1962
DOI: 10.1161/01.res.10.5.807
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Effect of Angiotensin Infusion on Regional Blood Flow and Regional Vascular Resistance in the Rat

Abstract: "4 have been comprehensively reviewed by Page and Bumpus. 5 Although the literature is replete with information on its overall pressor properties and its effects on the cardiac output, the effects of angiotensin on regional blood flow and organ vascular resistance have not been adequately evaluated for most regions. Observations on the regional effects of angiotensin have been confined to a few organs or areas. As will be shown in the Discussion, the results are not always consistent in different preparations,… Show more

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Cited by 67 publications
(20 citation statements)
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“…In rats, infusion of angiotensin reduces renal blood flow and increases vascular resistance; indeed, the kidney is the only organ in this species that consistently demonstrates a diminished flow, whereas in the brain, heart, and lungs it may be unchanged or even increased (24). This was demonstrated clearly in our studies by the direct observation of the blanching of the kidney at the height of blood pressure elevation.…”
supporting
confidence: 62%
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“…In rats, infusion of angiotensin reduces renal blood flow and increases vascular resistance; indeed, the kidney is the only organ in this species that consistently demonstrates a diminished flow, whereas in the brain, heart, and lungs it may be unchanged or even increased (24). This was demonstrated clearly in our studies by the direct observation of the blanching of the kidney at the height of blood pressure elevation.…”
supporting
confidence: 62%
“…By 24 hours, when bacteremia had decreased in intensity, a difference was clearly demonstrated. Indeed, the slightly more rapid clearance of bacteria from the blood in the animals with E. coli-angiotensin would favor the concept of renal trapping, as does the demonstration that norepinephrine, which obviously disturbed renal hemodynamics less, had lesser effects on altering renal bacterial levels and susceptibility to infection.…”
mentioning
confidence: 95%
“…The 1-des Asp, 8-Ile AII analogue, conversely, induced a consistent, larger, doserelated renal blood flow increase, with significantly INTRODUCTION Several observations have stuggested that the renal vascular receptor for angiotensin II (All)' differs from systemic vascular angiotensin receptors. First, the renal vasculature is especially sensitive to All (1). Second, the 1-Sar, 8-Ala All analogue (P113) induces a dose-related reduction in renal blood flow which parallels the response to All, but exerts only a limited pressor effect (2,3).…”
mentioning
confidence: 99%
“…The present study reports on the role of the nervous system in determining the renal vascular reactivity to angiotensin II. The renal vascular bed was selected for this study because it is the most sensitive of the regional beds tested to the vasoconstrictor effect of angiotensin II (10). Blockade by autonomic drugs of the renal vasoconstriction produced by angiotensin II was demonstrated.…”
mentioning
confidence: 99%