Effect of an exercise training intervention with resistance bands on blood cell counts during chemotherapy for lung cancer: a pilot randomized controlled trial

Karvinen, Kristina H.; Esposito, David; Raedeke, Thomas D.; Vick, Joshua Reid; Walker, Paul R.

doi:10.1186/2193-1801-3-15

Cited by 20 publications

(13 citation statements)

References 31 publications

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“…103 A 2013 study showed that Tai Chi in lung cancer patients (after resection) altered the ratio of interferon-producing CD 3 to IL-4producing CD 3 . 104 Karvinen et al 105 showed that exercise training may attenuate leukopenia associated with chemotherapy in NSCLC therapy.…”

Section: How Does Activity Help?mentioning

confidence: 99%

Increasing Physical Activity and Exercise in Lung Cancer: Reviewing Safety, Benefits, and Application

Bade

Thomas

Scott

et al. 2015

Journal of Thoracic Oncology

112

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Lung cancer continues to be a difficult disease frequently diagnosed in late stages with a high mortality and symptom burden. In part because of frequent lung comorbidity, even lung cancer survivors often remain symptomatic and functionally limited. Though targeted therapy continues to increase treatment options for advanced-stage disease, symptom burden remains high with few therapeutic options. In the last several decades, exercise and physical activity have arisen as therapeutic options for obstructive lung disease and lung cancer. To date, exercise has been shown to reduce symptoms, increase exercise tolerance, improve quality of life, and potentially reduce length of stay and postoperative complications. Multiple small trials have been performed in perioperative non-small-cell lung cancer patients, although fewer studies are available for patients with advanced-stage disease. Despite the increased interest in this subject over the last few years, a validated exercise regimen has not been established for perioperative or advanced-stage disease. Clinicians underutilize exercise and pulmonary rehabilitation as a therapy, in part because of the lack of evidence-based consensus as to how and when to implement increasing physical activity. This review summarizes the existing evidence on exercise in lung cancer patients.

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Section: How Does Activity Help?mentioning

confidence: 99%

Increasing Physical Activity and Exercise in Lung Cancer: Reviewing Safety, Benefits, and Application

Bade

Thomas

Scott

et al. 2015

Journal of Thoracic Oncology

112

View full text Add to dashboard Cite

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“…Conversely, the experimental arm (16 postsurgical patients with NSCLC) who followed a guided 16‐week moderate‐intensity tai chi program (60 minutes per session, three sessions per week) managed to preserve a stable T1‐to‐T2 ratio and cortisol levels . Interestingly, preliminary evidence suggests that chemotherapy‐treated patients with lung cancer who joined exercise sessions using resistance bands managed to maintain white blood cell levels during treatment compared with a control group .…”

Section: Biological Mechanismsmentioning

confidence: 99%

“…In another prospective randomized trial, the control group, including 16 patients with surgically resected NSCLC, experienced a decrease in ratio of IFN-γ-producing CD3+ T [107]. Interestingly, preliminary evidence suggests that chemotherapy-treated patients with lung cancer who joined exercise sessions using resistance bands managed to maintain white blood cell levels during treatment compared with a control group [108].…”

Section: Biological Mechanismsmentioning

confidence: 99%

Physical Activity and Exercise in Lung Cancer Care: Will Promises Be Fulfilled?

Avancini

Sartori

Gkountakos³

et al. 2019

The Oncologist

124

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Lung cancer remains the leading cause of cancer‐related death worldwide. Affected patients frequently experience debilitating disease‐related symptoms, including dyspnea, cough, fatigue, anxiety, depression, insomnia, and pain, despite the progresses achieved in term of treatment efficacy. Physical activity and exercise are nonpharmacological interventions that have been shown to improve fatigue, quality of life, cardiorespiratory fitness, pulmonary function, muscle mass and strength, and psychological status in patients with lung cancer. Moreover, physical fitness levels, especially cardiorespiratory endurance and muscular strength, are demonstrated to be independent predictors of survival. Nevertheless, patients with lung cancer frequently present insufficient levels of physical activity and exercise, and these may contribute to quality of life impairment, reduction in functional capacity with skeletal muscle atrophy or weakness, and worsening of symptoms, particularly dyspnea. The molecular bases underlying the potential impact of exercise on the fitness and treatment outcome of patients with lung cancer are still elusive. Counteracting specific cancer cells’ acquired capabilities (hallmarks of cancer), together with preventing treatment‐induced adverse events, represent main candidate mechanisms. To date, the potential impact of physical activity and exercise in lung cancer remains to be fully appreciated, and no specific exercise guidelines for patients with lung cancer are available. In this article, we perform an in‐depth review of the evidence supporting physical activity and exercise in lung cancer and suggest that integrating this kind of intervention within the framework of a global, multidimensional approach, taking into account also nutritional and psychological aspects, might be the most effective strategy. Implications for Practice Although growing evidence supports the safety and efficacy of exercise in lung cancer, both after surgery and during and after medical treatments, most patients are insufficiently active or sedentary. Engaging in exercise programs is particularly arduous for patients with lung cancer, mainly because of a series of physical and psychosocial disease‐related barriers (including the smoking stigma). A continuous collaboration among oncologists and cancer exercise specialists is urgently needed in order to develop tailored programs based on patients’ needs, preferences, and physical and psychological status. In this regard, benefit of exercise appears to be potentially enhanced when administered as a multidimensional, comprehensive approach to patients’ well‐being.

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“…Further, patients commonly present with high levels of fatigue, physical impairment and develop neutropenia following chemotherapy [91][92][93][94] ], and may mitigate, restore or reverse side-effects associated with chemotherapy, inclusive of reductions in neutropenia onset, duration and severity of nadir (Fig. 4) following proposed improvements in immune function [97][98][99]. Neoadjuvant and adjuvant exercise therefore has the potential to assist patients to receive their full individual and aggregate doses of chemotherapy, and coupled with posttherapy exercise, may promote bone marrow quality [97] and improve patient physical condition to heighten clinical eligibility to receive and tolerate second-line chemotherapy; two clinically meaningful outcomes for advanced prostate cancer patients that are worthy of exploration.…”

Section: Exercise and Chemotherapymentioning

confidence: 99%

“…4) following proposed improvements in immune function [97][98][99]. Neoadjuvant and adjuvant exercise therefore has the potential to assist patients to receive their full individual and aggregate doses of chemotherapy, and coupled with posttherapy exercise, may promote bone marrow quality [97] and improve patient physical condition to heighten clinical eligibility to receive and tolerate second-line chemotherapy; two clinically meaningful outcomes for advanced prostate cancer patients that are worthy of exploration.…”

Section: Exercise and Chemotherapymentioning

confidence: 99%