Effect of Ala54Thr polymorphism of FABP2 on anthropometric and biochemical variables in response to a moderate-fat diet

Martínez-López, Érika; García-García, Maritza Roxana; Gonzalez-Avalos, Jorge M.; Maldonado-González, Montserrat; Ruíz-Madrigal, Bertha; Vizmanos, Bárbara; Hernández‐Nazará, Zamira H.; Román, Sonia; Panduro, Arturo

doi:10.1016/j.nut.2012.03.002

Cited by 25 publications

(26 citation statements)

References 27 publications

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“…Moreover, an intervention with a hypocaloric diet enriched with polyunsaturated fatty acid produce in Thr54 carriers a better metabolic response than non-carriers. Other further studies have demonstrated the same paradoxical better response in Thr54 carriers than no carriers with a hypocaloric diet low in SFA [23]. However, a lack of association of metabolic response secondary to weight loss with this polymorphism has been described in other interventional studies [24].…”

Section: Discussionmentioning

confidence: 83%

Role of Fatty Acid-Binding Protein 2 Ala54Thr Genotype on Weight Loss and Cardiovascular Risk Factors after a High-Protein/Low-Carbohydrate versus a Standard Hypocaloric Diet during 9 Months

Luis

Izaola²,

Fuente³

et al. 2015

Ann Nutr Metab

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Background: It has been found that the expression of fatty acid-binding protein 2 gene mRNA is under dietary control. The polymorphism Ala54Thr of this protein was associated with high insulin resistance. Objective: The aim of our study was to investigate the influence of Thr54 polymorphism on metabolic response, weight loss and serum adipokine levels secondary to high-protein/low-carbohydrate vs. standard hypocaloric diets during 9 months. Design: A population of 193 obese subjects was analyzed in a randomized trial. A nutritional evaluation was performed at the beginning and at the end of a 9-month period in which subjects received 1 of 2 diets (diet HP: high-protein/low-carbohydrate vs. diet S: standard diet). Results: With both diets and in both genotype groups, body mass index, weight, fat mass, waist circumference, systolic blood pressure and leptin levels decreased. With both diets and only in wild genotype (diet HP vs. diet S), glucose (-6.2 ± 2.1 vs. -4.9 ± 2.0 mg/dl; p < 0.05), insulin levels (-5.0 ± 3.9 vs. -2.0 ± 2.1 UI/l; p < 0.05), homeostasis model assessment for insulin resistance (HOMA-R) (-1.1 ± 0.9 vs. -0.7 ± 1.0 units; p < 0.05) decreased. The improvement in these parameters was higher with diet HP than HS. With both diets and only in the wild genotype, total cholesterol and LDL-total cholesterol levels decreased. Conclusion: Carriers of Thr54 allele have a different metabolic response after weight loss than wild type non-A carriers obese, with a lack of decrease of LDL-cholesterol, glucose, insulin levels and HOMA-R.

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Section: Discussionmentioning

confidence: 83%

Role of Fatty Acid-Binding Protein 2 Ala54Thr Genotype on Weight Loss and Cardiovascular Risk Factors after a High-Protein/Low-Carbohydrate versus a Standard Hypocaloric Diet during 9 Months

Luis

Izaola²,

Fuente³

et al. 2015

Ann Nutr Metab

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“…BMI, waist circumference) and biochemical (e.g. HOMA-IR, total cholesterol) factors (46) (47). In addition, the exact fat composition appears to be critical for an optimal response, as improved anthropometric changes were replicated in Ala54Thr individuals fed a hypocaloric diet that was high in monounsaturated fats, while under this paradigm biochemical factors responded significantly poorer than controls (48).…”

Section: Clinically Relevant Polymorphisms Within the Fabp Familymentioning

confidence: 99%

Fatty acid binding proteins

Thumser¹,

Moore

Plant³

2014

Current Opinion in Clinical Nutrition and Metabolic Care

157

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“…Metabolic responses of individuals depend on many factors like the relation between genetic variants and nutrients also known as gene-nutrient interaction [26]. …”

Section: Discussionmentioning

confidence: 99%

Interaction of Vitamin E Intake and Pro12Ala Polymorphism of <b><i>PPARG</i></b> with Adiponectin Levels

et al. 2017

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Background/Aim: One of the beneficial effects associated with vitamin E intake is the enhancement of peroxisome proliferator-activated receptor gamma (PPARγ) activity and the consequent upregulation of adiponectin expression. The aim of this study was to analyze the adiponectin levels in subjects with the Pro12Ala polymorphism of PPARG according to vitamin E intake. Methods: A total of 283 subjects were enrolled. Total vitamin E intake was estimated based on a validated 3-day food consumption record and analyzed using Nutritionist Pro^TM software. The Pro12Ala polymorphism (rs1801282) was determined by allelic discrimination. The adiponectin levels were measured by an ELISA assay. Results: Vitamin E intake was deficient in all subjects (1.50 ± 1.78 mg/day). Subjects with higher vitamin E intake levels and the Pro12Ala/Ala12Ala genotype had statistically significant higher levels of serum adiponectin than subjects with the Pro12Pro genotype (4.4 [3.2–5.7] vs. 2.7 [2.0–3.5] μg/mL; p = 0.024). Conclusions: Our results suggest that increased consumption of vitamin E should be encouraged since it has been reported that vitamin E promotes adiponectin expression via PPARγ activation. Subjects with Pro12Pro genotype had lower serum adiponectin levels than subjects with Pro12Ala/Ala12Ala genotype; therefore, they might be at higher risk of developing metabolic complications.

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Effect of Ala54Thr polymorphism of FABP2 on anthropometric and biochemical variables in response to a moderate-fat diet

Cited by 25 publications

References 27 publications

Role of Fatty Acid-Binding Protein 2 Ala54Thr Genotype on Weight Loss and Cardiovascular Risk Factors after a High-Protein/Low-Carbohydrate versus a Standard Hypocaloric Diet during 9 Months

Role of Fatty Acid-Binding Protein 2 Ala54Thr Genotype on Weight Loss and Cardiovascular Risk Factors after a High-Protein/Low-Carbohydrate versus a Standard Hypocaloric Diet during 9 Months

Fatty acid binding proteins

Interaction of Vitamin E Intake and Pro12Ala Polymorphism of <b><i>PPARG</i></b> with Adiponectin Levels

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