Effect of an α-Glucosidase Inhibitor (Voglibose), in Combination with Sulphonylureas, on Glycaemic Control in Type 2 Diabetes Patients

Abstract

A multicentre study was conducted to evaluate the effect of the alpha-glucosidase inhibitor, voglibose, on glycaemic control in 113 patients with type 2 diabetes whose blood glucose control was poor on treatment with a sulphonylurea drug. The patients were treated for 24 weeks with 0.6 mg voglibose, given orally three times daily, before a meal, together with their usual sulphonylurea drug treatment. In the 86 patients who completed the study, fasting plasma glucose, 2-h post-prandial plasma glucose and haemoglobin showed statistically significant decreases in FPG, 2h-PPG and HbA1c compared with the baseline (P < 0.05) at almost all time-points during treatment. No serious adverse reactions were reported and there were no significant changes in mean body weights. Plasma glucose control was considered to be improved in 65% of patients; there were no adverse events in 92.9% of patients. The results suggest that the combined use of this alpha-glucosidase inhibitor and sulphonylurea drugs may be effective in controlling plasma glucose in patients with type 2 diabetes and that this combination might delay the onset of vascular complications in these patients.

Health benefits of finger millet (Eleusine coracana L.) polyphenols and dietary fiber: a review

“…They may act as inhibitors of amylase and glucosidase (similar to acarbose, miglitol and voglibose) leading to a reduction in post-prandial hyperglycemia (Bailey 2001). Synergy between phenolics and dietary fiber may play a role in mediating amylase inhibition and therefore, have the potential to contribute to the management of type II Diabetes mellitus (Saito et al 1998;Toeller 1994). Chethan et al (2008a) studied the mode of inhibition of finger millet malt amylases by the millet phenolics and reported that the crude polyphenolic extract exerts mixed non-competitive type inhibition, whereas the individual phenolic compounds isolated from the extract exhibit uncompetitive inhibition.…”

Synthesis of some novel heterocylic compounds derived from 2-[3-(4-chlorophenyl)-5-(4-methoxybenzyl)-4H-1,2,4-triazol-4-yl]acetohydrazide and investigation of their lipase andα-glucosidase inhibition

“…1 H and 13 C NMR spectra were measured on a BRUKER AVANCE II-400 (400 MHz) (Darmstadt, Germany) using DMSO-d 6 as solvent and TMS as internal standard. The elemental analysis was performed on a Costech Elemental Combustion System CHNS-O elemental analyzer (Valencia, CA).…”

“…In the 1 H NMR spectra of these compounds, NH peaks were observed as a singlet at 13.75, 14.02 and 14.07 ppm, respectively 38 . The C ¼ S group resonated at 168.08-169.15 ppm in the 13 C NMR spectra of compounds (3a-c) and so their thionic form was proved 39 . Intramolecular cyclization of the acid hydrazide (1) with carbon disulfide in the presence of potassium hydrtoxide in .…”

“…It is considered as a significant strategy in the management of diabetes mellitus if the a-glucosidase inhibitors are used. For example, in the treatment of diabetes mellitus patients, some a-glucosidase inhibitors, such as acarbose and voglibose, are extensively used but often causes severe gastrointestinal side effects such as flatulence and diarrhea [11][12][13] . Heterocyclic compounds containing 1,2,4-triazole skeleton are known to possess a wide range of pharmacological activities such as antimicrobial, antitubercular, anti-inflammatory, antiviral, antioxidant, antidepressant, anticonvulsant, antimalarial, anti-diabetic, anti-obesity, enzyme inhibitory and anticancer activities [14][15][16][17] .…”

“…The signal due to the N-CH 3 (for 4a-c and 6a) protons appeared at 5.50-5.52 ppm 43,44 . The signals due to the N-CH 2 -N and C ¼ S carbons appeared at 68.30-70.06 and 168.95-178.27 ppm in the 13 C NMR, respectively 43,44 .…”