Effect of Angelica keiskei Koidzumi Extract on Alcohol-Induced Hepatotoxicity In Vitro and In Vivo

Lee, Yoo‐Hyun; An, Yeon Ju; Kim, Ji Won; Choi, Hyo‐Kyoung; Yoo-Hyun, Lee

doi:10.3746/jkfn.2016.45.10.1391

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…1 ). Treatment with an Angelica keiskei Koidzumi leaf extract containing a large amount of quercetin-based compounds increased the expression of antioxidant enzymes reduced by ethanol, suppressing ethanol-induced oxidative stress [ 45 ]. Quercetin derivatives, luteolin, protocatechuic acid, and various phenolic compounds and chalcones protect against oxidative stress, a major factor in alcohol-induced hepatocellular damage [ 46 47 48 49 ].…”

Section: Discussionmentioning

confidence: 99%

Aqueous extract ofLaurus nobilisleaf accelerates the alcohol metabolism and prevents liver damage in single-ethanol binge rats

Jung,

Choi,

Kim

et al. 2023

Nutr Res Pract

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BACKGROUND/OBJECTIVES Excessive alcohol consumption has harmful health effects, including alcohol hangovers and alcohol-related liver disease. Therefore, methods to accelerate the alcohol metabolism are needed. Laurus nobilis is a spice, flavoring agent, and traditional herbal medicine against various diseases. This study examined whether the standardized aqueous extract of L. nobilis leaves (LN) accelerates the alcohol metabolism and protects against liver damage in single-ethanol binge Sprague-Dawley (SD) rats. MATERIALS/METHODS LN was administered orally to SD rats 1 h before ethanol administration (3 g/kg body weight [BW]) at 100 and 300 mg/kg BW. Blood samples were collected 0.5, 1, 2, and 4 h after ethanol administration. The livers were excised 1 h after ethanol administration to determine the hepatic enzyme activity. The alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activities in the liver tissue were measured. RESULTS LN decreased the serum ethanol and acetaldehyde levels in ethanol-administered rats. LN increased the hepatic ADH and ALDH activities but decreased the alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transferase activities in the ethanol-administered rats. In addition, LN inhibited lipid peroxidation and increased the activities of SOD and GPx. CONCLUSIONS LN modulates the mediators of various etiological effects of excessive alcohol consumption and enhances the alcohol metabolism and antioxidant activity, making it a potential candidate for hangover treatments.

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Section: Discussionmentioning

confidence: 99%

Aqueous extract ofLaurus nobilisleaf accelerates the alcohol metabolism and prevents liver damage in single-ethanol binge rats

Jung,

Choi,

Kim

et al. 2023

Nutr Res Pract

View full text Add to dashboard Cite

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The Role of Oxidative Stress in Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Preclinical Studies

Rabelo,

Andrade,

Costa

2024

Nutrients

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Alcoholic Fatty Liver Disease (AFLD) is characterized by the accumulation of lipids in liver cells owing to the metabolism of ethanol. This process leads to a decrease in the NAD+/NADH ratio and the generation of reactive oxygen species. A systematic review and meta-analysis were conducted to investigate the role of oxidative stress in AFLD. A total of 201 eligible manuscripts were included, which revealed that animals with AFLD exhibited elevated expression of CYP2E1, decreased enzymatic activity of antioxidant enzymes, and reduced levels of the transcription factor Nrf2, which plays a pivotal role in the synthesis of antioxidant enzymes. Furthermore, animals with AFLD exhibited increased levels of lipid peroxidation markers and carbonylated proteins, collectively contributing to a weakened antioxidant defense and increased oxidative damage. The liver damage in AFLD was supported by significantly higher activity of alanine and aspartate aminotransferase enzymes. Moreover, animals with AFLD had increased levels of triacylglycerol in the serum and liver, likely due to reduced fatty acid metabolism caused by decreased PPAR-α expression, which is responsible for fatty acid oxidation, and increased expression of SREBP-1c, which is involved in fatty acid synthesis. With regard to inflammation, animals with AFLD exhibited elevated levels of pro-inflammatory cytokines, including TNF-a, IL-1β, and IL-6. The heightened oxidative stress, along with inflammation, led to an upregulation of cell death markers, such as caspase-3, and an increased Bax/Bcl-2 ratio. Overall, the findings of the review and meta-analysis indicate that ethanol metabolism reduces important markers of antioxidant defense while increasing inflammatory and apoptotic markers, thereby contributing to the development of AFLD.

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Effect of Angelica keiskei Koidzumi Extract on Alcohol-Induced Hepatotoxicity In Vitro and In Vivo

Cited by 2 publications

References 17 publications

Aqueous extract ofLaurus nobilisleaf accelerates the alcohol metabolism and prevents liver damage in single-ethanol binge rats

Aqueous extract ofLaurus nobilisleaf accelerates the alcohol metabolism and prevents liver damage in single-ethanol binge rats

The Role of Oxidative Stress in Alcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Preclinical Studies

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