Effect of Alcohol (Ethanol) Administration on Sex-Hormone Metabolism in Normal Men

Gordon, G G; Altman, Kurt I.; Southren, A. Louis; Rubin, Emanuel; Lieber, Charles S.

doi:10.1056/nejm197610072951501

Cited by 349 publications

(96 citation statements)

References 28 publications

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“…(Glantz, 1964). Alcohol depresses testosterone levels (Gordon et al, 1976) and liver disease leads to hyperoestrogenism (Sites & MacDonald, 1974). The studies of Ogawa (1964Ogawa ( , 1967 (Greenwald et al, 1974).…”

Section: Resultsmentioning

confidence: 99%

Descriptive epidemiology of testicular and prostatic cancer in Los Angeles

Ross¹,

McCurtis²,

Be³

et al. 1979

Br J Cancer

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Summary.-Data from the Los Angeles County Cancer Surveillance Program (CSP) from 1972 to 1975 were used to study the descriptive epidemiology of testicular cancer and prostatic cancer. The very high black/white ratio and late age peak of cancer of the prostate contrasted sharply with the very low ratio and early age peak of testicular cancer. However, both sites had higher rates among upper occupational and social class groupings. Available descriptive and analytical research suggests that the etiology of prostatic cancer is most probably related to hormonal influences rather than to a horizontally transmitted agent, while the etiology of testicular cancer is most probably related to endogenous or exogenous hormonal influences in utero or in infancy, or to in utero exposure to other exogenous agents.

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Section: Resultsmentioning

confidence: 99%

Descriptive epidemiology of testicular and prostatic cancer in Los Angeles

Ross¹,

McCurtis²,

Be³

et al. 1979

Br J Cancer

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“…The deleterious effects of alcohol on male sexual function are well documented (1,2). The relation between chronic alcohol abuse and male impotence, sterility, and feminized bodily habitus is widely recognized (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

“…The relation between chronic alcohol abuse and male impotence, sterility, and feminized bodily habitus is widely recognized (3)(4)(5). The mechanisms of alcohol-induced male sexual dysfunction have been explored, and have been shown to be related both to primary testicular failure and to suppression of hypothalamic-pituitary responsiveness (2,6,7).…”

Section: Introductionmentioning

confidence: 99%

Alcohol-Induced Ovarian Failure in the Rat

Thiel¹,

Gavaler²,

Lester³

et al. 1978

J. Clin. Invest.

122

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A B S T R A C T The effect of ethanol feeding on ovarian function and structure in fenmale rats was studied in alcohol-fed animals, isocalorically fed controls, and two ad libitum-fed control groups. Ovarian weight was reduced by 60% in alcohol-fed animals compared with the control groups. Gross disruption of ovarian architecture was noted, characterized by the absence of any corpus hemorrhagicum and corpus albicans. Moreover, plasma levels of estradiol were significantly reduced in the alcohol-fed animals (P < 0.01) compared with the levels found in isocaloric controls. Plasma levels of estrone and corticosterone were increased in alcoholfed and isocaloric control animals relative to those of ad libitum-fed animals suggesting a primarily adrenal, rather than ovarian, origin for these two steroids. Despite the increase in estrone, the secondary sex organs (uterus and fallopian tubes) reflected marked estrogen deprivation presumably as a result of estradiol insufficiency.Progesterone levels in the alcohol-fed animals were significantly less than levels in the isocaloric and intact ad libitum-fed controls but were not significantly different compared to oophorectomized animals.Plasnma follicle-stimulating hormone levels were sinmilar in alcohol-fed, isocaloric controls, and ad libitum-intact controls. They were, however, one-third the level ofoophorectomized controls. Both alcohol-fed anid isocaloric controls had increased levels of plasma luteinizing hormone, although levels were below those seen in oophorectomized controls (P < 0.01).The results establish that ingestion of a diet containing 5% ethanol for periods as short as 6 wk produces functional and histologic ovarian failure in the female rat.Dr. V'an Thiel is the recipient of U. S. Public Health Service Career Developmiient Award AA00016.

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“…Serum testosterone concentration is lowered for up to several hours after acute ethanol administration (18,29). Although the majority of studies involving humans show no ethanol effect on serum luteinizing hormone (LH), some data have demonstrated an increase while others have supported a decrease (16,29).Also, as a result of increased adrenomedullary and sympathetic nervous system stimulation, resistance exercise results in increased 5-min postexercise catecholamine concentrations (23,25). Urinary and plasma concentrations of catecholamines are increased in response to acute ethanol administration (1,34).…”

mentioning

confidence: 99%

mentioning

confidence: 99%

Effect of acute postexercise ethanol intoxication on the neuroendocrine response to resistance exercise

Koziris

Kraemer

Gordon

et al. 2000

Journal of Applied Physiology

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don, Thomas Incledon, and Howard G. Knuttgen. Effect of acute postexercise ethanol intoxication on the neuroendocrine response to resistance exercise. J. Appl. Physiol. 88: 165-172, 2000.-This investigation was conducted to determine the effect of postexercise ethanol intoxication (21.97 Ϯ 1.09 mmol/l blood) on the response of selected aspects of the neuroendocrine system to a resistance exercise (Ex) session. Nine resistance-trained men (25.0 Ϯ 1.4 yr, 179.4 Ϯ 3.4 cm, 79.7 Ϯ 3.3 kg) were used to compare three 3-day treatments: control, Ex, and ethanol after exercise (ExEt). Blood was collected serially from an antecubital vein before exercise, immediately after exercise, and for pooled analysis at 20-40 (2 samples), 60-120 (4 samples), and 140-300 (9 samples) min after exercise on day 1 and in the morning (2 samples each) on days 2 and 3. Ethanol did not increase circulating epinephrine, norepinephrine, or cortisol concentration (Cort) above Ex elevations. At 60-120 min, only ExEt Cort was greater than control Cort. Concentrations of testosterone, luteinizing hormone, and corticotropin were not affected by either treatment. It is concluded that, although this blood ethanol concentration is insufficient to acutely increase Cort above that caused by Ex alone, it appears that ethanol may have a prolonged effect beyond the Ex response. This blood ethanol concentration does not further stimulate the sympathoadrenal system during the postexercise response.anabolic; catabolic; alcohol; lactate; stress response THE EFFECTS OF ETHANOL vary and can depend on the extent of its consumption and environmental context. In addition to its acute effects, ethanol can impede physical performance when its consumption is of a chronically abusive nature, i.e., alcoholism. It has been known for some time that individuals diagnosed with alcohol dependence have displayed various degrees of muscle damage and weakness (26, 37).The neuroendocrine system, and specifically the interaction of various anabolic (14) and catabolic hormones (2, 19), is part of the response to resistance exercise. This system, which has a role in the maintenance and adaptation of muscular tissue and strength, is also among the many systems affected by acute (1, 27, 32) and chronic ethanol abuse (28,32).With regard to the pituitary-adrenocortical axis, increased postexercise cortisol concentrations have been shown consequent to acute resistance exercise (15, 17). Ethanol ingestion results in elevated circulating cortisol concentrations, and there is apparently a doserelated effect (13, 32). Although there is evidence to suggest that the effect of ethanol on this axis occurs via corticotropin-releasing hormone (CRH) secretion from hypothalamic neurons (35) via adrenergic stimulation of higher centers (41), there is evidence to indicate that ethanol's effect is instead mediated via an increase in ACTH release from the anterior pituitary gland (18,33).In the pituitary-gonadal axis of men, testosterone is thought to have a role in the adaptation to resistance exercis...

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Effect of Alcohol (Ethanol) Administration on Sex-Hormone Metabolism in Normal Men

Cited by 349 publications

References 28 publications

Descriptive epidemiology of testicular and prostatic cancer in Los Angeles

Descriptive epidemiology of testicular and prostatic cancer in Los Angeles

Alcohol-Induced Ovarian Failure in the Rat

Effect of acute postexercise ethanol intoxication on the neuroendocrine response to resistance exercise

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