Effect of amine functionalization of spherical MCM-41 and SBA-15 on controlled drug release

Szegedi, Ágnes; Popova, Margarita; Goshev, Ivan; Mihály, Judith

doi:10.1016/j.jssc.2011.03.005

Cited by 173 publications

(110 citation statements)

References 38 publications

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“…In addition, the peak at 1650 cm -1 , which can be assigned to N-H bending, is intensive for the MCM-NH 2 and KCC-NH 2 which would indicate the presence of N-H groups. Strong vibrational peaks were also seen in the C-H stretching region around 2900 cm -1 in MCM-NH 2 and KCC-NH 2 ( Figure 6C) [51,55]. Furthermore, the results obtained by FTIR for amine-modified materials proved the efficiency of the functionalization of the mesoporous silica.…”

Section: Drug Loading and Characterization N 2 Adsorption/desorption mentioning

confidence: 77%

pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles

AbouAitah¹,

Aa²,

Świderska-Środa³

et al. 2016

J Nanomed Nanotechnol

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Section: Drug Loading and Characterization N 2 Adsorption/desorption mentioning

confidence: 77%

pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles

AbouAitah¹,

Aa²,

Świderska-Środa³

et al. 2016

J Nanomed Nanotechnol

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“…Then the powdered products were washed 3 times with 5 ml water, and dried at 40°C Nitrogen physisorption measurements were carried out at -196°C using Thermo Scientific Surfer automatic volumetric adsorption analyzer. Before the analysis, silica samples were outgassed under high vacuum for 2 h at 250°C, whereas drug loaded samples were pretreated at 80°C for 3 h [28,29]. The pore-size distributions were calculated from the desorption isotherms by the BJH method.…”

Section: Quercetin Loadingmentioning

confidence: 99%

Preparation of efficient quercetin delivery system on Zn-modified mesoporous SBA-15 silica carrier

Trendafilova

Szegedi

Mihály

et al. 2017

Materials Science and Engineering: C

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Mesoporous silica material type SBA-15 was modified with different amounts of Zn (2 and 4 wt. %) by incipient wetness impregnation method in ethanol. The parent, Zn-modified and quercetin loaded samples, were characterized by XRD, N2 physisorption, TEM, thermal gravimetric analysis, UV-Vis and FT-IR spectroscopies and in vitro release of quercetin at pH 5.5 which is typical of dermal formulations. By this loading method anhydrous quercetin was formed on the silica carrier. It was found that the different hydrate forms of quercetin (dihydrate, monohydrate, anhydrite) significantly influence the physico-chemical properties of the delivery system. It was found that hydrate forms of quercetin can be differentiated by XRD and by FT-IR spectroscopic methods. Thus, by evaluating the interaction of the drug with the silica carrier the changes due to its hydration state always have to be taken into account. Formation of Zn-quercetin complex was evidenced on zinc modified SBA-15 silica by FT-IR spectroscopy. High quercetin loading capacity (over 40 wt. %) could be achieved on the parent and Zn-containing SBA-15 samples. The in-vitro release process at pH=5.5 showed slower quercetin release from Zn-modified SBA-15 samples compared to the parent one.Additionally, the comparative cytotoxic experiments evidenced that quercetin encapsulated in Zn-modified silica carriers has superior antineoplastic potential against HUT-29 cells compared to free drug. Zn-modified SBA-15 silica particles could be promising carriers for dermal delivery of quercetin.

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“…Silica samples with ordered porous structure we prepared by adapting earlier reported procedures [4,14]. Szegedi and co-workers synthesized silica ordered matrix by using CTAB, TEOS in ethanol and water mixture and base catalyst NH 3 [14] Tan and co-workers synthesized porous silica nanoparticles by using CTAB, TEOS in 2-ethoxyethanol and water mixture and base catalyst NH 3 [4].…”

Section: Sample Synthesismentioning

confidence: 99%

Pore ordering in mesoporous matrices induced by different directing agents

et al. 2014

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Mesoporous silica particles of MCM-41 type were synthesized by sol-gel method from tetraethyl orthosilicate (TEOS) in 2-methoxyethanol and deionized water mixture in base conditions at room temperature. Ammonia or sodium hydroxides were used as catalysts and cetyl-trimethylammonium bromide (CTAB) and n-dodecyl-trimethylammonium bromide (DTAB) as structure directing agents. The porosities and the ordered structure have been analyzed using transmission and scanning electron microscopy, small angle neutron and Xray diffraction, nitrogen adsorption, thermal analysis and FTIR spectroscopy. The samples consist of spherical particles of sub-micrometer size, with radially arranged pores. The comparison of the effect of the different surfactants and catalysts shows that by varying the surfactant type and their proportion, the pore sizes can be controlled. As compared to the commonly used ammonia catalyst, the use of NaOH as catalyst results in a much smaller porosity of the as-prepared materials. These materials are not resisting to the heat treatment at 700 ºC used for the template removal, and the ordered porous structure is completely lost.

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Effect of amine functionalization of spherical MCM-41 and SBA-15 on controlled drug release

Cited by 173 publications

References 38 publications

pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles

pH-controlled Release System for Curcumin based on Functionalized Dendritic Mesoporous Silica Nanoparticles

Preparation of efficient quercetin delivery system on Zn-modified mesoporous SBA-15 silica carrier

Pore ordering in mesoporous matrices induced by different directing agents

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