Effect of alpha-fetoprotein on lifespan of old mice

Abstract

Alpha-fetoprotein (AFP) is one of the best-known embryo-specific proteins. It is used to diagnose fetal abnormalities and tumors of the gastrointestinal tract and liver. AFP has pronounced immunotropic and detoxifying effect and a direct apoptotic effect on tumor cells. The treatment of mice at the oldest age in our experiments with AFP dramatically increased the survival and markedly increased the relative weight of immunotropic organs, apparently due to the general effect of AFP in improving functions of tissues and detoxifying actions. It also improved appearance and the relative weight of internal organs with a reduced age of autoaggression.

Natural aging as as a sequential poly-systemic syndrome

“…However, animal trials have shown a characteristic effect of several popular pharmacological agents, demonstrating an increase in longevity, i.e. the inhibition of aging or "geroprotective effect" (5,11,12,19,21). This effect is shown, in particular, for aspirin (51,52), metformin (53), rapamycin (54), and some other drugs (11,12,19).…”

“…together with reduced working capacity, adaptation ability, physical strength, and intellectual capacity. Moreover, to date a significant amount of experimental data on "anti-aging drugs" (or "geroprotectors") has accumulated (6,(11)(12)(19)(20)(21). A new field of practical medicine, so-called "anti-aging medicine", is rapidly developing.…”

“…The objective of this article is to review the close relationship and even identity between the main natural aging syndromes and the typical syndromes of common diseases, as well as to show a possibility to affect the process of natural aging with modern medical means. This approach legitimizes research and practical application in medical practice of the so-called "geroprotectors" -a special class of pharmacological agents and other therapeutic methods, with the main intended effect being increasing healthy longevity (6,11,12,19,21).…”

"Lymphocyte Regulation of Cellular Growth of Somatic Tissues: A New Look at the Origin of the Immune System and New Immune Theory of Aging (History and Modern Concepts)"

“…Thus, the function of T-lymphocytes is suggested decrease sharply during aging due to changes in the organism's regulatory systems. We have discovered a variety of experimental evidence and have shown that it is possible to reactivate and rapidly regenerate the growth potential of somatic cells under the influence of the imminity [31,32].Thus, the proposed new immune-age theory is not only of theoretical interest but also makes it possible to use the whole potential of immunopharmacology to counteract one of the crucial mechanisms of aging: the age-related decrease in cell selfrenewal in the multicellular organisms, including mammals and humans.…”

A New Look At the Origin of the Immune System and New Immune Theory of Aging: Lymphocyte Regulation of Cellular Growth of Somatic Tissues: (History and Modern Concepts)

“…We have discovered a variety of experimental evidence and have shown that it is possible to reactivate and rapidly regenerate the growth potential of somatic cells under the influence of the immunity and to reverse the symptoms of aging in the experiment [32,33]. Thus, the proposed new immune-age theory is not only of theoretical interest but also makes it possible to use the whole potential of immuno-pharmacology to counteract one of the crucial mechanisms of aging: the age-related decrease in cell self-renewal in the multi-cellular organisms, including mammals and humans.…”