Effect of an aerobic and strength exercise combined program on oxidative stress and inflammatory biomarkers in patients undergoing hemodialysis: a single blind randomized controlled trial

Meléndez‐Oliva, Erika; Gómez-Trelles, Isabel Sánchez-Vera; Segura‐Ortí, Eva; Pérez‐Domínguez, Borja; García-Maset, Rafael; García-Testal, Alicia; Lavandera-Díaz, Jose Luis

doi:10.1007/s11255-022-03146-z

Cited by 9 publications

(12 citation statements)

References 39 publications

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“…The 24 studies included were conducted in Iran [ 19 ], Brazil [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ], Poland [ 30 ], the United Kingdom [ 31 , 32 , 33 , 34 , 35 , 36 ], Taiwan [ 37 ], China [ 38 ], Indonesia [ 39 ], Spain [ 40 , 41 ] and Greece [ 42 ], and published from 2010 to 2022.…”

Section: Resultsmentioning

confidence: 99%

“…The characteristics of the included studies are presented in Table 1 . The 24 studies were clinical trials, of which thirteen were randomized controlled trials [ 19 , 25 , 26 , 27 , 28 , 29 , 35 , 36 , 37 , 38 , 39 , 41 , 42 ], four were uncontrolled trials [ 20 , 21 , 30 , 40 ], one was a non-randomized clinical trial [ 23 ], one was a non-randomized controlled trial [ 32 ], four were randomized crossover trials [ 22 , 24 , 31 , 33 ], and one was a non-randomized crossover trial [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…The methodological quality of the studies was evaluated with the PEDro scale, and scores are shown in Table 2 . In total, seventeen studies were evaluated as being of excellent quality [ 19 , 22 , 24 , 25 , 26 , 27 , 28 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 41 , 42 ], two studies were of good quality [ 23 , 29 ] and five studies were of acceptable quality [ 20 , 21 , 30 , 32 , 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…In total, seventeen studies were evaluated. Five studies were at low risk of bias [ 26 , 28 , 31 , 37 , 39 ], five studies had an unclear risk [ 25 , 35 , 36 , 41 , 42 ] and seven studies were at high risk of bias [ 19 , 22 , 24 , 27 , 29 , 33 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, two studies found decreased levels of CRP after AE compared to usual care [ 33 , 37 ], one study found improvements favoring AE when compared to RT [ 19 ] and two studies found improvements after RT exercise [ 20 , 21 ]. Finally, when AE were combined with RT, one study reported decreased levels after intervention [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

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Effect of Exercise on Inflammation in Hemodialysis Patients: A Systematic Review

Meléndez‐Oliva

Villafañe

Pérez

et al. 2022

JPM

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Background: In recent years, physical exercise has been investigated for its potential as a therapeutic tool in patients with end-stage renal disease (ESRD) undergoing hemodialysis maintenance treatment (HD). It has been shown that regular practice of moderate-intensity exercise can improve certain aspects of immune function and exert anti-inflammatory effects, having been associated with low levels of pro-inflammatory cytokines and high levels of anti-inflammatory cytokines. Purpose: The aim of this review is to examine the studies carried out in this population that analyzed the effect of intradialytic exercise on the inflammatory state and evaluate which exercise modality is most effective. Methods: The search was carried out in the MEDLINE, CINAHL Web of Science and Cochrane Central Register of Controlled Trials databases from inception to June 2022. The PEDro scale was used to assess methodological quality, and the Cochrane Risk of Bias Tool and MINORS were used to evaluate the risk of bias. The quality of evidence was assessed with GRADE scale. The outcome measures were systemic inflammation biomarkers. Results: Mixed results were found in terms of improving inflammation biomarkers, such as CRP, IL-6 or TNFα, after exercise. Aerobic exercise seems to improve systemic inflammation when performed at medium intensity while resistance training produced better outcomes when performed at high intensity. However, some studies reported no differences after exercise and these results should be taken with caution. Conclusions: The low quality of the evidence suggests that aerobic and resistance exercise during HD treatment improves systemic inflammation biomarkers in patients with ESRD. In any case, interventions that increase physical activity in patients with ESRD are of vital importance as sedentary behaviors are associated with mortality. More studies are needed to affirm solid conclusions and to make intervention parameters, such as modality, dose, intensity or duration, sufficiently clear.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Effect of Exercise on Inflammation in Hemodialysis Patients: A Systematic Review

Meléndez‐Oliva

Villafañe

Pérez

et al. 2022

JPM

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Home-based exercise in dialysis patients with end-stage renal disease: A systematic review and meta-analysis of randomized controlled trials

Chen,

Guan,

Zhou

et al. 2024

Complementary Therapies in Clinical Practice

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The effect of aerobic exercise on oxidative stress in patients with chronic kidney disease: a systematic review and meta-analysis with trial sequential analysis

Zhao,

Xiao,

Tan

et al. 2023

Renal Failure

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Purpose The purpose of this study was to investigate how aerobic exercise affects oxidative stress (OS) in patients with chronic kidney disease (CKD). Methods Retrieval dates range from the date the database was established to 19 July 2023, without languages being restricted. A meta-analysis and sensitivity analysis were conducted using RevMan 5.3 and Stata 16.0. Results The meta-analysis showed that, compared to usual activity or no exercise, aerobic exercise significantly reduced the oxidative markers malondialdehyde (MDA) (mean differences (MD) − 0.96 (95% CI −1.33, − 0.59); p < 0.00001), advanced oxidation protein product (AOPP) (MD − 3.49 (95% CI − 5.05, − 1.93); p < 0.00001), F2-isoprostanes (F2-iso) (MD − 11.02 (95% CI − 17.79, − 4.25); p = 0.001). Aerobic exercise also increased the antioxidant marker superoxide dismutase (SOD) in CKD patients (standardized mean differences (SMD) 1.30 (95% CI 0.56, 2.04); p = 0.0005). Subgroup analysis showed a significant increase in glutathione peroxidase (GPX) in patients aged ≥60 years (SMD 2.11 (95% CI 1.69, 2.54); p < 0.00001). The change in total antioxidant capacity (TAC) after aerobic exercise was insignificant in patients with CKD. The trial sequential analysis supported aerobic exercise’s effectiveness in improving MDA, SOD, AOPP, and F2-iso in patients with CKD. Conclusion The results of this review suggest that aerobic exercise improves OS indicators (MDA, SOD, AOPP, and F2-iso) in CKD patients compared to conventional treatment or no exercise and that the effects on GPX and TAC indicators need further confirmation. For better validation of benefits and exploration of the best aerobic exercise regimen to improve OS status with CKD, further studies with high methodological quality and large sample sizes are needed.

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Effect of an aerobic and strength exercise combined program on oxidative stress and inflammatory biomarkers in patients undergoing hemodialysis: a single blind randomized controlled trial

Cited by 9 publications

References 39 publications

Effect of Exercise on Inflammation in Hemodialysis Patients: A Systematic Review

Effect of Exercise on Inflammation in Hemodialysis Patients: A Systematic Review

Home-based exercise in dialysis patients with end-stage renal disease: A systematic review and meta-analysis of randomized controlled trials

The effect of aerobic exercise on oxidative stress in patients with chronic kidney disease: a systematic review and meta-analysis with trial sequential analysis

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