Effect of alpha-lipoic acid on oxidative stress parameters: A systematic review and meta-analysis

Zonooz, Sanaz Rezaei; Hasani, Motahareh; Morvaridzadeh, Mojgan; Pizarro, Ana Beatriz; Heydari, Hafez; Yosaee, Somaye; Rezamand, Gholamreza; Heshmati, Javad

doi:10.1016/j.jff.2021.104774

Cited by 24 publications

(14 citation statements)

References 53 publications

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“…α-LA also acts as a cofactor of pyruvate dehydrogenase (PDH), α-ketoglutarate dehydrogenase (KDH), branched-chain ketoacid dehydrogenase and H-protein of the glycine cleavage system (GCS) [ 27 , 63 , 64 ]. In addition, several studies have shown that α-LA also has a chelating effect on metals like iron or copper reducing iron accumulation in the cerebral cortex and a positive impact on oxidative stress [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

“…Our results indicated that α-LA attenuates these physiopathological alterations in responsive PKAN fibroblasts with residual PANK2 expression levels. Clinical trials support that α-LA administration reduces malondialdehyde (MDA) in serum, a biomarker of lipid peroxidation [ 65 ] and it can also decrease the alcohol-induced lipid peroxidation and protein oxidation [ 77 ].…”

Section: Discussionmentioning

confidence: 99%

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Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels

Talaverón-Rey

Álvarez-Córdoba

Villalón-García

et al. 2023

Orphanet J Rare Dis

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Background Neurodegeneration with brain iron accumulation (NBIA) disorders are a group of neurodegenerative diseases that have in common the accumulation of iron in the basal nuclei of the brain which are essential components of the extrapyramidal system. Frequent symptoms are progressive spasticity, dystonia, muscle rigidity, neuropsychiatric symptoms, and retinal degeneration or optic nerve atrophy. One of the most prevalent subtypes of NBIA is Pantothenate kinase-associated neurodegeneration (PKAN). It is caused by pathogenic variants in the gene of pantothenate kinase 2 (PANK2) which encodes the enzyme responsible for the first reaction on the coenzyme A (CoA) biosynthesis pathway. Thus, deficient PANK2 activity induces CoA deficiency as well as low expression levels of 4′-phosphopantetheinyl proteins which are essential for mitochondrial metabolism. Methods This study is aimed at evaluating the role of alpha-lipoic acid (α-LA) in reversing the pathological alterations in fibroblasts and induced neurons derived from PKAN patients. Iron accumulation, lipid peroxidation, transcript and protein expression levels of PANK2, mitochondrial ACP (mtACP), 4′′-phosphopantetheinyl and lipoylated proteins, as well as pyruvate dehydrogenase (PDH) and Complex I activity were examined. Results Treatment with α-LA was able to correct all pathological alterations in responsive mutant fibroblasts with residual PANK2 enzyme expression. However, α-LA had no effect on mutant fibroblasts with truncated/incomplete protein expression. The positive effect of α-LA in particular pathogenic variants was also confirmed in induced neurons derived from mutant fibroblasts. Conclusions Our results suggest that α-LA treatment can increase the expression levels of PANK2 and reverse the mutant phenotype in PANK2 responsive pathogenic variants. The existence of residual enzyme expression in some affected individuals raises the possibility of treatment using high dose of α-LA.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels

Talaverón-Rey

Álvarez-Córdoba

Villalón-García

et al. 2023

Orphanet J Rare Dis

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“…Additionally, it also helps in reversing the NMDA receptor hypofunction (Stoll et al 1993 ; Tang and Aizenman 1993 ). ALA is an antioxidant, inhibits formation or scavenges free radicals and lipid peroxidation products and enhances neurotrophic factors (Packer et al 1995 ; Rezaei Zonooz et al 2021 ). Oxidative stress and NMDA receptor hypofunction is known to give rise to negative symptoms and cognitive impairment predominantly and positive symptoms to a certain extent in TRS.…”

Section: Discussionmentioning

confidence: 99%

Effect of add-on alpha lipoic acid on psychopathology in patients with treatment-resistant schizophrenia: a pilot randomized double-blind placebo-controlled trial

et al. 2022

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Rationale Alpha lipoic acid is known to reverse NMDA receptor hypofunction in addition to dopamine receptor blockade activity. It also enhances neurotrophic factors and has antioxidant potential. These properties combined together may be beneficial for treatment-resistant schizophrenia (TRS). Objectives This study evaluates the effect of alpha lipoic acid (ALA) on psychopathological scores (positive, negative, cognitive), neurotrophic factors and oxidative stress in TRS. Methods A pilot randomized double-blind placebo-controlled parallel design trial was conducted in 20 patients with TRS. After initial screening, participants were randomized into test (add-on ALA) and control (add-on placebo) groups. After recruitment, clinical evaluations with scale for assessment of positive symptoms and negative symptoms (SAPS and SANS), schizophrenia cognitive rating scale (SCoRS), UKU side effect rating scale were done. Serum levels of BDNF, MDA, and GSH were estimated. Patients were followed up for 8 weeks, and clinical and biochemical evaluations were repeated. Adherence to medication was evaluated at follow-up. Results A significantly greater improvement was found in SANS score in the test group when compared to control (Mann–Whitney U = 17.0; p = 0.021), whereas there was no significant improvement in SAPS score (Mann–Whitney U = 41.5; p = 0.780). A significant increase in BDNF levels was observed in the control group when compared to ALA ( U = 20.0; p = 0.041). No significant differences were found between the test and control groups in serum MDA ( U = 30.0; p = 0.221), serum GSH ( U = 40.0; p = 0.683), and medication adherence rating scale (MARS) scores ( U = 44.0; p = 0.934). Conclusions ALA supplementation improved psychopathology and decreased oxidative stress in patients with TRS. This study thus shows the potential of adjunctive ALA in TRS. Trial registration The study was prospectively registered in Clinical Trial Registry of India (CTRI/2020/03/023707 dated 02.03.2020).

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“…HeLa cells were also treated with monensin for 6 h, followed by PSeZ-Cou-Golgi and an antioxidant lipoic acid (LA) (0.2 mM) for 0–60 min. LA could serve as a ROS scavenger and may change the cell’s internal environment from an oxidized state to a reduced state. , After the treatment, the originally observed red fluorescence signal was restored, while the green fluorescence signal was remarkably weakened. The above results indicate that PSeZ-Cou-Golgi can function as a versatile probe that can monitor the redox state of the Golgi apparatus during both oxidative stress and the repair process.…”

Section: Resultsmentioning

confidence: 97%

Construction of a Dual-Functional, Reversible, Ratiometric, Golgi-Targeting Fluorescent Probe for Real-time Monitoring of Dynamics of Intracellular Redox Homeostasis

Han

Wang

et al. 2023

Anal. Chem.

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Intracellular redox homeostasis is highly important for the physiological processes of living organisms. Real-time monitoring of the dynamics of this intracellular redox process is pivotal but challenging because the biological redox reactions involved in the process are reversible and require at least one pair of oxidizing and reducing species. Thus, biosensors for investigating intracellular redox homeostasis need to be dual-functional, reversible, and, ideally, ratiometric in order for them to have real-time monitoring capacity and to provide accurate imaging information. In light of the importance of the redox pair between ClO– and GSH in living organisms, herein, we used the phenoselenazine (PSeZ) moiety as an electron donor and a reaction site to design a coumarin-based fluorescent probe, PSeZ-Cou-Golgi. After successive treatment with ClO– and GSH, the probe PSeZ-Cou-Golgi experienced an oxidation of selenium (Se) to selenoxide (SeO) by ClO– and a subsequent reduction of SeO to Se by GSH. The redox reactions alternatively changed the electron-donating strength of the donor in the probe PSeZ-Cou-Golgi, in turn affecting the intramolecular charge transfer process that resulted in the reversible, ratiometric change of fluorescence from red to green. After four cycles of reversible ClO–/GSH detection during in vitro experiments, the probe PSeZ-Cou-Golgi still had good performance. With the Golgi-targeting group, the probe PSeZ-Cou-Golgi was able to monitor the dynamic change of the ClO–/GSH-mediated redox state during Golgi oxidative stress, making it a versatile molecular tool. More importantly, the probe PSeZ-Cou-Golgi could facilitate the imaging of the dynamic redox state during acute lung injury progression.

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Effect of alpha-lipoic acid on oxidative stress parameters: A systematic review and meta-analysis

Cited by 24 publications

References 53 publications

Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels

Alpha-lipoic acid supplementation corrects pathological alterations in cellular models of pantothenate kinase-associated neurodegeneration with residual PANK2 expression levels

Effect of add-on alpha lipoic acid on psychopathology in patients with treatment-resistant schizophrenia: a pilot randomized double-blind placebo-controlled trial

Construction of a Dual-Functional, Reversible, Ratiometric, Golgi-Targeting Fluorescent Probe for Real-time Monitoring of Dynamics of Intracellular Redox Homeostasis

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