Effect of Androgen on the Sebaceous Glands of Human Skin

Rony, Hugo R.

doi:10.1001/archderm.1943.01510060025002

Cited by 61 publications

(5 citation statements)

References 2 publications

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“…First, the meibomian gland is a large sebaceous gland, and androgens are known to control the development, differentiation and lipid production of sebaceous glands throughout the body 44–62. Androgens appear to act primarily on acinar epithelial cells in sebaceous glands, and these cells contain androgen receptor mRNA, as well as androgen receptor protein in their nuclei.…”

Section: Androgen Influence On Meibomian Gland Functionmentioning

confidence: 99%

Androgen Deficiency, Meibomian Gland Dysfunction, and Evaporative Dry Eye

Sullivan

Evans

et al. 2002

Annals of the New York Academy of Sciences

287

148

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Section: Androgen Influence On Meibomian Gland Functionmentioning

confidence: 99%

Androgen Deficiency, Meibomian Gland Dysfunction, and Evaporative Dry Eye

Sullivan

Evans

et al. 2002

Annals of the New York Academy of Sciences

287

148

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“…Hamilton [111] showed that castrated males who had no acne could develop the disease after administration of testosterone. Two years later, Rony and Zakon [112] demonstrated that prepubertal boys treated with testosterone experienced enlargement of their sebaceous glands.…”

Section: Seborrhea and Acne: Inseparable Players Of The Pathogenic Prmentioning

confidence: 99%

Acne Pathogenesis: History of Concepts

Tilles¹

2014

Dermatology

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From the first reliable descriptions of acne in the early 19th century, dermatologists recognized it as a disease of the pilosebaceous follicle. Until the middle of the 20th century, they hypothesized that seborrhoea, follicular keratosis and microorganisms could be individually responsible for the acne lesions. Inflammation was only regarded as the final and inescapable step of the acne process. Although the importance of these factors has been reevaluated, recent works still regarded them as mandatory. In the 1970s, the onset of isotretinoin dramatically improved acne management. It also provided great opportunities for a better understanding of the pathogenic factors of acne. This study analyzes their genesis and development from the seminal contributions until recent advances.

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“…Administration of testosterone, dehydroepiandrosterone, and androstenedione have been shown to increase sebum production and the size of sebaceous glands. 9 , 10 Acne flares are also seen during periods of stress, which is also a state of increased adrenal androgens. Interestingly, castrated male patients, those without testicular androgens, and those with androgen receptor defects are not afflicted with acne.…”

Section: Physiology/basic Science Rationalementioning

confidence: 99%

Examining the use of oral contraceptives in the management of acne

Salvaggio¹,

Zaenglein²

2010

IJWH

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Combined oral contraceptive pills (cOCPs) are often used in the treatment of acne in females. They are effective, safe, and easy to use in appropriate patients in combination with more conventional acne therapies. This article will briefly address the physiologic rationale for the use of cOCPs in the treatment of acne. It will also review efficacy by examining relevant clinical trials. Safety considerations and the adverse event profile for oral contraceptives will be presented. Finally, practical considerations for prescribing cOCPs will be discussed.

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Effect of Androgen on the Sebaceous Glands of Human Skin

Cited by 61 publications

References 2 publications

Androgen Deficiency, Meibomian Gland Dysfunction, and Evaporative Dry Eye

Androgen Deficiency, Meibomian Gland Dysfunction, and Evaporative Dry Eye

Acne Pathogenesis: History of Concepts

Examining the use of oral contraceptives in the management of acne

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