Effect of Alcohol Withdrawl on Glutathione S-transferase, Total Antioxidant Capacity and Amylase in Blood and Saliva of Alcohol-Dependent Males

Peter, N.

doi:10.7860/jcdr/2013/4658.2942

Cited by 12 publications

(10 citation statements)

References 19 publications

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“…The highest sensitivity of up to 99% was observed for Peth 31, 41 that showed a rapid decrease at the beginning of withdrawal, a slow decline after the first few days, and persistence at low levels beyond 19d of abstinence 42. Apart from biomarkers detected in blood and urine samples, saliva is a promising and easy accessible material to detect glycomarkers of oxidative stress,43, 44 but the reproducibility and validity in Peth has to be proven for clinical routine application 45. As an antibody based flash test is available for detection of EtG in urine with good sensitivity and specificity, this parameter is the most promising one to be integrated in routine laboratory settings and in screening of patients at risk to develop AWS 46…”

Section: Biomarkersmentioning

confidence: 99%

Alcohol withdrawal syndrome: mechanisms, manifestations, and management

et al. 2016

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The alcohol withdrawal syndrome is a well‐known condition occurring after intentional or unintentional abrupt cessation of heavy/constant drinking in patients suffering from alcohol use disorders (AUDs). AUDs are common in neurological departments with patients admitted for coma, epileptic seizures, dementia, polyneuropathy, and gait disturbances. Nonetheless, diagnosis and treatment are often delayed until dramatic symptoms occur. The purpose of this review is to increase the awareness of the early clinical manifestations of AWS and the appropriate identification and management of this important condition in a neurological setting.

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Section: Biomarkersmentioning

confidence: 99%

Alcohol withdrawal syndrome: mechanisms, manifestations, and management

et al. 2016

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“…On the contrary, alcohol-dependent subjects showed significantly lower TAC in blood and saliva as compared to those in the controls and the alcohol withdrawal caused an increase in the TAC to near-control values [ 102 ].…”

Section: Age Gender and Lifestyle Factorsmentioning

confidence: 99%

Salivary and Urinary Total Antioxidant Capacity as Biomarkers of Oxidative Stress in Humans

Peluso

Raguzzini

2016

Pathology Research International

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Total Antioxidant Capacity (TAC) is a biomarker often used in order to investigate oxidative stress in many pathological conditions. Saliva and urine can be collected noninvasively and represent attractive diagnostic fluids for detecting biomarkers of various pathological conditions. The reviewed case-control and intervention studies that measured salivary or urinary TAC revealed that diseases, antioxidant foods, or supplements and age, gender, and lifestyle factors influenced salivary or urinary TAC. Salivary and urinary TAC were particularly affected by oral or renal status, respectively, as well as by infection; therefore these factors must be taken into account in both case-control and intervention studies. Furthermore, some considerations on sample collection and normalization strategies could be made. In particular, unstimulated saliva could be the better approach to measure salivary TAC, whereas 24 h or spontaneous urine collection should be chosen on the basis of the study outcome and of the creatinine clearance. Finally, the uric acid-independent TAC could be the better approach to evaluate red-ox status of body, in particular after nutritional interventions and in diseases associated with hyperuricaemia.

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“…Lower doses of alcohol administered in an intermittent fashion across 90 days also produced reductions in total GSH levels and increases in oxidized proteins and lipids in cortex and cerebellum [81]. Evidence has demonstrated that individuals with alcohol use disorders (AUDs) have decreased GSH activity and reduced plasma and salivary content of GST [82,83]. However, some studies have reported increased GST activity in blood of alcoholics [84,85].…”

Section: Drugs Of Abuse and Oxidative/nitrosative Stressmentioning

confidence: 99%

Glutathione and redox signaling in substance abuse

Uys

Mulholland

Townsend

2014

Biomedicine & Pharmacotherapy

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Throughout the last couple decades, the cause and consequences of substance abuse has expanded to identify the underlying neurobiological signaling mechanisms associated with addictive behavior. Chronic use of drugs, such as cocaine, methamphetamine and alcohol leads to the formation of oxidative or nitrosative stress (ROS/RNS) and changes in glutathione and redox homeostasis. Of importance, redox-sensitive post-translational modifications on cysteine residues, such as S-glutathionylation and S-nitrosylation could impact on the structure and function of addiction related signaling proteins. In this commentary, we evaluate the role of glutathione and redox signaling in cocaine-, methamphetamine- and alcohol addiction and conclude by discussing the possibility of targeting redox pathways for the therapeutic intervention of these substance abuse disorders.

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Effect of Alcohol Withdrawl on Glutathione S-transferase, Total Antioxidant Capacity and Amylase in Blood and Saliva of Alcohol-Dependent Males

Cited by 12 publications

References 19 publications

Alcohol withdrawal syndrome: mechanisms, manifestations, and management

Alcohol withdrawal syndrome: mechanisms, manifestations, and management

Salivary and Urinary Total Antioxidant Capacity as Biomarkers of Oxidative Stress in Humans

Glutathione and redox signaling in substance abuse

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