Effect of Anemia on Mortality in Mechanically Ventilated Patients With Chronic Obstructive Pulmonary Disease

Gadre, Shruti; Jhand, Aravdeep; Abuqayyas, Sami; Wang, Xiaofeng; Guzmán, Jorge; Duggal, Abhijit

doi:10.1177/0885066617739561

Cited by 7 publications

(14 citation statements)

References 26 publications

(25 reference statements)

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“…However, there is no consensus on whether this standard is clinically relevant in COPD patients . In the current study, standards for diagnostic criteria (hemoglobin level <120 g/L for both men and women) for anemia in COPD patients requiring IMV were based on published literature …”

Section: Discussionsupporting

confidence: 89%

“…In our study, the 90‐day all‐cause mortality rate was 33.9% (38/112). However, Rasmussen et al reported that 90‐day mortality in COPD patients requiring IMV was 35.1% (78/222). Gadre et al reported that 90‐day mortality in COPD patients requiring IMV was 43.0% (476/1107), and that hospital mortality in COPD patients requiring IMV was 30% (204/670) .…”

Section: Discussionmentioning

confidence: 99%

“…Applying hemoglobin <120 g/L as the diagnostic criterion, the incidence of anemia in the patient population in the current study was 45.5% (51/112). Previous reports have estimated the incidence of anemia (hemoglobin <120 g/L) at 18%‐79.9% in COPD patients requiring IMV . Many studies have shown that anemia affects the prognosis of AECOPD patients, especially when the patient requires mechanical ventilation (IMV or NIV) …”

Section: Discussionmentioning

confidence: 99%

“…ARF was defined as an acute failure to maintain adequate gas exchange and was characterized by abnormalities in arterial blood gas tensions (PaO 2 < 60mmHg, with or without PaCO 2 > 45 mmHg) while breathing room air . Anemia was defined as a hemoglobin level < 120 g/L for both men and women based on the published literature …”

Section: Methodsmentioning

confidence: 99%

“…Some studies have identified acidaemia as a potential predictor, while other studies have not . Notably, in the prognostic model of AECOPD combined with ARF, anemia (a comorbidity of severe COPD) was shown to have a greater impact on patient outcomes than acidaemia, and published reports indicate that anemia may be associated with increased mortality among COPD patients requiring IMV …”

Section: Introductionmentioning

confidence: 99%

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The v‐DECAF score can predict 90‐day all‐cause mortality in patients with COPD exacerbation requiring invasive mechanical ventilation

Shi

Sheng

Nian

et al. 2019

Clinical Respiratory J

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Introduction The DECAF score is a simple and effective tool for predicting mortality in patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease (AECOPD); however, the DECAF score has not been validated in AECOPD patients requiring invasive mechanical ventilation (IMV). We devised the ventilator (v)‐DECAF score, in which “anemia” replaces “acidaemia,” for use in AECOPD patients requiring IMV. The objective of this study was to compare the predictive efficacy of the v‐DECAF score and the DECAF score. Methods This study prospectively recruited 112 consecutive AECOPD patients requiring IMV from a single center. The clinical endpoint was 90‐day all‐cause mortality. Demographic and clinical data were recorded, as well as APACHE II, GCS, CURB‐65, BAP‐65 and DECAF scores, and the newly devised v‐DECAF score. The discriminatory value of the scoring systems in predicting 90‐day all‐cause mortality was determined using the area under the receiver operating characteristic (AUROC) curve. Results In multivariate logistic regression analysis, the v‐DECAF score was an independent predictor of 90‐day all‐cause mortality (odds ratio 3.004, 95% CI 1.658‐5.445, P < 0.001). The AUROC of the v‐DECAF and DECAF scores were 0.852 (95% CI 0.766‐0.938) and 0.777 (95%CI: 0.676‐0.878), respectively. The v‐DECAF score had a better predictive value for 90‐day all‐cause mortality compared to the DECAF score (Z = 2.338, P = 0.019). Conclusion The v‐DECAF score had good discriminatory power in predicting 90‐day all‐cause mortality in AECOPD patients requiring IMV.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%