Effect of Ambrotose AO® on resting and exercise-induced antioxidant capacity and oxidative stress in healthy adults

Canale, Robert E.; Blankenship, Megan; Fisher‐Wellman, Kelsey H.

doi:10.1186/1475-2891-9-49

Cited by 15 publications

(12 citation statements)

References 35 publications

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“…These findings are supported by previous literature, in particular with regards to higher oxidative stress in men compared to women [47] and in obese compared to overweight and/or normal weight subjects [48,49]. With regards to the antioxidant capacity in exercise-trained compared to untrained subjects, mixed results are available; some supporting our finding of lower antioxidant capacity in trained individuals [50] and some refuting this [51,52]. Those findings in support of our data may be linked to the acute increase in ROS experienced by exercise-trained individuals, which may partially deplete endogenous antioxidants over time [50].…”

Section: Discussionsupporting

confidence: 90%

A 21 day Daniel Fast improves selected biomarkers of antioxidant status and oxidative stress in men and women

et al. 2011

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BackgroundDietary modification via both caloric and nutrient restriction is associated with multiple health benefits, some of which are related to an improvement in antioxidant status and a decrease in the production of reactive oxygen species. The Daniel Fast is based on the Biblical book of Daniel, is commonly partaken for 21 days, and involves food intake in accordance with a stringent vegan diet. The purpose of the present study was to determine the effect of a 21 day Daniel Fast on biomarkers of antioxidant status and oxidative stress.Methods43 subjects (13 men; 30 women; 35 ± 1 yrs; range: 20-62 yrs) completed a 21 day Daniel Fast following the guidelines provided by investigators. Subjects reported to the lab in a 12 hour post-absorptive state both pre fast (day 1) and post fast (day 22). At each visit, blood was collected for determination of malondialdehyde (MDA), hydrogen peroxide (H2O2), nitrate/nitrite (NOx), Trolox Equivalent Antioxidant Capacity (TEAC), and Oxygen Radical Absorbance Capacity (ORAC). Subjects recorded dietary intake during the 7 day period immediately prior to the fast and during the final 7 days of the fast.ResultsA decrease was noted in MDA (0.66 ± 0.0.03 vs. 0.56 ± 0.02 μmol L-1; p = 0.004), while H2O2 demonstrated a trend for lowering (4.42 ± 0.32 vs. 3.78 ± 0.21 μmol L-1; p = 0.074). Both NOx (18.79 ± 1.92 vs. 26.97 ± 2.40 μmol L-1; p = 0.003) and TEAC (0.47 ± 0.01 vs. 0.51 ± 0.01 mmol L-1; p = 0.001) increased from pre to post fast, while ORAC was unchanged (5243 ± 103 vs. 5249 ± 183 μmol L-1 TE; p = 0.974). As expected, multiple differences in dietary intake were noted (p < 0.05), including a reduction in total calorie intake (2185 ± 94 vs. 1722 ± 85).ConclusionModification of dietary intake in accordance with the Daniel Fast is associated with an improvement in selected biomarkers of antioxidant status and oxidative stress, including metabolites of nitric oxide (i.e., NOx).

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Section: Discussionsupporting

confidence: 90%

A 21 day Daniel Fast improves selected biomarkers of antioxidant status and oxidative stress in men and women

et al. 2011

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“…Ambrotose AO at a daily dosage of 4 capsules per day increases resting blood antioxidant capacity and may enhance post exercise antioxidant capacity. However, no statistically detected difference is observed in resting or exercise-induced oxidative stress biomarkers, in quality of life, or in tread mill test time to exhaustion [32] . Probiotic lactic acid producing bacteria have been shown to prevent and alleviate gastrointestinal disturbances and to normalize the cytokine profile which might be an advantage for patients suffering from chronic fatigue syndrome (CFS).…”

Section: E F F E C T O F a L O E V E R A J U I C E T O Chronic Fatigumentioning

confidence: 78%

Putative Prophylaxes of Aloe Vera Juice with L-arginine to Chronic Fatigue Syndrome

Yagi

Ataka

2016

Journal of Gastroenterology and Hepatology Research

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L-Arginine is one of the most metabolically versatile amino acids. Several in vitro/in vivo experiments have indicated that exogenous L-arginine intake has multiple beneficial pharmacological and pharmaco-kinetic effects. Such effects include reduction in the risk of vascular and heart diseases and chronic fatigue syndrome. The effects of a dietary supplementation of aloe vera juice with L-arginine to chronic fatigue syndrome were demonstrated and a questionnaire was given to adult subjects. The questionnaire included 10 points regarding their mental, circulatory and muscle functions. Table 1 and 2 summarize the most noteworthy information on supplementation of aloe vera juice with L-arginine. The demonstrated benefits of aloe vera juice with L-arginine show promises to chronic fatigue syndrome in adult subjects.

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“…The benefit of antioxidant supplementation on health outcomes have become of increasing interest due to controversial findings of both beneficial and non-beneficial, even detrimental effects in humans of high intakes of antioxidant supplementation ( Biesalski, Grune, Tinz, Zollner, & Blumberg, 2010 ; von Arnim et al, 2012) . The antioxidant preparation used have been shown in a 21-day randomized, double-blind, placebo-controlled crossover trial of 25 healthy adults to significantly increase two measures of antioxidant capacity in the blood: oxygen radical absorbance capacity (ORAC) and Trolox Equivalent Antioxidant Capacity (TEAC) ( Bloomer, Canale, Blankenship, & Fisher-Wellman, 2010 ). Two earlier open-label studies using the same preparation on healthy adults showed significant increases in serum ORAC, between 36.6% to 37.4%, compared with baseline ( Boyd et al, 2003 ; Myers et al, 2010) .…”

Section: Discussionmentioning

confidence: 99%

The Effect of Dietary Supplements on the Quality of Life of Retired Professional Football Players

Sinnott

Maddela

Bae³

et al. 2012

GJHS

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Professional football players may experience negative health consequences when they retire such as chronic pain, cognitive problems as well as other consequences of sports-related injuries. The purpose of this pilot study is to determine the effects of dietary supplementation with multiple nutrients on the quality of life of retired football players. Fifteen retired players received daily supplementation of fish oil with cholecalciferol, antioxidants, natural vitamins and minerals, polysaccharides and phytosterol-amino acid complex for 6 months. Using an open-labeled repeated measures design, volunteers completed self-report assessment measures at baseline, 1, 3 and 6 months. Outcome measures were CDC HRQOL-4, WHOQOL-BREF, POMS, MFQ and pain self-assessment. General health rating improvement on CDC HRQOL-4 from month 1 was sustained to month 6 (p<0.0001). Mental health days improved at 6 months (p<0.05). WHOQOL-BREF showed increased health satisfaction at all measurement points (p<0.05) and the Physical and Psychological Domain Scores at 6 months (p<0.05). MFQ General Rating of Memory improved at 3 and 6 months (p<0.05). Vigor scale in POMS was significant at 3 months (p<0.05). Decreased pain was noted only for the elbow at month 1 and the knee at month 3 (p<0.05). No adverse events were reported. Results of this study offer preliminary insight into using dietary supplements to support and optimize quality of life in retired football players. Further research using a placebo-controlled design is needed to characterize the potential benefit to physical and psychological well-being of multiple dietary supplementations for this cohort.

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Effect of Ambrotose AO® on resting and exercise-induced antioxidant capacity and oxidative stress in healthy adults

Cited by 15 publications

References 35 publications

A 21 day Daniel Fast improves selected biomarkers of antioxidant status and oxidative stress in men and women

A 21 day Daniel Fast improves selected biomarkers of antioxidant status and oxidative stress in men and women

Putative Prophylaxes of Aloe Vera Juice with L-arginine to Chronic Fatigue Syndrome

The Effect of Dietary Supplements on the Quality of Life of Retired Professional Football Players

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