Effect of Amphotericin B antibiotic on the properties of model lipid membrane

Kiryakova, S; Dencheva-Zarkova, Maria; Genova, Julia

doi:10.1088/1742-6596/558/1/012027

Cited by 4 publications

(6 citation statements)

References 13 publications

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“…We found that the K C value decreased for the range of 0.5−5 mol % by ∼49%. So, the general trend, although not the absolute K C values of our results, agrees with that observed by Kiryakova et al 38 In addition, our results show a parallel behavior between the bending modulus and the order parameter: AmpB first stiffened the SoyPC/NaChol membrane at 200:1 mole ratio (0.005 mol fraction) and then significantly softened it at higher concentrations. AmpB also ordered chains at 200:1 mole ratio and then disordered chains at 20:1 mole ratio (0.05 mol fraction).…”

Section: Discussionsupporting

confidence: 93%

“…Kiryakova et al found that the K C values of (1-stearoyl-2-oleoyl- sn -glycero-3-phosphocholine) SOPC membranes and SOPC membranes with 40 mol % cholesterol both decrease with the addition of AmpB . They used the thermally induced shape fluctuation method to analyze their data, so their method for obtaining K C values was different from ours.…”

Section: Discussioncontrasting

confidence: 70%

“…We found that the K C value decreased for the range of 0.5–5 mol % by ∼49%. So, the general trend, although not the absolute K C values of our results, agrees with that observed by Kiryakova et al…”

Section: Discussionsupporting

confidence: 52%

“…Amphotericin B. Kiryakova et al found that the K C values of (1-stearoyl-2-oleoyl-sn-glycero-3-phosphocholine) SOPC membranes and SOPC membranes with 40 mol % cholesterol both decrease with the addition of AmpB. 38 They used the thermally induced shape fluctuation method to analyze their data, so their method for obtaining K C values was different from ours. Generally, absolute K C values obtained with the shape analysis are ∼1.5 times greater than the values obtained using diffuse X-ray scattering.…”

Section: Discussionmentioning

confidence: 84%

“…Effect of AmpB on K C in SoyPC/NaChol, SOPC, and SOPC/cholesterol. K C values in SoyPC/NaChol are from this work, and K C values for SOPC and SOPC/cholesterol were reported by ref .…”

Section: Discussionmentioning

confidence: 99%

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Effect of Anti-Leishmania Drugs on the Structural and Elastic Properties of Ultradeformable Lipid Membranes

et al. 2018

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Drugs for treating Leishmaniasis, a parasitic tropical orphan disease, currently have several limitations on their use, which topical treatments could alleviate. Topical treatment requires penetration of drugs deep into the skin, which is aided by encapsulation within ultradeformable liposomes. Penetrability depends on the flexibility of the lipid membrane, which may be affected by the drugs. We have studied the biophysical effects of four anti-Leishmania drugs (miltefosine (Milt), amphotericin B (AmpB), indole (Ind), and imiquimod (Imiq)) on a soy phosphatidylcholine/sodium cholate membrane. Using diffuse X-ray scattering techniques, we determined bending modulus ( K) and chain order parameter ( S) of the membrane at several drug concentrations. Form factor scattering data allowed construction of electron density profiles, which yielded bilayer thickness and area per lipid. Results show that AmpB had the largest effect on K and S, causing the bilayer to lose integrity at high concentrations. Imiq and Ind induced slight membrane stiffening, whereas Milt had little effect. Imiq also notably decreased chain order at high concentrations. These results will aid in the design of new topical treatments, where Milt, Ind, and Imiq could be used at any concentration without affecting liposome integrity or physical properties, whereas AmpB should not be used at high concentrations.

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Section: Discussionsupporting

confidence: 93%

Section: Discussioncontrasting

confidence: 70%

Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 84%

“…Effect of AmpB on K C in SoyPC/NaChol, SOPC, and SOPC/cholesterol. K C values in SoyPC/NaChol are from this work, and K C values for SOPC and SOPC/cholesterol were reported by ref .…”

Section: Discussionmentioning

confidence: 99%

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Effect of Anti-Leishmania Drugs on the Structural and Elastic Properties of Ultradeformable Lipid Membranes

et al. 2018

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The antimicrobial and immunomodulatory effects of Ionophores for the treatment of human infection

Oliveira

Walker

2022

Journal of Inorganic Biochemistry

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Outwitting an Old Neglected Nemesis: A Review on Leveraging Integrated Data-Driven Approaches to Aid in Unraveling of Leishmanicides of Therapeutic Potential

Kwofie

Broni

Dankwa

et al. 2020

CTMC

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The global prevalence of leishmaniasis has increased with skyrocketed mortality in the past decade. The causative agent of leishmaniasis is Leishmania species, which infects populations in almost all the continents. Prevailing treatment regimens are consistently inefficient with reported side effects, toxicity and drug resistance. This review complements existing ones by discussing the current state of treatment options, therapeutic bottlenecks including chemoresistance and toxicity, as well as drug targets. It further highlights innovative applications of nanotherapeutics-based formulations, inhibitory potential of leishmanicides, anti-microbial peptides and organometallic compounds on leishmanial species. Moreover, it provides essential insights into recent machine learning-based models that have been used to predict novel leishmanicides and also discusses other new models that could be adopted to develop fast, efficient, robust and novel algorithms to aid in unraveling the next generation of anti-leishmanial drugs. A plethora of enriched functional genomic, proteomic, structural biology, high throughput bioassay and drug-related datasets are currently warehoused in both general and leishmania-specific databases. The warehoused datasets are essential inputs for training and testing algorithms to augment the prediction of biotherapeutic entities. In addition, we demonstrate how pharmacoinformatics techniques including ligand-, structure- and pharmacophore-based virtual screening approaches have been utilized to screen ligand libraries against both modeled and experimentally solved 3D structures of essential drug targets. In the era of data-driven decision-making, we believe that highlighting intricately linked topical issues relevant to leishmanial drug discovery offers a one-stop-shop opportunity to decipher critical literature with the potential to unlock implicit breakthroughs.

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Effect of Amphotericin B antibiotic on the properties of model lipid membrane

Cited by 4 publications

References 13 publications

Effect of Anti-Leishmania Drugs on the Structural and Elastic Properties of Ultradeformable Lipid Membranes

Effect of Anti-Leishmania Drugs on the Structural and Elastic Properties of Ultradeformable Lipid Membranes

The antimicrobial and immunomodulatory effects of Ionophores for the treatment of human infection

Outwitting an Old Neglected Nemesis: A Review on Leveraging Integrated Data-Driven Approaches to Aid in Unraveling of Leishmanicides of Therapeutic Potential

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