Effect of Aldosterone on Renal Excretion of Intravenously Administered Saline1

Cole, D. F.

doi:10.1210/endo-60-4-562

Cited by 15 publications

(3 citation statements)

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“…The tubular reabsorption of sodium in the mammalian kidney is stimulated after administration of aldosterone (1)(2)(3). The transport of sodium from the tubular lumen to the interstitial compartments, across the cells lining the renal tubule, represents an active process (4,5), and one is therefore led to conclude that this process is influenced by aldosterone.…”

mentioning

confidence: 99%

Stimulation of Active Sodium Transport by the Isolated Toad Bladder With Aldosterone in Vitro*

Crabbé¹

1961

J. Clin. Invest.

238

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confidence: 99%

Stimulation of Active Sodium Transport by the Isolated Toad Bladder With Aldosterone in Vitro*

Crabbé¹

1961

J. Clin. Invest.

238

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“…The active sodium transport target for aldosterone was first demonstrated in amphibian urinary bladder [31]. One of the earliest reports of rapid actions of aldosterone on sodium transport in the kidney was in 1957 when Cole described the rapid effect of aldosterone administration for 30 min to cause a reduction in urinary loss of Na + and increased reabsorption by the renal tubules in response to intravenously administered saline in adult male rats [18]. It has also been documented that aldosterone infusion into aldosterone-suppressed rats (by adrenalectomy or infusion with sodium bicarbonate) resulted in the rapid increase in urinary Na + excretion [19].…”

Section: Non-genomic Actions Of Aldosterone On Ion Transportersmentioning

confidence: 99%

Aldosterone Regulation of Protein Kinase Signaling Pathways and Renal Na⁺Transport by Non-genomic Mechanisms

Thomas¹,

Harvey²

2019

Aldosterone-Mineralocorticoid Receptor - Cell Biology to Translational Medicine

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Aldosterone is the key regulating hormone of whole-body fluid and electrolyte homeostasis. Perturbations in aldosterone synthesis and over-activation of the mineralocorticoid receptor (MR) can lead to excess salt reabsorption and hypertension. The cortical collecting duct (CCD) is the main site of action in the kidney for aldosterone regulation of whole-body sodium homeostasis through actions on the epithelial sodium channel (ENaC) and the Na/K-ATPase (Na/K pump). Aldosterone stimulates ENaC trafficking into the apical cell membranes in the CCD and enhances channel stability and open probability, as well as activating the basolateral membrane Na/K pump to produce an overall increase in the transepithelial reabsorption of sodium. Aldosterone/MR regulates the activity of ENaC in the CCD through both rapid non-genomic (secs-mins) and latent genomic (hours-days) signaling pathways. These rapid and slow responses of renal Na + transport pathways to aldosterone are often treated as distinct and separate events. However, recent evidence points to a close integration between genomic and non-genomic responses to aldosterone to regulate ENaC and Na/K pump activity via protein kinase signaling pathways. Here, we review the integration of aldosterone membrane-initiated non-genomic and nuclear genomic regulations of renal sodium transport via protein kinase signaling pathways and in particular via protein kinase D isoforms.

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“…It has been shown that these changes in the rate of secretion of aldosterone in response to changes in body potassium are independent of sodium concentration in the serum or the total amount of sodium in the body and are also independent of the sodium: potassium ratio in the serum (Bartter, 1956;Bartter et al, 1959). Similarly, there is no evidence to suggest that altered renal hemodynamics are responsible for the altered secretory rates of aldosterone (Bartter et al, 1956;Cole, 1957).…”

Section: Introductionmentioning

confidence: 99%

Physiological Mammalogy

1963

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The first volume consists of two comprehensive articles dealing with the physiology of populations. Calhoun's "The Social Use of Space" presents many interesting new ideas on the behavior of animals in populations and the effects of grouping of individuals upon the physiology of the organism. Where many workers have thought of the experimental animal only as an individual apparently divorced from his environment and other members of the species, Calhoun points out the fallacy of this view in providing experimental data that demonstrate the effects of numbers of individuals on the behavior of each individual. Christian's article on population growth treats the problem largely from an ecological viewpoint in dealing with limiting factors of natural populations and population interrelationships. Volume II will consist of three contributions dealing with natural populations and their adaptations to stressful environments. Dr. Charles Kayser treats the mammalian phenomenon of hibernation as a mechanism for avoiding periods of unfavorable environment, and Dr. Robert Chew deals with water balance in desert rodents. Inasmuch as reproduction is considerably affected by the environment, it too can be considered a process modified by environmental stresses, and is discussed in the second volume. Subsequent volumes will include articles on such topics as temperature and metabolism, physiological genetics, photoperiod, and orientation by echolocation. The Editors will conclude the series with a summary article on the phylogeny of physiology. The Editors feel particularly fortunate in that they have received fine cooperation from outstanding authorities in the specific subject matter topics covered. It is the caliber of the individual author on which these volumes base their contribution to science; and while the Editors assume any responsibility for defects of organization or inadvertent errors, the credit for the success of the volumes, as a whole, rests on the indi^'idual contributors.

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Effect of Aldosterone on Renal Excretion of Intravenously Administered Saline1

Cited by 15 publications

References 0 publications

Stimulation of Active Sodium Transport by the Isolated Toad Bladder With Aldosterone in Vitro*

Stimulation of Active Sodium Transport by the Isolated Toad Bladder With Aldosterone in Vitro*

Aldosterone Regulation of Protein Kinase Signaling Pathways and Renal Na⁺Transport by Non-genomic Mechanisms

Physiological Mammalogy

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Effect of Aldosterone on Renal Excretion of Intravenously Administered Saline1

Cited by 15 publications

References 0 publications

Stimulation of Active Sodium Transport by the Isolated Toad Bladder With Aldosterone in Vitro*

Stimulation of Active Sodium Transport by the Isolated Toad Bladder With Aldosterone in Vitro*

Aldosterone Regulation of Protein Kinase Signaling Pathways and Renal Na+Transport by Non-genomic Mechanisms

Physiological Mammalogy

Contact Info

Product

Resources

About

Aldosterone Regulation of Protein Kinase Signaling Pathways and Renal Na⁺Transport by Non-genomic Mechanisms