Effect of Aminophylline on High-energy Phosphate Metabolism and Fatigue in the Diaphragm

Abstract

Aminophylline, in a dose-dependent fashion, delays the onset of fatigue and improves recovery from fatigue. Delayed fatigue is associated with improved aerobic metabolism as reflected in a low Pi/PCr ratio.

Bioenergetics and intermuscular fat in chronic obstructive pulmonary disease‐associated quadriceps weakness

“…Subjects were not permitted to consume caffeine‐containing products or methylxanthine preparations from midnight on the day of scanning . Undisclosed smoking was excluded by measurement of exhaled carbon monoxide.…”

Almitrine and doxapram decrease fatigue and increase subsequent recovery in isolated rat diaphragm

“…Almitrine may act like the agent aminophylline, a compound also reported to improve diaphragmatic con-tractility (2,3,18) and reverse diaphragmatic fatigue (12). It is thought that aminophylline increases diaphragmatic contractility by increasing intracellular calcium concentration (9) as well as changing highenergy P i metabolism (15). Almitrine and doxapram may also increase intracellular calcium by either increasing calcium flow into the cell or preventing its Fig.…”

Dopamine alleviation of diaphragm contractile dysfunction and reduction of deoxyribonucleic acid damage in rats

“…13,17 For example, free radical scavengers N-acetylcysteine and aminophylline have been shown to attenuate diaphragm fatigue. [18][19][20] Research has shown that mitochondria stimulates the release of oxidants from the cells. [21][22][23] These oxidants may activate various apoptotic pathways.…”