Effect of an avocado oil-enhanced diet ( Persea americana ) on sucrose-induced insulin resistance in Wistar rats

Abstract

A number of studies have been conducted to evaluate the effects of vegetable oils with varying percentages of monounsaturated and polyunsaturated fatty acids on insulin resistance. However, there is no report on the effect of avocado oil on this pathologic condition. The aim of this work was to evaluate the effect of avocado oil on sucrose-induced insulin resistance in Wistar rats. An experimental study was carried out on Wistar rats that were randomly assigned into six groups. Each group received a different diet over an 8-week period (n = 11 in each group): the control group was given a standard diet, and the other five groups were given the standard feed plus sucrose with the addition of avocado oil at 0%, 5%, 10%, 20%, and 30%, respectively. Variables were compared using Student t test and analysis of variance. Statistically significant difference was considered when p < 0.05. Rats that were given diets with 10% and 20% avocado oil showed lower insulin resistance (p = 0.022 and p = 0.024, respectively). Similar insulin resistance responses were observed in the control and 30% avocado oil addition groups (p = 0.85). Addition of 5-30% avocado oil lowered high sucrose diet-induced body weight gain in Wistar rats. It was thus concluded that glucose tolerance and insulin resistance induced by high sucrose diet in Wistar rats can be reduced by the dietary addition of 5-20% avocado oil.

Avocado oil characteristics of Mexican creole genotypes

“…The lipid‐soluble bioactive substances in avocado contribute to growth inhibition of the human prostate cancer cell lines thereby exhibiting anticancer activities resulting from p27 down‐regulation and cell cycle arrest . Moreover, addition of 5–20% avocado oil reduced glucose tolerance and insulin resistance induced by high sucrose diet in Wistar rats . Phytochemicals in chloroform extract of California Hass avocado fruit induced apoptosis in premalignant and malignant human oral epithelial cell lines via the FADD pathway .…”

Ginger and avocado as nutraceuticals for obesity and its comorbidities

“…Supplementation with hydroalcoholic extracts of the fruit (100‐mg/kg body weight) for 12 weeks reduced weight gain (24.77%) and BMI (17.92%) in rats fed a high‐fat diet (Padmanabhan & Arumugam, ). Body weight reduction and improved insulin sensitivity were observed in rats fed a sucrose‐rich diet and supplemented with 10–30% avocado oil for 8 weeks (Del Toro‐Equihua, Velasco‐Rodriguez, Lopez‐Ascencio, & Vasquez, ). Animals pretreated with an aqueous extract of avocado (100 and 200 mg/kg) for 7 days were protected against CCL4‐induced hepatic toxicity, as it reduced the activity of the liver enzymes aspartate aminotransferase and serum alanine aminotransferase and decreased serum bilirubin levels (Brai et al, ).…”

Palta: compuestos bioactivos y sus potenciales beneficios en salud

“…No hubo diferencias significativas en relación a la ganancia de peso corporal, pero sí hubo una menor ganancia de peso en función de un mayor aporte de aceite de palta 9 . Por otro lado, el área bajo la curva del aumento de intolerancia a la glucosa fue menor en el grupo con la dieta estándar + sacarosa + 5% aceite de palta, con respecto al grupo con la dieta estándar + sacarosa 31 . El extracto acuoso de semilla de palta también tendría actividad hipoglicémica y protectora tisular en páncreas, hígado y riñones en ratas Wistar albinas 10 .…”