suggest that pregnancy rates are highest when the air bubbles are closer to the fundus [19,26]. Fıçıcıoğlu et al [22] also reported that air bubbles moving toward the fundus 60 minutes after catheter withdrawal were associated with higher clinical pregnancy rates [22]. Notably, the association of air bubble location and embryo deposition seems controversial.…”

Section: Air Bubblementioning

confidence: 99%

Embryo location in the uterus during embryo transfer: An in vitro simulation

Yang

Xia

et al. 2020

PLoS ONE

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Objective To evaluate the location of transferred embryos under various parameters during embryo transfer in in vitro fertilization (IVF) by applying an in vitro experimental model for embryo transfer (ET). Methods Mock ET simulations were conducted with a laboratory model of the uterine cavity. The transfer catheter was loaded with a sequence of air and liquid volumes, including development-arrested embryos donated by patients. The transfer procedure was recorded using a digital video camera. An orthogonal design, including three independent variables (uterine orientation, distance of the catheter tip to the fundus, and injection speed) and one dependent variable (final embryo position), was applied. Results The uterine cavity was divided into six regions. The distribution of the transferred matter within the uterine cavity varied according to the uterine orientation. Medium speed-injected embryos were mostly found in the static region while fast-and slow-speed injected embryos were mostly found in the fundal region and the cervical-left region, respectively. The possibility of embryo separation from the air bubble increased from 11.1% in slow injection cases to 29.6% and 48.1% in medium and fast injection cases, respectively. Conclusion The experimental model provides a new method for investigating ET procedures. Fast injection of embryos into a retroverted uterus may be more likely to result in embryo separation from the air bubble.

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Ideal embryo transfer position and endometrial thickness in IVF embryo transfer treatment

Wang

Zhu

Sun

et al. 2018

Intl J Gynecology & Obste

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Objective To establish an ideal transfer strategy by investigating the relationships among embryo transfer (ET) depth, endometrial thickness, and subsequent in vitro fertilization treatment clinical pregnancy outcomes. Methods In the present retrospective analysis, data from in vitro fertilization‐ET treatment cycles conducted at a fertility center in Shanghai, China, between October 2014 and March 2015 were analyzed. Women were divided into groups 1–4 according to transfer depth (<10; 10–15, 15–20, and >20 mm, respectively), as measured by air bubbles. Additionally, 391 women were divided into groups A–C according to endometrial thickness (<7, 1–12, and >12 mm, respectively). Clinical pregnancy outcomes were assessed by group. Results Data from 501 cycles were included. Clinical pregnancy and live delivery rates were significantly higher in group 2 (P=0.009 and P=0.002, respectively) and group 3 (P=0.008 and P=0.001, respectively) than in group 4. Among the 394 patients with endometrial thickness data available, clinical pregnancy and live delivery rates were higher in group B (P=0.028 and P=0.015, respectively) and group (P=0.013 and P=0.013, respectively) than in group A. Conclusion Correct transfer depth and endometrial thickness can increase the rates of clinical pregnancy, implantation, and live delivery. Placing the embryos at 10–20 mm from the fundus and at an endometrial thickness of more than 7 mm is recommended for optimal clinical pregnancy outcomes.

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Effect of air bubbles localization and migration after embryo transfer on assisted reproductive technology outcome

Cited by 15 publications

References 16 publications

Predictive factors influencing pregnancy rate in frozen embryo transfer

Predictive factors influencing pregnancy rate in frozen embryo transfer

Embryo location in the uterus during embryo transfer: An in vitro simulation

Ideal embryo transfer position and endometrial thickness in IVF embryo transfer treatment

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