Effect of Aminoethylpyrroles on Carrageenan-induced Inflammation and on Lipid Peroxidation in Rats: Some Structural Aspects

Abstract

Nine 3-(2-aminoethyl)pyrrole derivatives were investigated as anti-inflammatory agents in the carrageenan-induced rat paw oedema model and as antioxidants in the non-enzymatic lipid peroxidation assay. It was found that the derivatives which were substituted with a p-toluenesulphonyl group exhibited considerable anti-inflammatory activity and some also showed antioxidant properties. However, the presence of a p-toluenesulphonyl group did not invariably lead to activity. A structural feature which was essential for both activities was the aminoethyl side chain. Although a relationship between the antiinflammatory and the antioxidant activities was not apparent, the combination of these properties could be useful.

Antioxidant and anti-inflammatory properties of C-phycocyanin from blue-green algae

“…The procedure was carried out as described [14]. The microsomes All the spectrophotometric measurements were done in a Spekol 220 from Carl Zeiss (Jena, Germany).…”

An Efficient One-Pot, Three-Component Synthesis of Tetrasubstituted Pyrroles under Catalyst- and Solvent-Free Conditions

“…Among these aspects, solvent-free neat reaction for the synthesis of N -heterocycles is significant, as they reduce wastage of solvents, undesirable side reactions associated with solvents, thus improving the overall efficiency of the reaction, can be performed in shorter duration, and the process is economically viable. Pyrrole, the simplest five-membered N -heterocycle, is found in several natural products 5 and possess varied biological activities like anti-inflammatory, 6a b antiviral, 6c anticancer, 6d antioxidant, 6e fungicidal, 6f antimicrobial, 6g and antihyperglycemic activity 6h thus finding its way in several marketed drugs like ketorolac, atorvastatin, etc. 7…”

Pharmacologic Application of Fourier Transform Infrared Spectroscopy: The in vivo Toxic Effect of Carrageenan

“…Lipid peroxides are in this way released and are highly pro-in ammatory. 13 In the present work we describe an application of transm ission FT-IR spectroscopy to highlight and characterize biocellular damages induced by carrageenan on various rat organs. Moreover, the mathematical exploitation of spectral data allowed us to extract m ore information useful for classi cation of the samples, to analyze and compare the level of chemical damage, and to correlate it with the biocellular m etabolism disturbed by the xenobiotic.…”