Effect of Amygdalin on the treatment and recurrence of endometriosis in an experimental rat study

Doğru, Hatice Yılmaz

doi:10.18054/pb.v119i3.4767

Cited by 9 publications

(6 citation statements)

References 28 publications

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“…As mentioned earlier, the beneficial properties and health-promoting effects of amygdalin particularly on the treatment and recurrence of endometriosis have been reported [53]. Similarly, analogues of amygdalin with cyanide group removed may play a valuable role in improving the immune function of the organism [49].…”

Section: Application In Reproductive Biology and Medicinementioning

confidence: 87%

“…Therefore, regular intake of bitter apricot seeds may be considered potentially useful for the prevention of cardiovascular diseases [20]. Furthermore, the protective effect of amygdalin in the treatment and recurrence of endometriosis has been reported [53]. Additionally, semen Armeniacae amarum (a Chinese traditional medicine with its amygdalin content) is known to exert antitussive and anti-asthmatic effects [32].…”

Section: Physiological and Therapeutic Rolesmentioning

confidence: 99%

“…There is a significant amount of evidence for the role of amygdalin on male reproductive functions in animals [21,22,38,43,60], as well as female reproductive system in vivo and in vitro [23,53,[61][62][63][64]. Amygdalin application positively affects ovarian cell viability and stimulates testosterone release by porcine ovarian granulosa cells; therefore, amygdalin can exert a potential effect on cellular growth and the process of ovarian steroidogenesis in vitro [62].…”

Section: Effects On the Female Reproductionmentioning

confidence: 99%

“…Amygdalin application positively affects ovarian cell viability and stimulates testosterone release by porcine ovarian granulosa cells; therefore, amygdalin can exert a potential effect on cellular growth and the process of ovarian steroidogenesis in vitro [62]. In addition, amygdalin has an evident effect in the treatment of endometriosis, an aggressive disorder associated with infertility, pelvic pain, and intra-abdominal adhesions in women of reproductive age [53].…”

Section: Effects On the Female Reproductionmentioning

confidence: 99%

“…28 days male rabbits antioxidant effect positive [43] 5 mg/kg/week i.p. 42 days female rats protective effect against endometriosis positive [53] In vitro studies 0.5, 1, 2.5 and 5 mg/mL 5 h rabbit spermatozoa stimulatory effect positive [60] 1, 10, 100, 1000 and 10,000 µg/mL 24 h porcine ovarian cells stimulatory effect positive [61][62][63][64]…”

Section: Effects On the Female Reproductionmentioning

confidence: 99%

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The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction

2021

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The present review summarizes the current knowledge on the provenance and properties, metabolism and toxicity, mechanism of action, physiological, and therapeutic roles of amygdalin—a molecule present in the seeds of apricot and other plants—with an emphasis on the action of amygdalin on reproductive processes, particularly in the female. Amygdalin influences physiological processes including female reproduction at various regulatory levels via extra- and intracellular signaling pathways regulating secretory activity, cell viability, steroidogenesis, proliferation, and apoptosis. On the other hand, while being metabolized in the body, amygdalin releases significant amounts of cyanide, which may lead to acute health hazard in those individuals who may be at risk. Despite some contradictions in the available data about benefits and toxic effects of amygdalin, its potential applicability at low doses may present a promising tool for regulation of various reproductive and other physiological processes including disease management primarily in cancer phytotherapy, animal production, medicine, and biotechnology. However, further research involving carefully designed dose–response studies is required to overcome the possible side effects of amygdalin and assure its safety as a therapeutic agent.

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Section: Application In Reproductive Biology and Medicinementioning

confidence: 87%

Section: Physiological and Therapeutic Rolesmentioning

confidence: 99%

Section: Effects On the Female Reproductionmentioning

confidence: 99%

Section: Effects On the Female Reproductionmentioning

confidence: 99%

Section: Effects On the Female Reproductionmentioning

confidence: 99%

See 3 more Smart Citations

The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction

2021

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Repro-protective activity of amygdalin and spirulina platensis in niosomes and conventional forms against aluminum chloride–induced testicular challenge in adult rats: role of CYP11A1, StAR, and HSD-3B expressions

Abo El-Ela,

Gamal,

El-Banna

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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The male reproductive system is negatively influenced by Al exposure. Al represented a considerable hazard to men’s reproduction capabilities. Amygdalin (AMG) and spirulina platensis (SP) have been considered to have a strong antioxidant and repro-protective activity; also, targeted drug delivery systems called niosomes improve the distribution of water-soluble medications like amygdalin and spirulina. Current study targeted to determine the effectiveness of AMG and SP against negative reproductive impact resulted by aluminum chloride (AlCl3) toxicity. Sixty adult male albino rats were separated into 6 groups, including the control group, which received distilled water; AlCl3 group, which received AlCl3; AMG+AlCl3 group, which received AlCl3+AMG; AMGLN+AlCl3 group, which received AlCl3+amygdalin-loaded niosomes; SP+AlCl3 group, which received AlCl3+SP; and SPLN+AlCl3 group, which received AlCl3+spirulina-loaded niosomes. All treatments were orally gavaged daily for 5 weeks, and rats were weighed weekly. At the termination of the experiment, some males (three from each group) were used for fertility traits via mating thirty virgin rat females (in a ratio of 1:2 and 2:3 male:female, respectively) followed by recording of birth weights and litter size (number of pups per each female) at birth to assess males’ reproductive capability. Other males were euthanized for collection of serum, epididymal semen samples, and tissue samples for biochemical, sperm evaluation, gene expression, and histopathological measurements. There are a considerable number of negative impacts of AlCl3 on male fertility clarified by declined serum testosterone levels; an increased oxidative stress (MDA, TAC); deteriorated semen quality; down-regulation of CYP11A1, StAR, and HSD-3b gene expressions; and testicular tissue degenerative changes. In addition, litter size (number of pups per each female) and birth weights of pups obtained from mated females were affected. AMG and SP treatments, either in niosomal or conventional form, alleviated the AlCl3 negative effects by reducing oxidative stress; increasing testosterone levels; improving semen quality; upregulating of CYP11A1, StAR, and HSD-3b gene expressions; and reducing degenerative changes of testicular tissue. Besides, negative reproductive effect was diminished as observed by changes in the litter size (number of pups per each female) and birth weights of pups obtained from mated females. AMG and SP treatments (either in niosomal or conventional form), ameliorated the AlCl3 negative effects as they possess powerful antioxidant activity, as well as they have the ability to improve the reproductive activity of affected males. Graphical abstract

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Food/medicinal herbs and their influence on health and female reproduction

Sirotkin¹,

Kolesárová²

2022

Environmental Contaminants and Medicinal Plants Action on Female Reproduction

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Effect of Amygdalin on the treatment and recurrence of endometriosis in an experimental rat study

Abstract: Conclusion: �e present study showed that amygdalin has an evident effect in the treatment of endometriosis.

Cited by 9 publications

References 28 publications

The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction

The Multiple Actions of Amygdalin on Cellular Processes with an Emphasis on Female Reproduction

Repro-protective activity of amygdalin and spirulina platensis in niosomes and conventional forms against aluminum chloride–induced testicular challenge in adult rats: role of CYP11A1, StAR, and HSD-3B expressions

Food/medicinal herbs and their influence on health and female reproduction

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