The aim of this study was to determine the effect of caffeine on the reaction time on the optic stimulus in men. The study group had 10 people aged 25 to 30 years. The reaction time was measured with a precision measuring meter at 1 millisecond. Caffeine was administered with 100 mg and 200 mg tablets. After 100 mg of caffeine after an hour there was decrease from 352 ms to a value of 336 (decrease by 16 ms, 4,5%). After two hours there was again a slight decrease of 8 ms to 328 ms (total of 24 ms, 6,8%). Caffeine reduces the reaction time and its effect is evident for an hour and two hours after administration. After finding the quiescent values of rection time of 348 ms, 200 mg of caffeine was given, and the subsequent measurement after 1 hour showed a reducing in the reaction time to 328 ms (20 ms). Measurement after two hours showed approximately the same value of 332 ms -as after one hour.