Effect of ALDH2 and CYP2E1 Gene Polymorphisms on Drinking Behavior and Alcoholic Liver Disease in Japanese Male Workers

Okamoto, Kinya; Murawaki, Yoshikazu; Yuasa, Isao; Kawasaki, Hironaka

doi:10.1097/00000374-200106001-00006

Cited by 17 publications

(23 citation statements)

References 25 publications

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“…Okamoto et al . found that in the Japanese men, the heterozygous GA genotype of ALDH2 gene carriers had the less capacity for alcohol than the wild homozygous GG genotype, a result that Yu et al . replicated in the Chinese Han population.…”

Section: Discussionmentioning

confidence: 89%

“…Chang et al [23] found that as the key enzyme of alcohol metabolism, ALDH2 gene could influence the individual alcohol consumption and drink frequency. Okamoto et al [24] found that in the Japanese men, the heterozygous GA genotype of ALDH2 gene carriers had the less capacity for alcohol than the wild homozygous GG genotype, a result that Yu et al [25] replicated in the Chinese Han population. The accumulation of acetaldehyde secondary to the reduced ALDH2 enzymatic activity can cause flushing, tachycardia and nausea more rapidly in an individual with the gene polymorphism and effectively restrict alcohol consumption.…”

Section: Discussionmentioning

confidence: 99%

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ALDH2 gene G487A polymorphism and coronary artery disease: a meta‐analysis including 5644 participants

Wang

et al. 2017

J Cellular Molecular Medi

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Several studies indicate the mitochondrial Aldehyde Dehydrogenase‐2 (ALDH2) gene G487A polymorphism may be correlated with coronary artery disease (CAD) susceptibility, but a clear consensus has yet to be reached. To elucidate the relationship between the ALDH2 gene G487A polymorphism and CAD within the Chinese population, a meta‐analysis of 5644 subjects from nine individual studies was performed. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals were assessed using random or fixed‐effect models depending the heterogeneity existence or not. Our meta‐analysis found a significant association between ALDH2 gene G487A polymorphism and CAD in the Chinese population under allele (OR: 1.830, 95% CI: 1.560–2.140, P = 1.36 × 10−13), recessive (OR: 1.920, 95% CI: 1.530–2.390, P = 1.20 × 10−8), dominant (OR: 1.593, 95% CI: 1.336–1.900, P = 2.22 × 10−7), homozygous (OR: 2.280, 95% CI: 1.810–2.870, P = 3.17 × 10−12) and heterozygous genetic models (OR: 3.330, 95% CI: 2.070–5.370, P = 7.81 × 10−7). The positive correlation between the ALDH2 gene G487A polymorphism and CAD makes the mutation a strong candidate as a genetic risk marker for CAD. Through further analysis, we also found that A allele carriers of ALDH2 gene G487A polymorphism may be particularly susceptible to CAD.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

ALDH2 gene G487A polymorphism and coronary artery disease: a meta‐analysis including 5644 participants

Wang

et al. 2017

J Cellular Molecular Medi

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“…Interestingly, another polymorphism in CYP2E1 , Taq I, is associated with reduced susceptibility to ALD, although this allele does not directly affect alcohol metabolism 69 . Several studies from Japan and Korea have searched for associations between the polymorphisms in CYP2E1 and ALD without positive results 70, 71 . A study of Chinese of Han, Mongol, and Chaoxian nationalities found a positive association between the c2 genotype and ALD 72 .…”

Section: Factors Associated With Aldmentioning

confidence: 99%

Alcoholic Liver Disease in Asia, Europe, and North America

2016

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Alcoholic liver diseases (ALD) comprise a spectrum of clinical disorders and changes in liver tissue that can be detected by pathology analysis. These range from steatosis to more severe signs and symptoms of liver disease associated with inflammation, such as those observed in patients with alcoholic hepatitis or cirrhosis. Although the relationship between alcohol consumption and liver disease is well established, severe alcohol-related morbidities develop in only a minority of people who consume alcohol in excess. Inter-individual differences in susceptibility to the toxic effects of alcohol have been extensively studied—they include pattern of alcohol consumption, sex, environmental factors (such as diet), and genetic factors, which vary widely among different parts of the world. ALD is becoming more common in many parts of Asia but is decreasing in Western Europe. Treatment approaches, including availability of medications, models of care, and approach to transplantation, differ among regions.

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“…4,[44][45][46] However, these results have not been confirmed in other investigations. 47,48 Polymorphisms in genes encoding proinflammatory cytokines known to participate in the pathogenesis of ALD have also been examined. A single nucleotide polymorphism (SNP) located in the promoter region of the TNF-␣ gene, which results in increased cytokine production, is associated with more severe steatohepatitis.…”

Section: Gene Polymorphisms Influencing Liver Fibrosis In Humansmentioning

confidence: 99%

Genetic Polymorphisms and the Progression of Liver Fibrosis: A Critical Appraisal

2003

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Liver fibrosis is a highly dynamic process in which multiple genes interact with environmental factors. Recent human epidemiologic studies have identified possible polymorphisms in a number of candidate genes that influence the progression of liver fibrosis. These genetic factors could explain the broad spectrum of responses to the same etiologic agent found in patients with chronic liver diseases. Polymorphisms in genes encoding immunoregulatory proteins, proinflammatory cytokines, and fibrogenic factors may influence disease progression in patients with alcohol-induced liver disease, primary biliary cirrhosis, or chronic hepatitis C. However, some of the studies have yielded contradictory results. For example, conflicting results have been obtained in studies assessing the role of mutations in the hemochromatosis gene on fibrosis progression in patients with chronic hepatitis C. Largescale, well-designed studies are required to clarify the actual role of this factor and other genetic variants in liver fibrosis. (HEPATOLOGY 2003;37:493-503.)

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Effect of ALDH2 and CYP2E1 Gene Polymorphisms on Drinking Behavior and Alcoholic Liver Disease in Japanese Male Workers

Abstract: The ALDH2 genotype is strongly associated with individual alcohol drinking behavior and the development of alcoholic liver disease in Japanese male workers, but the CYP2E1 genotype is not.

Cited by 17 publications

References 25 publications

ALDH2 gene G487A polymorphism and coronary artery disease: a meta‐analysis including 5644 participants

ALDH2 gene G487A polymorphism and coronary artery disease: a meta‐analysis including 5644 participants

Alcoholic Liver Disease in Asia, Europe, and North America

Genetic Polymorphisms and the Progression of Liver Fibrosis: A Critical Appraisal

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