Effect of Alloxan Administration on Liver Nucleoproteins.

Diermeier, H. F.; Stefano, Henry S. Di; Tepperman, Jay; Bass, Allan D.

doi:10.3181/00379727-77-18922

Cited by 4 publications

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“…The effect of a diabetogenic dose of alloxan is shown in Table 2, section 3. The values of 't' found for each of the three methods of estimation do not indicate a significant change in the average DNAP content of the liver nuclei although Diermeier et al (1951) reported that, in the rat, alloxan caused a 12 % increase in the DNA content of round liver nuclei of about 7 IL. diameter.…”

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The deoxyribonucleic acid content of the rat cell nucleus and its use in expressing the results of tissue analysis, with particular reference to the composition of liver tissue

Thomson

Heagy

Hutchison

et al. 1953

Biochemical Journal

263

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I953 activity of diphosphopyridinenucleotidase is greatly increased (Nason et al. 1951)-there is no reason to attribute invariably the disorders of metabolism which occur in zinc deficiency to a primary impairment of protein synthesis. Copper deficiency has been claimed to have marked effects on the protein metabolism of green plants (Gilbert, Sell & Drosdoff, 1946; Wood & Womersley, 1946; Lucas, 1948; Gilbert, 1951), and so the observation that the aldolase activity in the leaves of copper-deficient oats remains unimpaired, suggests that the lowered aldolase activity in the leaves of zinc-deficient oats is not due primarily to a decreased protein synthesis; although zinc might be specifically involved in the synthesis of the enzyme itself. The third possibility that the aldolases of green leaves are activated by Zn2+ or by zinc-containing co-enzymes is being examined. SUMMARY Aldolase activity was found to be materially decreased in tissue suspensions prepared from the leaves of zinc-deficient plants of Trifolium subterrane,um and of Avena 8ativa, but was unchanged by copper deficiency. The author is grateful to K. Powrie for supplying some of the experimental material: to G. B. Jones for the polarographic estimation of zinc and copper and to V. Stephen who set up the aeration apparatus and is particularly indebted to H. R. Marston, F.R.S., Chief of the Division of Biochemistry and General Nutrition, C.S.I.R.O., for his advice and criticism during the experiment and his help in preparation of the manuscript. Glasshouse accommodation was made available by Prof. J. G. Wood of the Botany Department of the University of Adelaide, and this courtesy is gratefully acknowledged.

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“…Some animals were subjected to the procedure ofpartial hepatectomy (removalofmedian andleft lateral lobes), by the method of Higgins & Anderson (1931). Others received alloxan as described by Diermeier, Di Stephano, Tepperman & Bass (1951). Such animals were fasted for 48 hr.…”

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confidence: 99%

The deoxyribonucleic acid content of the rat cell nucleus and its use in expressing the results of tissue analysis, with particular reference to the composition of liver tissue

Thomson

Heagy

Hutchison

et al. 1953

Biochemical Journal

263

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“…In addition to the factors postulated above it is known that a morphological increase in size may be due to compensatory hypertrophy following such operations as unilateral nephrectomy (Sulkin, 1949) or partial hepatectomy (Sulkin, 1943), to hormonal agents like oestrone (Salvatore. 1950;Alfert and Bern, 1951;Schreiber, 1954), or to agents which stimulate chromosomal activity such as thiouracil (Roels, 1954), alloxan (Diermeier et al, 1951) and colchicine (Bucher, 1951;Fankhauser, 1952).…”

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Nuclear Sizes in Rana Mesonephroi

Connell

1959

The Biological Bulletin

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When Jacobj (1925) devised the now classical caryometric method there was opened up for the cytologist a whole new field in population dynamics. Jacobj demonstrated that for any given organ the nuclear population showed considerable variation in size from one individual nucleus to another. By plotting frequency distribution curves of nuclear volumes he obtained evidence to show that the volumes increased discontinuously according to a logical pattern. The peaks of the curve corresponded to nuclear volumes which when arranged in series gave the geometric progression 1 : 2 : 4 : 8. Nuclear class series have since been described for a wide range of both invertebrate and vertebrate tissues.Caryometry has been used extensively in investigations of ploidy, of endomitotic growth, and of the interphasic growth of nuclei in a dividing tissue. The concept

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The Metabolic Stability of Nuclear DNA

Adrian¹

1971

Cellular and Molecular Renewal in the Mammalian Body

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Effect of Alloxan Administration on Liver Nucleoproteins.

Cited by 4 publications

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The deoxyribonucleic acid content of the rat cell nucleus and its use in expressing the results of tissue analysis, with particular reference to the composition of liver tissue

The deoxyribonucleic acid content of the rat cell nucleus and its use in expressing the results of tissue analysis, with particular reference to the composition of liver tissue

Nuclear Sizes in Rana Mesonephroi

The Metabolic Stability of Nuclear DNA

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