Effect of anabolic steroids on platelet proliferation

Сергеев, П. В.; Semeikin, A. V.; Dukhanin, A. S.; Соловьева, Е. В.

doi:10.1007/bf00841369

Cited by 4 publications

(7 citation statements)

References 1 publication

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“…An another work [34] presented similar findings: two anabolic steroids, the testosterone (32) and methandrostenolone (36) decreased mass, the quality of DNA and the incorporation of 3 H labeled thymidine in thymocytes after ten-days injection to mice in 5 mg/100 g dose. Ecdysten ® (preparation containing various ecdysteroids) did not influence proliferative activity of thymocytes in vitro and thymolytic effect in vivo.…”

Section: Hormonal Activity On Mammalssupporting

confidence: 53%

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Phytoecdysteroids and Anabolic-Androgenic Steroids - Structure and Effects on Humans

Báthori¹,

Tóth²,

Hunyadi³

et al. 2008

CMC

172

168

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Phytoecdysteroids are structural analogs of the insect molting hormone ecdysone. Plants comprise rich sources of ecdysteroids in high concentration and with broad structural diversity. Ecdysteroids have a number of proven beneficial effects on mammals but the hormonal effects of ecdysteroids have been proven only in arthropods. Their structures are somewhat similar to those of the vertebrate steroid hormones but there are several structural differences between the two steroid groups. Despite of these essential structural differences, ecdysteroids exert numerous effects in vertebrates that are similar to those of vertebrate hormonal steroids, and they may serve as effective anabolic, hepatoprotective, immunoprotective, antioxidant and hypoglycemic agents.Ecdysteroids do not bind to the cytosolic steroid receptors, instead, they are likely to influence signal transduction pathways, like the anabolic steroids, possibly via membrane bound receptors.The application of phytoecdysteroids is a promising alternative to the use of anabolic-androgenic steroids because of the apparent lack of adverse effects. The prospective use of phytoecdysteroids may extend to treatments of pathological conditions where anabolic steroids are routinely applied. One of the most cited aspects of phytoecdysteroid application (on the Internet) is the increase of muscle size. However in this field too stringent research is needed as an adequate cytological explanation is not yet available for the anabolic. This paper reports on the most important structural differences between androgenic hormones, their synthetic analogs and ecdysteroids. The anabolic/hormonal effects and the possible mechanisms of action of these compounds are also discussed as concerns the skeletal muscle.

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Section: Hormonal Activity On Mammalssupporting

confidence: 53%

“…This conclusion was based on measurement of the in-crease of the prostate and seminal vesicle mass, where no androgenic effect was observed [31][32][33][34].…”

Section: Hormonal Activity On Mammalsmentioning

confidence: 99%

Phytoecdysteroids and Anabolic-Androgenic Steroids - Structure and Effects on Humans

Báthori¹,

Tóth²,

Hunyadi³

et al. 2008

CMC

172

168

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“…The whole side chain of the precursor sterols is generally kept in the case of ecdysteroids, and this is the way the C 27 -C 2 9 ecdysteroids are generated. Cleavage of the side chain gives C 19 , C 21 and C 24 ecdysteroids whose biosynthesis is similar to that of the class of pregnanes, 5β-androstanes and bile acids. Anellations of the rings are characteristic: C/D is trans, and A/B is generally cis.…”

Section: Chemical Structure Of Ecdysteroidsmentioning

confidence: 98%

“…Sergeev et al [19] compared the results of thymolytic tests after treating the mice with the same daily dose (50 µg/kg) of 20-hydroxyecdysone and testosterone for ten days. Administration of testosterone caused thymolytic positive side effects, while the results for 20-hydroxyecdysone were negative.…”

Section: Anabolic Effect Of Ecdysteroidsmentioning

confidence: 99%

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Phytoecdysteroids - From Isolation to Their Effects on Humans

Báthori¹,

Pongrácz

2005

CMC

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An overview is given on both well-known and recently discovered phytoecdyteroids including a sophisticated isolation scheme and notable physiological and pharmacological effects of ecdysteroids on vertebrates. The isolation of pure ecdysteroids has been improved by the use of low-pressure reversed-phase chromatography. An optimized combination of preliminary purification and chromatographic separations results in pure ecdysteroids. Structural elucidation has been done using spectroscopic methods, however, the final proof of the steric structure is rendered using x-ray crystallography. Ecdysteroid containing preparations show a boom and both OTC products and numerous preparation techniques can be found using the Internet. This paper will give a review on the kaleidoscope of pharmacological effects attributed to the ecdysteroids, such as: An increase of protein synthesis (for body-building, AIDS, patients with neoplasm disease, etc.), and other body functions; Antidepressant effect; Shielding the body from stress, and improve the physical and sexual performance; Prevention from infections and certain diseases. A list of recent offers of ecdysteroid-containing products will also be given. The perspective use of ecdysteroids is promising in genetics. Steroid regulation of programmed cell death during development and differentiation has recently come to the limelight. Murine model of human diseases and its influencing with ecdysteroids are detailed.

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Membranotropic effects of glucocorticoids. Effect of hydrocortisone on D-glucose uptake by isolated hepatocytes

Ogurtsov

Dukhanin

2000

Bull Exp Biol Med

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Hydrocortisone immobilized on polyvinylpyrrolidone did not affect D-glucose uptake by hepatocytes, while free hydrocortisone in a concentration of 10 ~tM or higher decreased the initial rate of this process. Hydrocortisone-induced inhibition was dose-dependent and related to a decrease in the maximum rate of D-glucose uptake. Polyvinylpyrrolidone-immobilized hydrocortisone potentiated the effects of free hormone. Membranotropic effect of hydrocortisone on D-glucose transport into hepatocytes was associated with a decreased number of glucose carrier molecules or their turnover, rather than with lowered affinity of transport systems for glucose.

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Effect of anabolic steroids on platelet proliferation

Cited by 4 publications

References 1 publication

Phytoecdysteroids and Anabolic-Androgenic Steroids - Structure and Effects on Humans

Phytoecdysteroids and Anabolic-Androgenic Steroids - Structure and Effects on Humans

Phytoecdysteroids - From Isolation to Their Effects on Humans

Membranotropic effects of glucocorticoids. Effect of hydrocortisone on D-glucose uptake by isolated hepatocytes

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