Effect of an Oscillating Magnetic Field on the Release Properties of Magnetic Collagen Gels

Abstract

The paper describes the effect of an oscillating magnetic field (OMF) on the morphology and release properties of collagen gels containing magnetic nanoparticles and microparticles and fluorescent drug analogues. Collagen gels were prepared through fibrillogenesis of collagen in the presence of iron oxide magnetic particles averaging 10 nm or 3 mum in diameter and rhodamine-labeled dextran (Dex-R) of molecular weights between 3000-70 000 g/mol. Dextran molecules effectively simulate protein-based drugs, since they have similar molecular weights and dimensions. The paper discusses the effect of an OMF on the release properties of the gels and proposes an empirical model to predict the release rate. It also demonstrates the self-repair capability of collagen gels following the structural damage caused by an OMF.

On the chemical synthesis and drug delivery response of folate receptor-activated, polyethylene glycol-functionalized magnetite nanoparticles

“…In the presence of magnetic field, the magnetic core constituting the polymer-encapsulated nanoparticle carrier experiences mechanical deformation within the matrix, generating alternating compressive and tensile stresses. This provides a pumping Table 2 Assignment of FTIR spectra of as-synthesized magnetite nanoparticles, PEG-coated magnetite nanoparticles, pure folic acid and folic acid-modified, PEG-coated magnetite nanoparticles mechanism that enables diffusion of the drug out of the polymer shell [46][47][48]. If the PEG shell encapsulating the magnetic core was relatively thick, then the magnitude of modulation and consequent mechanical deformation experienced by the drug-conjugated PEG shell will be significantly reduced.…”

Temperature‐Sensitive Nanocapsules for Controlled Drug Release Caused by Magnetically Triggered Structural Disruption

“…who demonstrated insulin release from a magnetic composite of ethylene vinyl acetate under a low frequency magnetic field. [1][2] Recently, De Paoli et al [3] reported magnetically enhanced dextran release (which simulates protein release) from a magnetic nanocomposite made of a collagen gel. Magnetic biocompatible iron oxide nanoparticles were used in the latter study as in our previous work on ferrogels, [4] but they both involved bulk gels instead of colloids.…”

Magnetic hyaluronate hydrogels: preparation and characterization

“…Magnetic hydrogels have also been produced by filling hydrogels with magnetic particles (e.g. maghemite, magnetite, cobalt-ferrite) [1], this procedure makes them more suitable for certain biomedical applications, such as drug delivery [1,6,7], enzyme immobilization [1,[8][9][10] or cancer therapy by the combination of controlled drug release and magnetic hyperthermia [1,11]. Magnetic hydrogels have been prepared by three, fundamentally different methods: blending, in situ precipitation and grafting-onto methods [1].…”