Effect of altered innervation and thyroid hormones on myosin heavy chain expression and fiber type transitions: a mini-review

Soukup, Tomáš; Smerdu, Vika

doi:10.1007/s00418-014-1276-0

Cited by 19 publications

(20 citation statements)

References 76 publications

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“…Thus, the type IIb fiber identified in our histochemical analysis also included type IIx fibers. In recent reports, it has been suggested that type IIx fibers might be most sensitive to external effects, such as thyroid hormone status (Kopecka et al 2014, Soukup andSmerdu 2015). Thus, glucocorticoids may have different effects on type IIx and IIb muscle fibers.…”

Section: Discussionmentioning

confidence: 99%

Heat Treatment Inhibits Skeletal Muscle Atrophy of Glucocorticoid-Induced Myopathy in Rats

Morimoto

Kondo²,

Kataoka³

et al. 2015

Physiol Res

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The purpose of this study was to investigate the influence of heat treatment on glucocorticoid (GC)-induced myopathy. Eight-week-old Wistar rats were randomly assigned to the control, Dex, and Dex + Heat groups. Dexamethasone (2 mg/kg) was injected subcutaneously 6 days per week for 2 weeks in the Dex and Dex + Heat group. In the Dex + Heat group, heat treatment was performed by immersing hindlimbs in water at 42 °C for 60 min, once every 3 days for 2 weeks. The extensor digitorum longus muscle was extracted following 2 weeks of experimentation. In the Dex + Heat group, muscle fiber diameter, capillary/muscle fiber ratio, and level of heat shock protein 72 were significantly higher and atrogene expression levels were significantly lower than in the Dex group. Our results suggest that heat treatment inhibits the development of GC-induced myopathy by decreasing atrogene expression and increasing angiogenesis.

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Section: Discussionmentioning

confidence: 99%

Heat Treatment Inhibits Skeletal Muscle Atrophy of Glucocorticoid-Induced Myopathy in Rats

Morimoto

Kondo²,

Kataoka³

et al. 2015

Physiol Res

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“…D2 mRNA levels were largely in line with the enzymatic activities, whereas D3 transcript levels were close to the detection limit and therefore did not reveal any significant alterations. Expression of Hairless , a gene positively regulated by TH, was strongly increased in Mct8 KO and M/O DKO mice ( Di Cosmo et al., 2013 ), while mRNA expression of MhcI , which is negatively regulated by TH ( Soukup and Smerdu, 2015 ), was suppressed in Mct8 -deficient mice. Likewise, transcript levels of MhcIIa , MhcIIb , and MhcIIx , known to be stimulated by TH ( Soukup and Smerdu, 2015 ), tended to be elevated in Mct8 KO and M/O DKO mice.…”

Section: Resultsmentioning

confidence: 99%

“…Expression of Hairless , a gene positively regulated by TH, was strongly increased in Mct8 KO and M/O DKO mice ( Di Cosmo et al., 2013 ), while mRNA expression of MhcI , which is negatively regulated by TH ( Soukup and Smerdu, 2015 ), was suppressed in Mct8 -deficient mice. Likewise, transcript levels of MhcIIa , MhcIIb , and MhcIIx , known to be stimulated by TH ( Soukup and Smerdu, 2015 ), tended to be elevated in Mct8 KO and M/O DKO mice. Together, these results are indicative of a hyperthyroid state of skeletal muscle in the absence of MCT8, and MCT8 and OATP1C1.…”

Section: Resultsmentioning

confidence: 99%

“…Skeletal muscle is a well-established TH target tissue as TH regulates the expression of numerous muscle proteins critical for proper muscle development and contractility ( Ambrosio et al., 2017 , Milanesi et al., 2016 , Milanesi et al., 2017 , Soukup and Smerdu, 2015 ). Thus, highly elevated serum T3 levels, as detected in AHDS patients, are expected to heavily affect skeletal muscle homeostasis and regeneration.…”

Section: Discussionmentioning

confidence: 99%

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Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration

et al. 2018

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SummaryThyroid hormone (TH) transporters are required for the transmembrane passage of TH in target cells. In humans, inactivating mutations in the TH transporter MCT8 cause the Allan-Herndon-Dudley syndrome, characterized by severe neuromuscular symptoms and an abnormal TH serum profile, which is fully replicated in Mct8 knockout mice and Mct8/Oatp1c1 double-knockout (M/O DKO) mice. Analysis of tissue TH content and expression of TH-regulated genes indicate a thyrotoxic state in Mct8-deficient skeletal muscles. Both TH transporters are upregulated in activated satellite cells (SCs). In M/O DKO mice, we observed a strongly reduced number of differentiated SCs, suggesting an impaired stem cell function. Moreover, M/O DKO mice and mice lacking both transporters exclusively in SCs showed impaired skeletal muscle regeneration. Our data provide solid evidence for a unique gate-keeper function of MCT8 and OATP1C1 in SC activation, underscoring the importance of a finely tuned TH signaling during myogenesis.

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“…The muscle's adaptive capacity is assumed to be related to its original and genetically determined fiber type composition, appropriate to the muscle's functional role and may be also species-specific (Blaauw et al 2013). However, it can be secondarily modulated by various extrinsic factors such as the type of innervation or electrical stimulation, muscle loading or activity level, and hormonal factors, especially thyroid hormones (Pette and Staron 1997, Baldwin and Haddad 2002, Schiaffino and Reggiani 2011, Soukup and Smerdu 2015.…”

Section: Discussionmentioning

confidence: 99%

Effect of Carcinogen 1,2-Dimethylhydrazine Treatment on Fiber Types in Skeletal Muscles of Male Wistar Rats

Smerdu

Perše²

2017

Physiol Res

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The cancerogen 1,2-dimethylhydrazine (DMH), widely used in the experimental animal model of carcinogenesis, affects various organs, but its effect on muscle fibers is unknown. To evaluate the effect of 15-week DMH treatment on the fiber size and myosin heavy chain (MyHC) isoforms, which substantially determine fiber types and their contractile characteristics, pure and hybrid fiber types were immunohistochemically determined according to the MyHC isoform expression in soleus, extensor digitorum longus, gastrocnemius medialis and lateralis muscles of DMH-treated and control male Wistar rats. Whereas the size of fibers was mostly unaffected, the MyHC isoform expression was partially affected in both gastrocnemius samples, but not in the soleus and extensor digitorum longus of DMH-treated rats. The lower proportions of hybrid fiber types and especially that of type 1/2x in most gastrocnemius samples of DMH-treated rats resulted in a shift towards a single MyHC isoform expression, but the extent and pattern of the MyHC isoform shift varied across the different gastrocnemius samples. Such variable response to DMH treatment across muscles indicates that each muscle possesses its own adaptive range. These findings are essential for an accurate evaluation of skeletal muscle characteristics in DMH animal model.

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Effect of altered innervation and thyroid hormones on myosin heavy chain expression and fiber type transitions: a mini-review

Cited by 19 publications

References 76 publications

Heat Treatment Inhibits Skeletal Muscle Atrophy of Glucocorticoid-Induced Myopathy in Rats

Heat Treatment Inhibits Skeletal Muscle Atrophy of Glucocorticoid-Induced Myopathy in Rats

Thyroid Hormone Transporters MCT8 and OATP1C1 Control Skeletal Muscle Regeneration

Effect of Carcinogen 1,2-Dimethylhydrazine Treatment on Fiber Types in Skeletal Muscles of Male Wistar Rats

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