Effect of Anatomical Irregularities on the Dose in Electron Beam Therapy

Karjalainen, Pertti T.; Brenner, M.; Rytilä, A

doi:10.3109/02841866809133186

Cited by 5 publications

(1 citation statement)

References 2 publications

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“…The MC dose calculation algorithm [4][5][6] is deemed to be the most accurate and robust absorbed dose calculation tool in radiation therapy that can be used for radiation treatment planning in heterogeneous patient anatomy volumes. [7][8][9][10][11] It can provide an accurate representation of radiation beams produced by the treatment unit provided that it has been commissioned properly. MC transport simulations can handle multiple scattering of electrons across tissue interfaces more accurately than any of the currently used analytical dose calculation algorithms.…”

Section: Introductionmentioning

confidence: 99%

Monte Carlo electron source model validation for an Elekta Precise linac

et al. 2011

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Percentage depth dose and beam profile data were in most cases within a tolerance of 2%/2 mm. The biggest discrepancies were in most cases recorded in the first 6 mm of the water phantom. Circular fields showed local dose agreement within 3%/3mm. Good agreement was found between calculated dose distributions for a paranasal sinus case between Monte Carlo, film measurements and a CMS XiO treatment planning system. The electron beam model can be easily implemented in the BEAMnrc or DOSXYZnrc Monte Carlo codes enabling quick calculation of electron dose distributions in complex geometries.

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Section: Introductionmentioning

confidence: 99%

Monte Carlo electron source model validation for an Elekta Precise linac

et al. 2011

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Optimization of 3D conformal electron beam therapy in inhomogeneous media by concomitant fluence and energy modulation

et al. 1997

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The possibilities of using simultaneous fluence and energy modulation techniques in electron beam therapy to shape the dose distribution and almost eliminate the influences of tissue inhomogeneities have been investigated. By using a radiobiologically based optimization algorithm the radiobiological properties of the tissues can be taken into account when trying to find the best possible dose delivery. First water phantoms with differently shaped surfaces were used to study the effect of surface irregularities. We also studied water phantoms with internal inhomogeneities consisting of air or cortical bone. It was possible to improve substantially the dose distribution by fluence modulation in these cases. In addition to the fluence modulation the most suitable single electron energy in each case was also determined. Finally, the simultaneous use of several preselected electron beam energies was also tested, each with an individually optimized fluence profile. One to six electron energies were used, resulting in a slow improvement in complication-free cure with increasing number of beam energies. To apply these techniques to a more clinically relevant situation a post-operative breast cancer patient was studied. For simplicity this patient was treated with only one anterior beam portal to clearly illustrate the effect of inhomogeneities like bone and lung on the dose distribution. It is shown that by using fluence modulation the influence of dose inhomogeneities can be significantly reduced. When two or more electron beam energies with individually optimized fluence profiles are used the dose conformality to the internal target volume is further increased, particularly for targets with complex shapes.

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