Effect of alpha-glucosidehydrolase inhibition and intestinal absorption of sucrose, water, and sodium in man.

Abstract

SUMMARY The effect of a new complex oligosaccharide exhibiting potent inhibitory action on ax-glucoside hydrolases on intestinal absorption of sucrose in man was tested by constant in vivo perfusion of the jejunum. At concentrations of 4-65 or 155 x 10-6M the ac-glucosidehydrolase inhibitor (a-GHI) markedly inhibited absorption of glucose from sucrose and absorption of sodium and water. Oral administration of the a-GHI resulted as well in depression of solute, sodium, and water absorption. This new compound can serve as an interesting tool to induce carbohydrate malabsorption by inhibition of final digestion and may possibly be of beneficial therapeutic effect in dietary control of diabetes or obesity.

Effects of Acarbose on Serum Lipoproteins in Healthy Individuals during Prolonged Administration of a Fiber-Free Formula Diet

“…This effect could be related to an increase in total fecal bile acid excretion by about 70% [unpublished data]. It is conceiv able that bile acid absorption was affected by a net secretion of water and electrolytes in the small intestine which occurs in highly efficient disaccharidase inhibition [23]. Cho lesterol absorption also could have been di minished; but since acarbose was less effec tive in lowering serum cholesterol in the present experiment than in the initial study despite a lower intake of dietary cholesterol, it is likely that the observed changes of bile acid output were more important than a pos sible decrease of cholesterol absorption.…”

Efficacy and Safety of Miglitol- or Repaglinide-Based Combination Therapy with Alogliptin for Drug-Naïve Patients with Type 2 Diabetes: An Open-Label, Single-Center, Parallel, Randomized Controlled Pilot Study

“…Acarbose, an alpha-glucosidase inhibitor (αGI), improved postprandial hyperglycemia and reduced CAD incidence in patients with impaired glucose tolerance 12 and type 2 diabetes 13 . Among the oral antidiabetics, αGIs and glinides directly suppress postprandial plasma glucose (PG) levels by delaying intestinal absorption of glucose 14 and producing immediate insulin secretion 15 , respectively. We and other researchers reported that incretin-related drugs such as glucagon-like peptide-1 (GLP-1) receptor agonists 16 and dipeptidyl peptidase-4 (DPP-4) inhibitors 17,18 also improve postprandial hyperglycemia.…”

Η Χρηση Ενος Αναστολεα Των Α-Γλυκοσιδασων (Ακαρβοζη) Στην Θεραπεια Των Ινσουλινοεξαρτωμενων Διαβητικων Ασθενων

“…Αυτός ο μηχανι σμός ο οποίος φαίνεται να λειτουργεί μόνον όταν χορη γείται πλήρες γεύμα, είναι δυνατόν.να αποτελεί έναν επιπλέον τρόπο, εκτός από την αναστολή των εντερικών δισακχαριδασών μ ε TC v οποίον η Ακαρβόζη επιμηκύνει έμμεσα την απορρόφηση των υδατανθράκων. (Caspary, 1978, Jenkins et al 1981, Caspary et al 1982.…”