Effect of an aqueous extract of Cucurbita ficifolia Bouché on the glutathione redox cycle in mice with STZ-induced diabetes

Díaz‐Flores, Margarita; Ángeles-Mejía, S.; Baiza-Gutman, Luís Arturo; Medina-Navarro, Rafael; Hernández-Saavedra, Daniel; Ortega-Camarillo, Clara; Román-Ramos, Rubén; Crúz, Miguel A.; Alarcón-Aguilar, Francisco Javier

doi:10.1016/j.jep.2012.08.036

Cited by 43 publications

(34 citation statements)

References 41 publications

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“…Moreover, protein levels of GPx and SOD isoforms are associated with oxidative damage and mitochondrial dysfunction through hydrogen peroxide (H 2 O 2 ) production by the glucose oxidase system [64–66]. A previous study [67] demonstrated that GPx activity was increased in diabetic mice organs including the liver, pancreas, and kidney. Our findings proved that genistein supplementation reduced GPx levels, except the DMH-0.1% group.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Short-Term Genistein Supplementation on the Early Stage in Diabetes-Induced Renal Damage

Kim

Lim

2013

Mediators of Inflammation

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Hyperglycemia-induced oxidative stress has been concerned in the development of diabetic nephropathy (DN), which may cause kidney damage associated with inflammation and fibrosis. This study has been conducted to investigate the role of genistein supplementation in an acute DN state. Mice with FBG levels more than 250 mg/dL after alloxan injection (single i.p., 150 mg/kg) were considered as diabetic. Diabetic mice (DM) were further subdivided according to their FBG levels, medium-high FBG (DMMH < 450 mg/dL) and high FBG (DMH; 450 mg/dL) and were administrated by an AIG-93G diet supplemented with different doses of genistein (0, 0.025 or 0.1%). After 2 weeks' treatment, the levels of kidney malondialdehyde (MDA), blood urea nitrogen (BUN), and plasma creatinine and lipid profiles, as well as oxidative stress and inflammation-related markers, were measured (P < 0.05). Genistein supplementation improved levels of FBG in the DMMH groups, but not in the DMH group, regardless of the treatment dose. Moreover, the supplementation attenuated kidney oxidative stress indicated by MDA, BUN, and plasma creatinine. In addition, genistein treatment decreased inflammatory markers such as nuclear factor kappa B (p65), phosphorylated inhibitory kappa B alpha, C-reactive protein, monocyte chemotactic protein-1, cyclooxygenase-2, and tumor necrosis factor-alpha and improved oxidative stress markers (nuclear-related factor E2, heme oxygenase-1, glutathione peroxidase, and superoxide dismutase isoforms) in treatment groups, regardless of the genistein treatment dose. Furthermore, genistein supplementation inhibited the fibrosis-related markers (protein kinase C, protein kinase C-beta II, and transforming growth factor-beta I) in the DN state. However, 0.1% genistein supplementation in diabetes with high FBG levels selectively showed a preventive effect on kidney damage. These results suggest that genistein might be a good protective substance for DN through regulation of oxidative stress and inflammation. In particular, genistein is more efficient in diabetes patients with medium-high blood glucose levels. Finally, it is required to establish the beneficial dosage of genistein according to blood glucose levels.

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Section: Discussionmentioning

confidence: 99%

Protective Effect of Short-Term Genistein Supplementation on the Early Stage in Diabetes-Induced Renal Damage

Kim

Lim

2013

Mediators of Inflammation

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“…The fruit juice prepared from this plant has a hypoglycaemic effect in animals with experimental diabetes and in T2D patients . We recently demonstrated that the aqueous C. ficifolia extract has antioxidant and anti‐inflammatory effects, in addition to a glucose‐lowering effect, in streptozotocin‐induced diabetic mice . Apparently, the hypoglycaemic effect is due to the extract's content of D‐chiro‐inositol (DCI), which is part of the structure of inositol phosphoglycans.…”

Section: Introductionmentioning

confidence: 99%

C ucurbita ficifolia Bouché (Cucurbitaceae) and D-chiro-inositol modulate the redox state and inflammation in 3T3-L1 adipocytes

Fortis-Barrera

Alarcón-Aguilar

Banderas-Dorantes

et al. 2013

Journal of Pharmacy and Pharmacology

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“…The antiglycemic effect of C. ficifolia was seen in patients with type 2 DM with moderate hyperglycemia (7,15,16,18,19). The strongest antiglycemic effect was obtained after three to five hours of oral administration (9). Evidence showed that an aqueous extract of this plant significantly decreased blood sugar and glycosylated hemoglobin.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence showed that an aqueous extract of this plant significantly decreased blood sugar and glycosylated hemoglobin. Another characteristic of C. ficifolia extract is its effect on the distribution and number of pancreatic β cells in the diabetic rats, that is, C. ficifolia intake positively affects the β cell in pancreas (8,9,11). It has been reported that phenols in C. ficifolia can inhibit lipid peroxidation and demonstrate antioxidant activity that also have antiglycemic and antilipemic properties.…”

Section: Discussionmentioning

confidence: 99%

Effects of Cucurbita ficifolia Intake on Type 2 Diabetes: Review of Current Evidences

et al. 2014

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Context: Type 2 diabetes mellitus (DM) is one of the most common chronic diseases worldwide. In recent years, Cucurbita ficifolia intake has been identified as one of the most widely used herbal medications in treatment of DM. Since previous studies have suggested the benefits of C. ficifolia intake in treatment of DM, we reviewed available literature concerning effects of C. ficifolia on Type 2 DM. Evidence Acquisition: Databases such as PubMed, Scopus, and Google scholar were searched. Key words included type 2 diabetes, blood glucose, hyperglycemia, insulin resistance, and C ucurbita . After removing irrelevant article, ten articles were reviewed. Results: Studies reported beneficial effects of C. ficifolia on serum insulin and glucose level. Some of the studies showed a correlation between low level of lipid profiles and plasma glucose and increase intake of C. ficifolia . Although the exact role of C. ficifolia intake on DM has not been identified, the benefits might be due to the effects of active compounds such as flavonoids, alkaloids, polyphenolic components, glutathione peroxidase, and superoxide dismutase. Conclusions: Cucurbita ficifolia intake might have useful effects on prevention and treatment of DM. C ucurbita ficifolia has beneficial effects on insulin sensitivity and risk factors of DM; however, due to the small number of available studies, more researches are needed in this field.Keywords: Type II diabetes; Cucurbita; Hyperinsulinism; Hyperglycemia Copyright © 2014, Shiraz University of Medical Sciences; Published by DOCS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ContextDiabetes mellitus (DM) is a chronic disorder of carbohydrate, fat, and protein metabolism (1). This disease is characterized by high levels of blood glucose due to absence of insulin secretion or insulin resistance (2). Type 2 DM is due to decrease peripheral glucose uptake and increase blood glucose level. Since type 2 DM causes serious nervous system, renal, and ophthalmologic complications, its prevention and treatment has urgent priority. The prevalence of Type 2 DM is predicted to increase dramatically in the next few years. DM affects approximately 4% of the population worldwide and is expected to increase by 5.4% in 2025 (3). Moreover, DM is one of most common chronic disease in Iran. Its prevalence is 7% and 8% among Isfahan and Tehran residents, respectively (3).Traditional medicine is considered in treatment of numerous diseases, especially chronic diseases. Recent researches have shown the beneficial effects of herbs such as vegetable in the treatment of DM. In Asia, traditional medicinal plant, Cucurbita ficifolia (Cucurbitaceae), popularly known as pumpkin, is one of the most widely used herbal medications in treatment of DM (4) . In recent years, C. ficifolia intake is commonly used as antidiabetic and antihyperglycemic agent in ...

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Effect of an aqueous extract of Cucurbita ficifolia Bouché on the glutathione redox cycle in mice with STZ-induced diabetes

Cited by 43 publications

References 41 publications

Protective Effect of Short-Term Genistein Supplementation on the Early Stage in Diabetes-Induced Renal Damage

Protective Effect of Short-Term Genistein Supplementation on the Early Stage in Diabetes-Induced Renal Damage

C ucurbita ficifolia Bouché (Cucurbitaceae) and D-chiro-inositol modulate the redox state and inflammation in 3T3-L1 adipocytes

Effects of Cucurbita ficifolia Intake on Type 2 Diabetes: Review of Current Evidences

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