1983
DOI: 10.1007/bf02405056
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Effect of aluminum on normal and uremic rats: Tissue distribution, vitamin D metabolites, and quantitative bone histology

Abstract: The effects of intraperitoneal aluminum chloride (1.5 mg aluminum/kg/day for 9 weeks) were studied in normal and uremic rats. Parameters measured included tissue aluminum, serum vitamin D metabolites, and quantitative bone histology. Aluminum administration increased tissue concentrations of this metal in uremic and nonuremic animals. Bone aluminum concentrations were higher in uremic rats (121 +/- 27 mg/kg compared to 47 +/- 4), whereas liver values were higher in the nonuremic group (175 +/- 47 mg/kg compare… Show more

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Cited by 91 publications
(30 citation statements)
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“…The results of the current investigation are consistent with previous reports in the dog (14) and in the rat (12,13,15,27) and demonstrate that the administration of aluminum to experimental animals is associated with the development of osteomalacia in conjunction with evidence of aluminum deposition in bone. All aluminum-treated animals developed osteomalacia during the course of study as judged by established histologic criteria despite increases in the serum levels ofboth calcium and phosphorus and maintenance of normal renal function.…”
Section: Discussionsupporting
confidence: 92%
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“…The results of the current investigation are consistent with previous reports in the dog (14) and in the rat (12,13,15,27) and demonstrate that the administration of aluminum to experimental animals is associated with the development of osteomalacia in conjunction with evidence of aluminum deposition in bone. All aluminum-treated animals developed osteomalacia during the course of study as judged by established histologic criteria despite increases in the serum levels ofboth calcium and phosphorus and maintenance of normal renal function.…”
Section: Discussionsupporting
confidence: 92%
“…This change has been documented in both clinical and experimental studies (1)(2)(3)(4)(5)(10)(11)(12)(13)(14), and several groups of investigators have reported an inverse relationship between the aluminum content of bone and the rate of bone formation in patients with aluminum-associated bone disease (2)(3)(4)28). The results ofthe current investigation are consistent with these earlier observations, but they also suggest that the disturbance in mineralized bone formation during aluminum administration is mediated by reductions in the number ofsites ofactive bone formation, whereas the function of bone cells at these sites is not impaired.…”
Section: Discussionmentioning
confidence: 86%
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“…(12) described a defect in the mineralization of newly formed bone at the tibial epiphyses of rats given aluminum; this was reversed when the administration of aluminum was stopped. Two other reports have also suggested that aluminum administration can induce osteomalacia in the trabecular bone of rats with renal insufficiency (13)(14). However, the results of these studies, as well as observations from our laboratory, indicate that rats given daily intraperitoneal injections of aluminum chloride exhibit less weight gain and slower bone growth than saline-injected control animals.…”
Section: Introductionmentioning
confidence: 46%
“…1984b;VukiEevid et af. 1987) and others failing to demonstrate an effect of A1 (Chan et al 1983; Sedman et al 1987). Some of the effects may be species-or dose-specific, or both.…”
Section: I V E Rmentioning
confidence: 99%