Effect of an Oat Bran-Rich Supplement on the Metabolic Profile of Overweight Premenopausal Women

Abstract

Background/Aims: A healthy diet is a key factor in the prevention of cardiovascular disease, the leading cause of death for women in industrialized countries. In this regard, soluble fibers may have beneficial effects on the plasma lipoprotein/lipid profile. The objective of the present study was to investigate the plasma lipoprotein/lipid response to dietary fibers in overweight premenopausal women within a randomized controlled trial. Methods: Following a 2-week run-in phase, 34 premenopausal women (age: 22–53 years) were randomly assigned either to the control group (no supplement) or to the treatment group, which received 2 oat bran-enriched muffins per day (28 g/day of oat bran) during 4 weeks. Results: Supplementation with oat bran had a beneficial effect on plasma HDL-C levels. Indeed, compared to the control group (n = 16), a mean increase in plasma HDL-C levels of 11.2% was observed in women eating the oat bran supplement (n = 18) (p = 0.01), whereas the total cholesterol/HDL-C ratio decreased by 7.0% (p = 0.002). Results were similar after adjustment for age, apo E genotype and weight change. Conclusion: These results suggest that oat bran-rich foods have beneficial effect on the metabolic profile of overweight women. Integration of these foods as part of a healthy diet may, therefore, improve the cardiovascular risk profile of women.

β-glucans and their significance for the preparation of functional foods - a review

“…However, some authors (e.g. Brown et al 1999;Keogh et al 2003;Robitaille et al 2005) reported no significant changes in the cholesterol levels after the fibre diet. β-glucans show also positive cardio- (Keogh et al 2003;Stephens 2005) and subsequently glycaemic reactions (Cavallero et al 2002;Tappy 2006;Alminger & Eklund-Jonsson 2008;Nazare et al 2009) beneficial for the overweight humans and patients with type 2 diabetes ).…”

Cereal bran fortified-functional foods for obesity and diabetes management: Triumphs, hurdles and possibilities

“…The subjects received 2 oat branenriched muffins (14 g each) daily for a month. The supplementation improved plasma HDL cholesterol levels, mean being 11.2% (Robitaille, Fontaine-Bisson, Couture, Tchernof, & Vohl, 2005). The effects of oat bran on plasma cholesterol, markers of inflammation, eNOS expression and development of atherosclerosis were examined in mice model.…”

Macronutrients and type 1 diabetes (revision number 6)

“…Fifteen randomised controlled trials in 17 publications were identified that presented evidence on oat bran/oatmeal, barley fibre or β-glucan supplements in relation to energy intake (Whyte et al, 1992;Abrahamsson et al, 1994;Johnston, 1998;Reynolds et al, 2000;Davy et al, 2002a;Davy et al, 2002b;Kerckhoffs et al, 2003;He et al, 2004;Robitaille et al, 2005;Chen et al, 2006;Keenan et al, 2007;Theuwissen & Mensink, 2007;Maki et al, 2007a;Maki et al, 2007b;Smith et al, 2008;Sundberg, 2008;Kohl et al, 2009), twelve of which were included in a meta-analysis (Whyte et al, 1992;Abrahamsson et al, 1994;Reynolds et al, 2000;Davy et al, 2002a;Kerckhoffs et al, 2003;Robitaille et al, 2005;Chen et al, 2006;Theuwissen & Mensink, 2007;Maki et al, 2007a;Maki et al, 2007b;Smith et al, 2008;Sundberg, 2008). Two trials reported energy intake data in two publications (Davy et al, 2002a;Davy et al, 2002b) and (He et al, 2004;Chen et al, 2006).…”