Effect of allopurinol, sulphasalazine, and vitamin C on aspirin induced gastroduodenal injury in human volunteers.

McAlindon, ME; Muller, A F; Filipowicz, B; Hawkey, Chris J.

doi:10.1136/gut.38.4.518

Cited by 27 publications

(29 citation statements)

References 48 publications

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“…Allopurinol was chosen for its antioxidant properties, 12,13 able to heal duodenal ulcer. 6 To avoid any bias in the allocation of patients either to the AB or the AO group, the randomization plan was based on a blocking randomization procedure.…”

mentioning

confidence: 99%

Helicobacter pylori eradication and l-dopa absorption in patients with PD and motor fluctuations

Pierantozzi¹,

Pietroiusti²,

Brusa³

et al. 2006

Neurology

175

152

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mentioning

confidence: 99%

Helicobacter pylori eradication and l-dopa absorption in patients with PD and motor fluctuations

Pierantozzi¹,

Pietroiusti²,

Brusa³

et al. 2006

Neurology

175

152

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“…31,32 The concentration of cholesterol, another important membrane constituent of eukaryotic cells, also showed significantly similar dose-dependent decline in IEC and IEC-6, suggesting an altered fluidity of membrane with higher dose exposures in these two types of cells. However, there was no significant change in phospholipid content of IEC, IEC-6 and the bacterial cell membrane.…”

Section: Discussionmentioning

confidence: 84%

Experimental impact of aspirin exposure on rat intestinal bacteria, epithelial cells and cell line

2010

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Aspirin, a commonly used therapeutic non-steroidal anti-inflammatory drug (NSAID) is known to cause gastric mucosal damage. Intestinal bacteria having a regulatory effect on intestinal homeostasis play significant role in NSAID-induced intestinal injury. Bacteria and specific cell lines are considered to be suitable for toxicity screening and testing of chemicals. Therefore, to evaluate and compare in vitro toxicity, cultures of rat intestinal epithelial cells (IEC), isolated bacteria and IEC-6 cell line were assessed for viability, morphometric analysis, membrane transport enzymes and structural constituents for membrane damage, dehydrogenase activity test for respiratory and energy producing processes and esterase activity test for intra- and extra-cellular degradation, following the post exposure to aspirin (0—50 µg mL- 1). Similar pattern of dose-dependent changes in these parameters were observed in three types of cells. Similar in situ effects on IEC validated the in vitro findings. These findings indicate that higher aspirin concentrations may alter cellular functions of IEC and gut bacteria. Furthermore, results suggest that gut bacteria and IEC-6 cell line can be used for the initial screening of gastrointestinal cellular toxicity caused by NSAIDs.

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“…Aspirin induces the reactive oxygen metabolites in animal models, which may contribute to mucosal injury (21). The role of these reactive oxygen species and the potential antioxidant protective effect of (SBE) on gastric mucosal tissue are topic of high current interest.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant effect of methanolic extract ofSolanum nigrum berries on aspirin induced gastric mucosal injury

Jainu

Devi

2004

Indian J Clin Biochem

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The antiulcerogenic effects of the methanolic extract of Solanum nigrum berries (SBE) on aspirin induced ulceration in rats with respect to antioxidant status in the gastric mucosa have been investigated. Oxygen free radicals are considered to be important factors in the pathogenesis of gastric ulcer. The level of lipid peroxides, which were elevated highly in rats with acute gastric mucosal injury was taken as an index of oxidative stress .The activities of antioxidant defense enzymes were also decreased considerably by oral gastric adminisb'alJon of aspirin. The decreased levels of antioxidant enzymes and increased mucosal injury were altered to near normal status upon pretreatment with (SBE) when compared to the ulcer induced rats. The results indicate that (SBE) may exert its gastroprotective effect by a free radical scavenging action. Our observations suggest that (SBE) may have considerable therapeutic potential in the treabnent of gastric diseases.

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Effect of allopurinol, sulphasalazine, and vitamin C on aspirin induced gastroduodenal injury in human volunteers.

Cited by 27 publications

References 48 publications

Helicobacter pylori eradication and l-dopa absorption in patients with PD and motor fluctuations

Helicobacter pylori eradication and l-dopa absorption in patients with PD and motor fluctuations

Experimental impact of aspirin exposure on rat intestinal bacteria, epithelial cells and cell line

Antioxidant effect of methanolic extract ofSolanum nigrum berries on aspirin induced gastric mucosal injury

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