Effect Of Amodiaquine Plus Artesunate Combination On Some Macromolecules In The Brain Of Albino Wistar Rats

doi:10.5580/1015

IJH

2008

DOI: 10.5580/1015

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Effect Of Amodiaquine Plus Artesunate Combination On Some Macromolecules In The Brain Of Albino Wistar Rats

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Cited by 4 publications

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Effect of Artesunate Treatment on Some Brain Biomolecules and its Behavioral Implication

Ekong

Igri

Ekanem

1970

J Bangladesh Soc Physiol

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AbstractsBackground: Artesunate (AS) is an artemisinin antimalarial drug used as a single drug or in combination with other antimalarials. Objective: This study was to find its effect on some brain biomolecules and behavioural activities in Wistar rats. Methods:Forty adult male Wistar rats weighing between 150-180g were divided into four groups of A, B, C and D with 10 animals each. Group A served as the control that received tap water, while groups B, C and D served as the experimental groups that received 2.85mg/kg (therapeutic dose-TD) and 5.71mg/kg (high pharmacologic dose-HPD) of AS per day for 3 days, and 2.85mg/kg (long duration therapeutic dose -LDTD) of AS per day for six days respectively. Half of the dose was administered twelve hourly (twice a day), and twelve hours after the last treatments, behaviour test using the 'open field maze' was carried out. Immediately after, the animals were sacrificed with chloroform anaesthesia and the whole brain removed and weighed. Whole brain homogenates were used to determine brain total protein (TP), triacylglycerol (TAG) and cholesterol (CH).Data were analyzed statistically by ANOVA and Tukey-Kramer Multiple Comparative Test as applicable. Results: There were no difference (p<0.05) between the experimental groups and the control group in the anthropometric parameters and behavioural activities. In the brain biomolecules concentration, TP was lower in concentration in the HPD group, TAG was lower in concentration in the LDTD group, while the HPD and LDTD groups had lower CH concentration compared to the control. In all the parameters studied no difference was found between the TD group and the control. Conclusion: AS at recommended dose may not affect some behaviour and brain biomolecule concentration, unlike when taken in excess of dose and or time. Even at these doses/time there may have been no behavioural manifestation.

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Effect of Artesunate Treatment on Some Brain Biomolecules and its Behavioral Implication

Ekong

Igri

Ekanem

1970

J Bangladesh Soc Physiol

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The effect of amodiaquine on some brain macromolecules of Wistar rats

Ekong¹,

Igiri²,

Ekanem³

et al. 2009

International Journal of Biological and Chemical Sciences

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Amodiaquine (AQ) is a 4-aminoquinoline antimalarial with schizonticidal action against different strains of Plasmodia. This study assessed the effect of the drug on some macromolecules of the brain of albino Wistar rats. Twenty-four adult Wistar rats weighing between 150-180 g were divided into four groups of six animals each. Group 1 served as the control and received distilled water, while groups 2, 3 and 4, the experimental groups, were treated with 17.50 mg/kg, 8.75 mg/kg and 8.75 mg/kg of AQ, respectively. The treatment lasted three days for groups 2 and 3, and six days for group 4. The brains of the animals were removed, weighed and preserved in sucrose tris-KCl-MgCl (STKM) buffer for some macromolecule analysis. The total proteins (TP) and triacylglycerol (TAG) showed no significant (p>0.05) differences between the experimental groups compared to the control, and there was no significant (p>0.05) difference within the experimental groups. In the cholesterol (CH) estimation, the control had significantly (p<0.01, p<0.001) higher concentration than groups 3 and 4 respectively, but not group 2. CH concentration in group 2 was, however, significantly (p<0.05, p<0.01) higher than that in groups 3 and 4 respectively. These results reveal that AQ caused insignificant change to brain TP and TAG, but significantly altered the CH in the brain of Wistar rats.

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Effect of Oral Administration of Artesunate on the Histology of the Kidney in Albino Rat.

Amaza¹,

Momoh²,

Zirahei³

et al. 2013

IOSR-JDMS

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Abstract:The effect of oral administration of Artesunate on the histology of the Kidney of Albino Rat was determined histologically. Thirty Albino rats weighing 80-175g were divided into five groups (A-E) of five rats each. Group A (control) was give equal volume of distilled water daily. Group B received 4mg/kg/day of Artesunate for 5 days and were sacrificed on the 6th day. Group C were given 4mg/kg of Artesunate for the 1 st day, then 3mg/kg/day of Artesunate for 8 days and sacrificed on the 10 th day. Group D received 4mg/kg/day of Artesunate for the 1 st day, then 3mg/kg/day of Artesunate for 12 days and sacrificed on the 14 th day. Group E served as recovery group which received equal treatment as group D above and were left for 10 days later on vital feed and water and were sacrificed on the 23 rd day. The route of administration was orally by the use of the orogastric tube. The kidneys were removed and transferred immediately into 10% formalin. There were no marked differences between the change in weight of the control and the experimental. Administration of Artesunate to rats produced moderate to severe glomerular degeneration, focal haemorrhage, oedema, congested blood vessels, cloudy swelling of the tubules, necrosis of the tubule both in cortex and medulla. These findings were observed to be dose dependent. Artesunate may have acted as toxin to the neurons, affecting their structural integrity. It is therefore recommended that further studies aimed at corroborating this findings be carried out

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Effect Of Amodiaquine Plus Artesunate Combination On Some Macromolecules In The Brain Of Albino Wistar Rats

Cited by 4 publications

References 13 publications

Effect of Artesunate Treatment on Some Brain Biomolecules and its Behavioral Implication

Effect of Artesunate Treatment on Some Brain Biomolecules and its Behavioral Implication

The effect of amodiaquine on some brain macromolecules of Wistar rats

Effect of Oral Administration of Artesunate on the Histology of the Kidney in Albino Rat.

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