Effect of angiotensin II type 1 receptor blockade on kidney ischemia/reperfusion; a gender-related difference

Moslemi, Fatemeh; Taheri, Pegah; Azimipoor, Mahdis; Ramtin, Sina; Hashemianfar, Mostafa; Momeni-Ashjerdi, Ali; Eshraghi-Jazi, Fatemeh; Talebi, Ardeshir; Nasri, Hamid; Nematbakhsh, Mehdi

doi:10.15171/jrip.2016.29

Cited by 9 publications

(9 citation statements)

References 27 publications

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“…When it comes from ischemia/reperfusion the observations are not consistent. Studies conducted in Wistar rats have found that functional and structural injuries induced by ischemia/reperfusion are worsen in the male than female 43 – 46 , similar between female and male 47 , 48 , or even worsen in female than male rats 49 , 50 , and these results differ to that occurs in mice in which the females are more resistant to IR injury 39 . Using renal function (creatinine clearance and renal blood flow), and tubular injury markers (proteinuria, injured tubules %, and urinary excretion of Hsp72), we found, that after 24-h of renal bilateral ischemia, female and male rats displayed the same magnitude of IRI.…”

Section: Discussionmentioning

confidence: 93%

Gender Differences in the Acute Kidney Injury to Chronic Kidney Disease Transition

Lima‐Posada

Portas-Cortés

Pérez‐Villalva

et al. 2017

Sci Rep

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This study evaluated if there is a sexual dimorphism in the acute kidney injury (AKI) to chronic kidney disease (CKD) transition and the time-course of the potential mechanisms involved in the dimorphic response. Female and male rats were divided into sham-operated or underwent 45-min renal ischemia (F + IR, and M + IR). All groups were studied at 24-h and 1, 2, 3, or 4-months post-ischemia. Additionally, oophorectomized rats were divided into sham or IR groups. After 24-h, AKI extent was simllar in females and males, but female rats exhibited less oxidative stress and increased renal GSH content. After 4-months and despite similar AKI, the M + IR group developed CKD characterized by proteinuria, tubulointerstitial fibrosis, glomerular hypertrophy, increased oxidative stress and a reduction in HIF1α and VEGF from the 1st-month and persisting throughout the time-course studied. Interestingly, the F + IR group did not develop CKD due to lesser oxidative stress and increased eNOS, TGFβ and HIF1α mRNA levels from the 1st-month after IR. Whereas, oophorectomized rats did develop CKD. We found a sexual dimorphic response in the AKI to CKD transition. Early antioxidant defense and higher TGFβ, HIF1α and eNOS were among the renoprotective mechanisms that the F + IR group demonstrated.

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Section: Discussionmentioning

confidence: 93%

Gender Differences in the Acute Kidney Injury to Chronic Kidney Disease Transition

Lima‐Posada

Portas-Cortés

Pérez‐Villalva

et al. 2017

Sci Rep

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“…Some clinical and experimental animal studies have found evidence for the upregulation of RAS system in the progression of renal disease,[1011] and AT1R blockade may improve impaired kidney. [612] The effects of losartan through decreasing of inflammation, blood pressure, platelet activation and aggregation, and increasing of vasodilation and glomerular filtration rate (GFR) have been reported. [131415] In the present study, we showed the effects of losartan on renal function in 4/6 nephroctomized male and female rats, and the major findings indicated that losartan increased Cr clearance and UF in both genders; however, it was significant only in male rats.…”

Section: Discussionmentioning

confidence: 99%

Protective role of angiotensin Type 1 receptor blockade in 4/6 nephrectomized male and female rats

Moeini

Talebi

Nematbakhsh³

2019

Int J Prev Med

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Background: Chronic kidney disease associated with serious morbidity and mortality rate while it is affected by renin-angiotensin system. The effects of losartan as angiotensin II Type 1 receptor antagonist on renal functional in 4/6 nephrectomized rats was evaluated. Methods: Twenty-six male and female Wistar rats underwent 4/6 nephrectomy, and the animals from each gender were randomly divided into two groups which treated with vehicle and losartan (10 mg/kg/day for 1 week). The parameters related to kidney function were measured. Results: Creatinine (Cr) clearance and urine flow were improved in losartan-treated group significantly ( P < 0.05). The serum level of blood urea nitrogen and Cr and kidney tissue damage score and sodium urinary output (U Na V) did not alter. However, losartan decreased percentage of sodium excretion (E Na %) in both genders insignificantly. Conclusions: Losartan may improve renal function in 4/6 nephrectomized male rats.

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“…AT1R belongs to a family of seven transmembrane G protein-coupled receptors (GPCR) and regulate most of the physiological activities of Ang II in various kinds of target cells (Moslemi et al, 2016 ). AT1R plays a predominant role in the control of AngII-induced vascular functions.…”

Section: Structural Characteristics and Physiological Functions Of Bkmentioning

confidence: 99%

Molecular Mechanisms Underlying Renin-Angiotensin-Aldosterone System Mediated Regulation of BK Channels

2017

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Large-conductance calcium-activated potassium channels (BK channels) belong to a family of Ca2+-sensitive voltage-dependent potassium channels and play a vital role in various physiological activities in the human body. The renin-angiotensin-aldosterone system is acknowledged as being vital in the body's hormone system and plays a fundamental role in the maintenance of water and electrolyte balance and blood pressure regulation. There is growing evidence that the renin-angiotensin-aldosterone system has profound influences on the expression and bioactivity of BK channels. In this review, we focus on the molecular mechanisms underlying the regulation of BK channels mediated by the renin-angiotensin-aldosterone system and its potential as a target for clinical drugs.

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Effect of angiotensin II type 1 receptor blockade on kidney ischemia/reperfusion; a gender-related difference

Cited by 9 publications

References 27 publications

Gender Differences in the Acute Kidney Injury to Chronic Kidney Disease Transition

Gender Differences in the Acute Kidney Injury to Chronic Kidney Disease Transition

Protective role of angiotensin Type 1 receptor blockade in 4/6 nephrectomized male and female rats

Molecular Mechanisms Underlying Renin-Angiotensin-Aldosterone System Mediated Regulation of BK Channels

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