Effect of amlodipine on exercise‐induced platelet activation in patients affected by chronic stable angina

Sanguigni, Valerio; Gallù, Mariacarla; Sciarra, Luigi; Cannata, D; Strano, A; Principe, Domenico Del; Menichelli, A; Palumbo, Giovanni

doi:10.1002/clc.4960220907

Cited by 3 publications

(4 citation statements)

References 36 publications

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“…For example, Sanguigni et al reported inhibition of exercise induced increase of expression of P-selectin after amlodipine in patients with chronic stable angina. 20 Our study, using the sensitive fluorescent probe for the first time to investigate changes in cytosolic calcium concentration of platelets during PTCA, found that platelet [Ca 2+ ] i significantly increased immediately after PTCA, with an obvious decrease 24 hours after PTCA. There was a statistical correlation between the changes in platelet [Ca 2+ ] i and those in the parameters of platelet activation measured.…”

Section: Discussionmentioning

confidence: 69%

Effects of diltiazem on platelet activation and cytosolic calcium during percutaneous transluminal coronary angioplasty

Dai

Chen

Qiu

et al. 2003

Postgraduate Medical Journal

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Aims: To evaluate effects of diltiazem on platelet hyper-reactivity in situations associated with endothelial injury and their possible relationship to cytosolic calcium concentration. Methods: Blood samples were collected at seven time points from 35 patients undergoing percutaneous transluminal coronary angioplasty (PTCA) who received combined diltiazem and aspirin/ ticlopidine therapy or aspirin/ticlopidine therapy alone. Platelet expression of glycoprotein IIb/IIIa and P-selectin, production of thromboxane B 2 , and cytosolic calcium concentration were measured, respectively, by whole blood flow cytometry, radioimmunoassay, and fluorospectrophotometry. The effects of diltiazem of different concentrations on expression of glycoprotein IIb/IIIa and P-selectin were also studied in vitro in blood samples from patients with chronic stable angina. Results: Of the two treatments, aspirin/ticlopidine therapy did not prevent an acute increase of expression of glycoprotein IIb/IIIa and P-selectin and plasma thromboxane B 2 five minutes and 10 minutes after first inflation and 10 minutes after PTCA, whereas combined diltiazem and aspirin/ticlopidine therapy had a significant inhibitory effect. In the group receiving aspirin/ticlopidine therapy, there was a short term increase of platelet [Ca 2+ ] i immediately after PTCA which was significantly reduced by diltiazem treatment. Expression of glycoprotein IIb/IIIa and P-selectin was significantly inhibited in vitro by diltiazem in the concentration of 200 ng/ml or higher, but not 50 ng/ml. Conclusions: Combined diltiazem and aspirin/ticlopidine therapy significantly inhibited platelet activation that continued in the presence of conventional aspirin/ticlopidine treatment. Antiplatelet effects of diltiazem were probably a consequence of reduction of platelet [Ca 2+ ] i and may only be achieved in higher than therapeutic concentrations.

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Section: Discussionmentioning

confidence: 69%

Effects of diltiazem on platelet activation and cytosolic calcium during percutaneous transluminal coronary angioplasty

Dai

Chen

Qiu

et al. 2003

Postgraduate Medical Journal

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“…Among the studies, 8 of them used a bicycle ergometer test, [ 11 , 13 , 15 , 16 , 20 , 21 , 26 , 29 ] starting at a load of 25w-50w and increased by 20w-25w/2minuts; and ten studies used treadmill exercise according to standard or modified Bruce protocol. [ 12 , 14 , 17 , 19 , 22 – 25 , 28 , 30 ] Limited symptom or heart rate >85% predicted or ECG change or exhaust was used in most studies as terminate criteria in patients group, while exhaust was used in healthy controls.…”

Section: Resultsmentioning

confidence: 99%

“…[ 15 ] In addition, Sanguigni et al revealed that Amlodipine partially inhibited the exercise-induced augmentation of CD62p + platelet in patients with CAD. [ 29 ]…”

Section: Resultsmentioning

confidence: 99%

“…[ 32 ] Amlodipine also exhibited a favorable effect on exercise-induced platelet activation within CAD patients. [ 29 ] Additionally, underappreciated differences of drug regime across various study groups may contribute to the conflicting results, and more studies of drug effects (e.g., anti-hypertensive and anti-diabetic drugs, statins, nitrates, etc.) on exercise-induced platelet activation are required.…”

Section: Discussionmentioning

confidence: 99%

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Influence of exercise test on platelet function in patients with coronary arterial disease

Wang

Yue

et al. 2021

Medicine

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Background: Exercise test (ET) may have adverse effects on platelet function and induce acute thrombotic events in patients with coronary artery disease (CAD). The aim of this study is to investigate the platelet function and evaluate the risk of thrombotic events in CAD patients during ET. Methods: Pubmed, Embase, Cochrane Library, and Web of Science were searched for a systematic review from initiation to October 2019. The inclusion criteria were controlled clinical trails as study design; investigating platelet function in CAD patients during ET; with ET carried out by treadmill or bicycle ergometer; written in English. Included articles were screened based on title/abstract and full-text review by 2 independent reviewers. Platelet aggregation (PA), platelet surface expression of CD62p and PAC-1, plasma levels of platelet factor 4 (PF4) and beta-thromboglobulin (β-TG) were evaluated before and after ET. Results: Eighteen articles were included out of the 427 references initially identified. In most of the studies included ET was terminated because of limited symptoms. Prior to ET, no difference in platelet aggregation was observed in CAD patients compared with healthy controls in majority of the studies, with or without the treatment with Aspirin. Dual anti-platelet therapy suppressed adenosine diphosphate (ADP)-induced platelet aggregation at rest. After ET, platelet aggregation, the serum levels of β-thromboglobulin were found unchanged in majority of studies and platelet factor-4 were found unchanged in half of studies. The expression of platelet surface markers were elevated by ET in a few study. Conclusion: Symptom-limited exercise test did not affect platelet function in patients with coronary artery disease; however exercise to higher intensity may induce platelet activation.

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Potential Protective Role of Blood Pressure-Lowering Drugs on the Balance between Hemostasis and Fibrinolysis in Hypertensive Patients at Rest and During Exercise

Braschi¹

2019

Am J Cardiovasc Drugs

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Effect of amlodipine on exercise‐induced platelet activation in patients affected by chronic stable angina

Cited by 3 publications

References 36 publications

Effects of diltiazem on platelet activation and cytosolic calcium during percutaneous transluminal coronary angioplasty

Effects of diltiazem on platelet activation and cytosolic calcium during percutaneous transluminal coronary angioplasty

Influence of exercise test on platelet function in patients with coronary arterial disease

Potential Protective Role of Blood Pressure-Lowering Drugs on the Balance between Hemostasis and Fibrinolysis in Hypertensive Patients at Rest and During Exercise

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