Effect of alendronate on the progression of periodontitis induced by Porphyromonas gingivalis and Fusobacterium nucleatum: a study in rats

Storrer, Carmen Lúcia Mueller; Deliberador, Tatiana Miranda; Giovanini, Allan Fernando; Crivellaro, Viviane Rozeira; Zielak, João César; Romito, Giuseppe Alexandre

doi:10.1007/s00784-016-1769-4

Cited by 11 publications

(7 citation statements)

References 39 publications

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“…These results agree with previous studies in which treatment with zoledronate attenuated alveolar bone loss, increased total bone volume and density 16,18 . Additionally, other authors have shown lower alveolar bone loss with other types of bisphosphonates, both locally and systemically applied, in animals 8,39,40 …”

Section: Discussionsupporting

confidence: 92%

Effect of resveratrol on the progression of experimental periodontitis in an ovariectomized rat model of osteoporosis: Morphometric, immune‐enzymatic, and gene expression analysis

Molez

Nascimento

Haiter-Neto

et al. 2020

J of Periodontal Research

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Objective: This study aimed to determine the role of resveratrol (RESV) on the progression of experimental periodontitis (EP) in ovariectomy rats (OVT). Background: Estrogen deficiency is the main cause of osteoporosis and is related to higher periodontal attachment loss and reduction of alveolar bone. Zoledronate (ZLD) is an antiresorptive drug used to control osteoporosis but can lead to osteonecrosis of the jaw. RESV, a natural product, can reduce bone loss and control and prevent osteoporosis. Thus, this study aimed at investigating the effect of RESV on the progression of EP in estrogen-deficient rats. Material and Methods: The animals were subjected to the OVT or sham surgery to induce estrogen-deficiency and then were divided into the groups: OVT + RESV (n: 10);

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Section: Discussionsupporting

confidence: 92%

Effect of resveratrol on the progression of experimental periodontitis in an ovariectomized rat model of osteoporosis: Morphometric, immune‐enzymatic, and gene expression analysis

Molez

Nascimento

Haiter-Neto

et al. 2020

J of Periodontal Research

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“…On the other hand, the oral administration of alendronate to treat osteoporosis has shown to have a 0% to 0.4% chance of inducing ONJ [ 88 ]. Consequently, several studies have investigated the beneficial effects of alendronate administration to manage experimental periodontitis in rats [ 35 , 37 , 89 , 90 ] and PD in clinical trials [ 91 – 93 ]. Some of the described studies are described in table 2 .…”

Section: Bisphosphonatesmentioning

confidence: 99%

Pharmacological Therapies for the Management of Inflammatory Bone Resorption in Periodontal Disease: A Review of Preclinical Studies

Pavanelli

Menezes

Pereira

et al. 2022

BioMed Research International

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Periodontitis, a highly prevalent multicausal chronic inflammatory and destructive disease, develops as a result of complex host-parasite interactions. Dysbiotic bacterial biofilm in contact with the gingival tissues initiates a cascade of inflammatory events, mediated and modulated by the host’s immune response, which is characterized by increased expression of several inflammatory mediators such as cytokines and chemokines in the connective tissue. If periodontal disease (PD) is left untreated, it results in the destruction of the supporting tissues around the teeth, including periodontal ligament, cementum, and alveolar bone, which lead to a wide range of disabilities and poor quality of life, thus imposing significant burdens. This process depends on the differentiation and activity of osteoclasts, the cells responsible for reabsorbing the bone tissue. Therefore, the inhibition of differentiation or activity of these cells is a promising strategy for controlling bone resorption. Several pharmacological drugs that target osteoclasts and inflammatory cells with immunomodulatory and anti-inflammatory effects, such as bisphosphonates, anti-RANK-L antibody, strontium ranelate, cathepsin inhibitors, curcumin, flavonoids, specialized proresolving mediators, and probiotics, were already described to manage inflammatory bone resorption during experimental PD progression in preclinical studies. Meantime, a growing number of studies have described the beneficial effects of herbal products in inhibiting bone resorption in experimental PD. Therefore, this review summarizes the role of several pharmacological drugs used for PD prevention and treatment and highlights the targeted action of all those drugs with antiresorptive properties. In addition, our review provides a timely and critical appraisal for the scientific rationale use of the antiresorptive and immunomodulatory medications in preclinical studies, which will help to understand the basis for its clinical application.

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“…However, to induce the same lesion, this method may need a longer time (8,9). A combination of ligature and inoculation of P. gingivalis has been reported to induce alveolar bone loss in the rat model (10). The combination of ligature with a pathogenic product, such as lipopolysaccharide from P. gingivalis, which would accelerate the process, is not well described.…”

Section: Introductionmentioning

confidence: 99%

Development of experimentally-induced periodontitis in a Sprague Dawley rat model

Mustafa¹,

Ali²,

Chen³

et al. 2021

IJVS

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Periodontitis is a common inflammatory disease that leads to the degradation of periodontium and results in alveolar bone loss. The development of a suitable animal model of periodontitis is a prerequisite to understanding better the mechanisms that underly this disease. This study evaluated periodontal disease induction via retentive ligature, intragingival injection of lipopolysaccharide (LPS), and their combination in a rat model. Seventy-two Sprague Dawley rats were divided into four groups. The first group (control) did not receive any treatment. The second group underwent the application of 4/0 nylon ligature around the second maxillary molars. The third group was treated with an intragingival injection of Porphyromonas gingivalis LPS into the palatal mucosa of the second maxilla molars, and the fourth group was treated with a combination of ligature and LPS injection (ligature-LPS). Morphological changes in the gingival tissues were evaluated after 7, 14, and 30 days of treatment. Significant degenerative changes were observed in the periodontal tissues and alveolar bone in the third and fourth groups, which were evident as early as seven days. The lesions remained until 14 days and declined with time in the third and fourth groups. The changes induced by ligature and ligature-LPS were not different. Injection with LPS alone resulted in minimal increases in the Gingival and Plaque Indices. The ligature technique induced periodontal disease successfully, more effective than the injection of LPS. The combination of ligature with LPS injection added no significant effect compared to ligature alone.

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Effect of alendronate on the progression of periodontitis induced by Porphyromonas gingivalis and Fusobacterium nucleatum: a study in rats

Abstract: ALN could be a potential therapeutic approach when associated with periodontal treatment.

Cited by 11 publications

References 39 publications

Effect of resveratrol on the progression of experimental periodontitis in an ovariectomized rat model of osteoporosis: Morphometric, immune‐enzymatic, and gene expression analysis

Effect of resveratrol on the progression of experimental periodontitis in an ovariectomized rat model of osteoporosis: Morphometric, immune‐enzymatic, and gene expression analysis

Pharmacological Therapies for the Management of Inflammatory Bone Resorption in Periodontal Disease: A Review of Preclinical Studies

Development of experimentally-induced periodontitis in a Sprague Dawley rat model

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