Effect of Aliphatic Oxime and Isatin Thiosemicarbazones on Vaccinia Infection in the Mouse and in the Rabbit

Thompson, Randall L.; Davis, Jeanette; Russell, Peter B.; Hitchings, George H.

doi:10.3181/00379727-84-20690

Cited by 57 publications

(23 citation statements)

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“…Different derivatives of MI-TSC also possess significant anticancer activity [22]. It was also found that isatin-based thiosemicarbazones protect mice against intracerebral vaccinia virus while isatin-based semicarbazones were inactive [23]. Bain et al [24] reported the synthesis and spectroscopic investigations of N4 -substituted isatin thiosemicarbazones and their copper(II) complexes.…”

Section: Introductionmentioning

confidence: 99%

A theoretical investigation on the isomerism and the NMR properties of thiosemicarbazones

Silva

Albu

2007

Open Chemistry

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Hybrid density functional theory calculations at the mPW1PW91/6-31+G(d,p) level of theory have been used to investigate the optimized structures and other molecular properties of five different series of thiosemicarbazones. The investigated compounds were obtained from acenaphthenequinone, isatin and its derivatives, and alloxan. The focus of the study is the isomerism and the NMR characterization of these thiosemicarbazones. It was found that only one isomer is expected for thiosemicarbazones and methylthiosemicarbazones, while for dimethylthiosemicarbazones, two isomers are possible. All investigated thiosemicarbazones exhibit a hydrazinic proton that is highly deshielded and resonates far downfield in the proton NMR spectra. This proton is a part of a characteristic sixmembered ring, and its NMR properties are a result of its strong, intermolecular hydrogen bond. The relationships between the calculated 1 H and 13 C NMR chemical shifts and various geometric parameters are reported.

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Section: Introductionmentioning

confidence: 99%

A theoretical investigation on the isomerism and the NMR properties of thiosemicarbazones

Silva

Albu

2007

Open Chemistry

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“…H). It was the discovery that heterocyclic TSCs could possess antiviral activity (THOMPSON et al 1953b). Compounds containing pyridine (Fig.…”

Section: Quinoline Pyridine and Thiophene Thiosemicarbazonesmentioning

confidence: 99%

“…No other viruses but the poxviruses have been reported to contain copper (HOAGLAND et al 1941;JOK-UK 1962;ZWARTOUW 1964) and this may be what sets them apart in their in vivo sensitivity to the IBTs. THOMPSON et al (1953 a) were aware that thiosemicarbazones were chelating agents and they attempted to determine, not if metals would enhance the antipox activity of these compounds, but rather if they would inhibit their activity in mice. A number of substances, including monovalent cuprous chloride, were found to have no influence on the activity of various thiosemicarbazones.…”

Section: Cj Pfaumentioning

confidence: 99%

The Thiosemicarbazones

Pfau¹

1982

Chemotherapy of Viral Infections

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“…The cocrystallization of Ce 2 (SO 4 ) 3 and La 2 (SO 4 ) 3 in aqueous and H 2 SO 4 (150 g/dm 3 ) solutions at 25°C and 64°C is studied [16]. Thiosemicarbazones have received more attention as they possess a wide spectrum of medicinal properties [17]- [21] including activity against bacterial, tuberculosis, leprosy , viral infections, psoriasis, rheumatism, trypanosomiasis, coccidiosis and malaria. In most of the complexes studied, thiosemicarbazone function coordinates to the metal ion in the cis configuration as a bidentate ligand bonding through thione/thiol sulphur atom and the imino nitrogen atom in a bidentate manner, resulting in the formation of a five membered chelate ring.…”

Section: Introductionmentioning

confidence: 99%

Cyclic Voltammetric Studies on Metal-organic Complexes Containing Piperidin-4-one Thiosemicarbazones

Selvaraj

Sujatha²

2014

ScieXplore: International Journal of Research in Science

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Six cerium(III) nitrate complexes with variously substituted 2,6-diphenylpiperidin-4-one thiosemicarbazones have been prepared and characterized by elemental analyses, molecular weight determinations, molar conductance, IR, magnetic, cyclic voltammetric and thermal studies. Generally, cerium(III) may be easily converted to cerium(IV). In order to ascertain the oxidation state of the cerium in the prepared complexes, the cyclic voltammetric studies have been carried out. It has been observed that increase of potential produces an anodic peak in both the complexes. This indicates that the complexes are getting oxidized which consequently means that they were in the reduced form initially. Thus it is confirmed that cerium is present in +3 oxidation state in its complexes. This is further supported by the studies on concentration effect and sweep rate. Based on the above observations, 10-coordinated structure has been proposed for the complexes.

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Effect of Aliphatic Oxime and Isatin Thiosemicarbazones on Vaccinia Infection in the Mouse and in the Rabbit

Cited by 57 publications

References 0 publications

A theoretical investigation on the isomerism and the NMR properties of thiosemicarbazones

A theoretical investigation on the isomerism and the NMR properties of thiosemicarbazones

The Thiosemicarbazones

Cyclic Voltammetric Studies on Metal-organic Complexes Containing Piperidin-4-one Thiosemicarbazones

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