Effect of an extract of<i>Ganoderma lucidum</i>in men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study

Noguchi, Masanori; Kakuma, Tatsuyuki; Tomiyasu, Katsuro; Kurita, Yoshiko; Kukihara, Hiroko; Konishi, Fumiko; Kumamoto, Shoichiro; Shimizu, Kuniyoshi; Kondo, Ryuichiro; Matsuoka, Kei

doi:10.1111/j.1745-7262.2008.00336.x

Cited by 25 publications

(53 citation statements)

References 18 publications

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“…In addition, IPSS-QOL scores significantly improved (p=0.04) in the 6-mg group compared to placebo. No significant differences were found in urine flow rates between all groups after treatment [25].…”

Section: Ganoderma Lucidumcontrasting

confidence: 45%

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Complementary Alternative Medicine and Therapies for Overactive Bladder Symptoms: Is There Evidence for Benefit?

Arunachalam

Rothschild

2015

Curr Bladder Dysfunct Rep

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Overactive bladder is a complex syndrome that can have a significant symptomatic burden on patients. There are currently treatment options available, although these options may have significant side effects that can further diminish patients' quality of life. The need for effective therapies that have high patient acceptability and compliance has caused many patients to seek complementary alternative forms of treatment. Herbal medications, which are used worldwide, have been shown to positively impact quality of life and provide symptomatic improvement in patients suffering with overactive bladder. Acupuncture has also been demonstrated to provide shortterm relief of overactive bladder symptoms, specifically on quality of life, urgency, and frequency. Homeopathic remedies, though not widely studied, have shown to be effective in the short term for treatment of symptoms related to overactive bladder. These options may be associated with fewer side effects than traditional anti-muscarinic medications and/or surgical interventions. Further research is required to assess the true efficacy of these alternative therapeutic options.

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Section: Ganoderma Lucidumcontrasting

confidence: 45%

“…It has been shown to have strong 5-alpha reductase activity [24,25]. In a doubleblind, placebo-controlled randomized trial by Noguchi, 50 men received either various doses of G. lucidum or placebo over the course of 8 weeks.…”

Section: Ganoderma Lucidummentioning

confidence: 99%

Complementary Alternative Medicine and Therapies for Overactive Bladder Symptoms: Is There Evidence for Benefit?

Arunachalam

Rothschild

2015

Curr Bladder Dysfunct Rep

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“…Twenty studies (64.5%) were rated as low-quality randomized controlled trials (RCTs) (Jadad score f2), and the remaining 11 (35.5%) were rated as moderate-to-high (Jadad score o3). Table 2 presents the characteristics of the 11 moderate to high quality studies [26][27][28][29][30][31][32][33][34][35][36] that were selected for detailed analysis. All 11 of the studies were reported as randomized trials; only one (Study 6) 33 did not describe the method of randomisation.…”

Section: Description Of the Paper Selection Processmentioning

confidence: 99%

“…Five trials fulfilled the criteria of a double-blind study design and provided an appropriate description of the double-blind method (Studies 3, 4, 5, 6 and 11). 27,[31][32][33]35 Only four studies described the dropouts and listed the reasons (Studies 4, 5, 6 and 9). 27,28,32,33 Assessment by the Cochrane's risks of bias assessment Figures 2 and 3 display the proportion and summary of the high, low and unclear risk of bias of 11 studies with Jadad scores o3.…”

Section: Description Of the Paper Selection Processmentioning

confidence: 99%

Efficacy and safety of Chinese herbal medicine for benign prostatic hyperplasia: systematic review of randomized controlled trials

Ho¹,

Lin²,

Lui³

et al. 2013

Asian J Androl

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Chinese herbal medicine is commonly used as a treatment for benign prostatic hyperplasia (BPH), but its efficacy and safety remain to be examined. To compare the efficacy and adverse events of Chinese herbal medicine alone or used adjuvantly with Western medications for BPH. Two independent reviewers searched the major electronic databases for randomized controlled trials comparing Chinese herbal medicine, either in single or adjuvant use with Western medication, with placebo or Western medication. Relevant journals and grey literature were also hand-searched. The outcome measures included changes in urological symptoms, urodynamic measures, prostate volume and adverse events. The frequency of commonly used herbs was also identified. Out of 13 922 identified citations of publications, 31 studies were included. Eleven studies with a Jadad score o3 were selected for meta-analysis. Chinese herbal medicine was superior to Western medication in improving quality of life and reducing prostate volume. The frequency of adverse events in Chinese herbal medicine was similar to that of placebo and less than that of Western medication. The evidence is too weak to support the efficacy of Chinese herbal medicine for BPH due to the poor methodological quality and small number of trials included. The commonly used herbs identified here should provide insights for future clinical practice and research. Larger randomized controlled trials of better quality are needed to truly evaluate the efficacy of Chinese herbal medicine.

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“…Human trials have also been carried out with G. lucidum (Noguchi et al, 2008;Wachtel-Galor et al, 2004;Zhou et al, 2005), Lyophyllum decastes (Ukawa et al, 2007) and Hericium erinaceum (Kawagishi & Zhuang, 2008;Mori et al, 2009); these studies did not report any toxicological effects from consumption of these mushrooms.…”

mentioning

confidence: 97%

Mushrooms and agaritine: A mini-review

Roupas

Keogh

Noakes

et al. 2010

Journal of Functional Foods

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Effect of an extract ofGanoderma lucidumin men with lower urinary tract symptoms: a double-blind, placebo-controlled randomized and dose-ranging study

Abstract: The extract of G. lucidum was well tolerated and an improvement in IPSS was observed. The recommended dose of the extract of G. lucidum is 6 mg in men with LUTS.

Cited by 25 publications

References 18 publications

Complementary Alternative Medicine and Therapies for Overactive Bladder Symptoms: Is There Evidence for Benefit?

Complementary Alternative Medicine and Therapies for Overactive Bladder Symptoms: Is There Evidence for Benefit?

Efficacy and safety of Chinese herbal medicine for benign prostatic hyperplasia: systematic review of randomized controlled trials

Mushrooms and agaritine: A mini-review

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